Tozar H

TOZAR H is a combination medication manufactured by Torrent Pharmaceuticals Ltd. used primarily for managing high blood pressure.

Name

• Common Name: TOZAR H
• Brand Name: TOZAR H Tablet

Composition

TOZAR H Tablet contains two active ingredients:

• Losartan (50 mg)
• Hydrochlorothiazide (12.5 mg)

Losartan is an angiotensin II receptor blocker that relaxes blood vessels, while Hydrochlorothiazide is a diuretic that helps remove excess salt and water from the body.

Uses

TOZAR H Tablet is prescribed for:

• Managing high blood pressure (hypertension), especially when a single medication is not effective.
• Managing fluid build-up (oedema) associated with heart, kidney, or liver diseases.
• Protecting kidneys from damage in individuals with diabetes (diabetic nephropathy).
• Reducing the risk of strokes and heart attacks, particularly in patients with high blood pressure and left ventricular hypertrophy.

Dosage and Administration

• TOZAR H is typically taken once daily, with or without food.
• Swallow the tablet whole; do not chew, crush, or break it.
• It is advisable to take the medicine at a fixed time each day, preferably in the morning to prevent frequent nighttime urination.
• The dosage and duration of treatment should be determined by a healthcare professional. Do not stop taking the medicine suddenly.

Side Effects

• Common Side Effects: Dizziness, headache, fatigue, increased urination, nausea, back pain, diarrhea, stuffy nose, taste changes, upset stomach, decreased blood pressure, increased blood uric acid, increased blood lipid level, glucose intolerance, electrolyte imbalance, and cough.
• Serious Side Effects (seek immediate medical attention): Symptoms of high potassium levels (e.g., problems in heart rhythms, slow heart rate, muscle weakness), allergic reactions (e.g., swelling of the tongue, throat, lips, or face), signs of kidney problems (e.g., swelling in ankles, feet, hands, or sudden weight gain), severe dehydration, rapid or irregular heartbeat, and a severe drop in blood pressure.

Precautions

• Contraindications: Do not use if allergic to Losartan, Hydrochlorothiazide, or sulfonamide medicines. It is contraindicated during pregnancy (especially the second and third trimesters) and breastfeeding. Avoid use in patients with severe liver disorders, anuria, certain electrolyte imbalances (low potassium/sodium, high calcium), gout, or if taking aliskiren with diabetes or kidney problems.
• Warnings: Caution is advised for patients with kidney or liver conditions. Avoid excessive alcohol consumption as it may enhance dizziness and cause orthostatic hypotension. Limit potassium-rich foods and supplements. The medication may cause dizziness; avoid driving or operating heavy machinery if affected. It is not recommended for children under 18 years. Inform your doctor about all existing medical conditions and other medications.

Storage

Store TOZAR H Tablet below 30°C, protected from excessive light and moisture, and out of reach of children.

What is TOZAR H used for?

TOZAR H is a combination medication used primarily to treat high blood pressure (hypertension) when a single medicine (either losartan or hydrochlorothiazide) is not sufficient to control it. It also helps reduce the risk of stroke and heart attack, particularly in patients with left ventricular hypertrophy, and can manage fluid retention (oedema) caused by heart, kidney, or liver diseases. Additionally, it may help protect the kidneys from damage in diabetic patients.

How does TOZAR H work?

TOZAR H contains two active ingredients: Losartan and Hydrochlorothiazide. Losartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of a hormone called angiotensin II, which narrows blood vessels. By blocking this action, Losartan helps relax and widen the blood vessels, leading to lower blood pressure. Hydrochlorothiazide is a diuretic, also known as a "water pill," which increases the production of urine and helps the body eliminate excess water and salt. This combined action reduces fluid volume and relaxes blood vessels, effectively lowering blood pressure.

What is the usual dosage for TOZAR H?

TOZAR H is typically taken once daily, with or without food. It is recommended to swallow the tablet whole with water and try to take it at the same time each day. Your doctor will determine the exact dose and duration based on your condition. To avoid frequent urination at night, it is often suggested to take the medicine in the morning. Do not exceed the prescribed dose or stop taking the medicine suddenly without consulting your doctor.

What are the possible side effects of TOZAR H?

Common side effects of TOZAR H can include dizziness, headache, fatigue, nausea, upset stomach, back pain, and cough. Increased urination is also a normal effect due to the diuretic component. Some individuals might experience dry mouth, extreme thirst, or electrolyte imbalances. More serious but less common side effects that require medical attention include severe dehydration, swelling of the face, lips, or tongue (angioedema), rapid or irregular heartbeat, or a significant drop in blood pressure.

Is TOZAR H safe during pregnancy or breastfeeding?

No, TOZAR H is generally not considered safe during pregnancy. It is contraindicated, especially in the second and third trimesters, as it can cause serious harm or even death to the unborn baby. If you are pregnant or become pregnant while taking this medicine, you should stop immediately and consult your doctor. Similarly, TOZAR H is not recommended during breastfeeding, as its components are known to pass into breast milk, and its effects on the nursing infant are unknown.

Can TOZAR H be taken with other medications?

TOZAR H can interact with several medications. You should avoid taking it with aliskiren if you have diabetes or kidney problems. It is also generally advised to avoid or use caution with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, as they can reduce its effectiveness and potentially impair kidney function. Be cautious with lithium (risk of increased toxicity) and with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium, as these can increase blood potassium levels. Inform your doctor about all other medications, supplements, and herbal products you are taking to prevent potential interactions.

What precautions should be taken while using TOZAR H?

Before starting TOZAR H, inform your doctor about any existing health conditions such as kidney or liver disease, diabetes, gout, or electrolyte imbalances. Avoid excessive alcohol consumption, as it can increase dizziness and further lower blood pressure. Since it can cause dizziness, exercise caution when driving or operating machinery. Regular monitoring of your blood pressure and kidney function is recommended. It is important to stay adequately hydrated but avoid excessive salt intake. The medication is not suitable for children and adolescents under 18 years of age.

How should TOZAR H be stored?

TOZAR H tablets should be stored below 30°C in a closed container. Keep the medication protected from excessive light and moisture, and ensure it is kept out of reach of children.