Pregastar M 75 Capsule

PREGASTAR M 75 CAPSULE by LUPIN LTD.

Pregastar M 75 Capsule is a medication manufactured by Lupin Ltd., primarily prescribed for the management of neuropathic pain.

• Name

  • Brand Name: Pregastar M 75 Capsule
  • Common Name: Not distinctly specified, but it's a combination medicine for neuropathic pain.

• Composition

  • Active Ingredients: Each capsule contains Pregabalin 75 mg and Methylcobalamin 750 mcg.
    • Pregabalin is an anticonvulsant that works by reducing pain signals transmitted by damaged nerves.
    • Methylcobalamin (an active form of Vitamin B12) supports nerve health and aids in the regeneration and protection of damaged nerve cells by producing myelin.

• Uses Pregastar M 75 Capsule is used to manage various types of neuropathic pain in adults. This includes:

  • Painful diabetic neuropathy.
  • Post-herpetic neuralgia (pain after shingles).
  • Neuropathic pain related to spinal cord injury.
  • Fibromyalgia.
  • Peripheral neuropathy (weakness, numbness, and pain from nerve damage, usually in hands and feet).

• Dosage and Administration

  • Pregastar M 75 Capsule should be taken orally as directed by a doctor, with or without food.
  • It is generally recommended to swallow the capsule whole with a glass of water, without crushing or chewing it.
  • To maintain consistent effectiveness, it's advised to take the medicine at the same time each day.
  • Do not stop taking the medicine abruptly, as this can lead to withdrawal symptoms; the dose should be gradually reduced under medical supervision.
  • If a dose is missed, take it as soon as remembered, but skip it if it's almost time for the next scheduled dose. Never double up on doses.

• Side Effects Common side effects may include:

  • Dizziness, drowsiness, and sleepiness.
  • Dry mouth.
  • Weight gain, increased appetite, and oedema (swelling, particularly in hands and feet).
  • Blurred vision or other vision problems.
  • Headache, nausea, vomiting, constipation, or diarrhea.
  • Mood changes, irritability, anxiety, or nervousness.
  • Uncoordinated body movements, tremors, or giddiness.

  Serious side effects, though less common, can include severe allergic reactions (skin rash, itching, swelling of face/lips/throat, difficulty breathing) and muscle pain/weakness. Suicidal thoughts or behavior have also been reported.

• Precautions

  • Pregnancy and Breastfeeding: It is generally not recommended during pregnancy and should be used with caution in breastfeeding women; consult a doctor.
  • Alcohol: Avoid alcohol consumption as it may increase dizziness and sleepiness.
  • Driving and Operating Machinery: Due to potential dizziness, drowsiness, and blurred vision, avoid driving or operating heavy machinery until you know how the medicine affects you.
  • Kidney and Liver Conditions: Use with caution in patients with kidney disease, and dosage adjustment may be required. Caution is also advised for liver issues.
  • Heart Conditions: Caution is advised for patients with heart problems, as it may cause fluid buildup or exacerbate heart failure symptoms.
  • Elderly Patients: Use with caution in elderly patients due to increased risk of dizziness and sleepiness, which can lead to accidental injury.
  • Interactions: Inform your doctor about all other medications, including herbal supplements, as interactions can occur with CNS depressants (e.g., benzodiazepines), ACE inhibitors, and certain other drugs.
  • Allergy: Contraindicated in patients with known hypersensitivity to pregabalin, methylcobalamin, or other components.

• Storage

  • Store Pregastar M 75 Capsule at room temperature, ideally below 30°C (between 15-30°C).
  • Keep it in a tightly sealed container, away from direct light and moisture.
  • Ensure the capsule is out of reach of children and pets.

What is Pregastar M 75 Capsule used for?

Pregastar M 75 Capsule is primarily used to manage neuropathic pain, which is nerve-related pain caused by damage or malfunctioning of the nervous system. This includes conditions such as painful diabetic neuropathy, post-herpetic neuralgia (pain after shingles), spinal cord injury-related neuropathic pain, and fibromyalgia. It also addresses general peripheral neuropathy.

How does Pregastar M 75 Capsule work?

The medicine contains two active ingredients: Pregabalin and Methylcobalamin. Pregabalin works by binding to specific sites on voltage-gated calcium channels in the central nervous system, which reduces the release of pain-signaling neurotransmitters. This action helps to calm overactive nerves. Methylcobalamin, an active form of vitamin B12, supports the health of the nervous system by aiding in the production of myelin, a protective sheath around nerve fibers, thereby promoting nerve regeneration and repair.

What is the usual dosage for Pregastar M 75 Capsule?

The dosage of Pregastar M 75 Capsule should always be taken as directed by your doctor. It is typically taken orally, with or without food, and often at bedtime. It is crucial to maintain a consistent schedule by taking it at the same time each day to ensure stable medication levels in the body. Do not alter your dosage or stop the medication abruptly without consulting your doctor.

What are the possible side effects of Pregastar M 75 Capsule?

Common side effects may include dizziness, drowsiness, dry mouth, oedema (swelling, particularly in hands and feet), weight gain, blurred vision, constipation, nausea, vomiting, headache, and fatigue. More serious but less common side effects can include mood changes and suicidal thoughts. If you experience any severe or persistent side effects, you should consult your doctor immediately.

Is Pregastar M 75 Capsule safe during pregnancy or breastfeeding?

Pregastar M 75 Capsule is generally advised to be avoided during pregnancy as it may pose a risk to the fetus. For women of childbearing age, it is recommended to use effective contraception methods if prescribed this medicine. During breastfeeding, caution is advised as the medicine may pass into breast milk and potentially harm the baby. Your doctor will assess the benefits versus risks before prescribing it.

Can Pregastar M 75 Capsule be taken with other medications?

Pregastar M 75 Capsule can interact with certain medications. For example, it may enhance the effects of CNS depressants like benzodiazepines and alcohol, leading to increased drowsiness or dizziness. When taken with ACE inhibitors (e.g., lisinopril, enalapril), there might be an increased risk of angioedema (a severe allergic reaction causing swelling). It may also interact with lorazepam and antibiotics like chloramphenicol, and its interaction with other medicines is not always clearly understood. Always inform your doctor about all prescription, non-prescription, herbal medicines, and dietary supplements you are currently taking.

What precautions should be taken while using Pregastar M 75 Capsule?

It is important to avoid alcohol while taking this medicine as it can increase dizziness and sleepiness. Due to potential dizziness and drowsiness, you should avoid driving or operating heavy machinery until you know how the medicine affects you. Exercise caution if you have kidney or liver conditions, heart problems (e.g., congestive heart failure, as it might cause fluid buildup), or if you are an elderly patient, as dose adjustments or careful monitoring may be necessary. Do not stop taking the medicine abruptly, as this can lead to withdrawal symptoms such as anxiety, fatigue, sweating, vomiting, depression, and seizures; your doctor will advise on gradual discontinuation. Monitor for any unusual mood changes, depression, or suicidal thoughts and report them to your doctor immediately.

What happens if a dose of Pregastar M 75 Capsule is missed?

If you miss a dose of Pregastar M 75 Capsule, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects.

How should Pregastar M 75 Capsule be stored?

Pregastar M 75 Capsule should be stored at room temperature, ideally between 15-30°C (59-86°F). Keep it in a tightly sealed container, away from direct light and moisture. Always ensure the medicine is kept out of reach of children and pets. Check the expiry date on the package before use.