Olkem Trio 40 Mg Tablet (10 Tab)

OLKEM TRIO 40 MG TABLET

OLKEM TRIO 40 MG TABLET is an antihypertensive medication manufactured by Alkem Laboratories Ltd..

Composition Each tablet contains a combination of three active ingredients:

• Olmesartan Medoxomil: 40 mg
• Cilnidipine: 10 mg
• Chlorthalidone: 12.5 mg

Uses OLKEM TRIO 40 MG TABLET is primarily used for the treatment of essential hypertension (high blood pressure), especially when a single medication is not effective. It works by relaxing blood vessels, improving blood flow, and removing excess water and certain electrolytes from the body, thereby reducing the heart's workload and lowering blood pressure effectively. This action helps to prevent serious cardiovascular complications such as heart attack, stroke, and kidney problems.

Dosage and Administration This medicine should be taken orally as advised by your doctor, typically once daily, preferably with food to avoid stomach upset. Swallow the tablet whole with a glass of water; do not chew, crush, or break it. It is recommended to take it at the same time each day for consistent effects. Due to its diuretic component, avoid taking it within four hours of bedtime to prevent increased urination.

Side Effects Common side effects may include:

• Headache, dizziness, fatigue
• Nausea, diarrhoea, upset stomach
• Peripheral oedema (swelling of legs/hands/ankles)
• Muscle spasms, chills
• Hyperuricemia (elevated uric acid levels), hypokalemia (low potassium levels)
• Taste changes, flushing

More serious but less common side effects can include allergic reactions, severe swelling, or chest pain. Consult your doctor if any side effects persist or worsen.

Precautions OLKEM TRIO 40 MG TABLET is contraindicated in pregnant women due to potential risks to the developing baby. It is also not recommended for breastfeeding women. Avoid use if you have severe kidney disease (including anuria) or liver disease, low blood pressure (hypotension), cardiogenic shock, aortic stenosis, or are allergic to any of its components. Caution is advised for patients with heart failure, low sodium or high calcium/uric acid levels, or those on a low-salt diet. Alcohol consumption, grapefruit juice, and St. John's wort should be avoided as they may interact with the medicine. Regular monitoring of blood pressure, kidney function, electrolytes, and blood sugar levels is recommended during treatment. This medication may cause dizziness, so avoid driving or operating heavy machinery if affected.

Storage Store OLKEM TRIO 40 MG TABLET in a cool, dry place, ideally between 15°C and 25°C, away from direct sunlight and heat. Keep it out of the reach and sight of children. Avoid storing in damp areas like bathrooms or near kitchen sinks.

What is Olkem Trio 40 mg Tablet used for?

Olkem Trio 40 mg Tablet is primarily used to treat hypertension (high blood pressure), especially when a single medication is not sufficient to control it. By effectively lowering blood pressure, it helps reduce the risk of serious complications such as heart attack, stroke, and kidney problems.

How does Olkem Trio 40 mg Tablet work?

Olkem Trio 40 mg Tablet is a combination of three active ingredients: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone.

• Olmesartan medoxomil is an angiotensin receptor blocker (ARB) that works by blocking the hormone angiotensin, which relaxes blood vessels and allows blood to flow more smoothly.
• Cilnidipine is a calcium channel blocker (CCB) that blocks calcium channels in the blood vessels, which helps relax the vessels and reduces the heart's workload, allowing it to pump blood more efficiently.
• Chlorthalidone is a diuretic (water pill) that helps the body eliminate excess water and certain electrolytes (like salt) through urine, thereby reducing blood volume and lowering blood pressure.

What is the usual dosage for Olkem Trio 40 mg Tablet?

You should take Olkem Trio 40 mg Tablet exactly as prescribed by your doctor. It is typically taken once a day. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or broken. While it can be taken with or without food, some sources suggest taking it with food to avoid stomach upset and for slower absorption. It is beneficial to take it at the same time each day for consistent results. Since it contains a diuretic, it's generally best to avoid taking it within four hours of bedtime to prevent increased urination during the night.

What are the possible side effects of Olkem Trio 40 mg Tablet?

Common side effects may include headache, dizziness, nausea, swelling of the legs or hands (peripheral edema), fatigue, increased urination, and changes in taste. Other less common side effects can include dry mouth, muscle spasms, increased uric acid levels in the blood (hyperuricemia), low potassium levels (hypokalemia), and low magnesium levels (hypomagnesemia). If you experience severe side effects such as allergic reactions, significant swelling, or chest pain, seek immediate medical attention. The medication may also cause a sudden drop in blood pressure when standing (orthostatic hypotension).

Is Olkem Trio 40 mg Tablet safe during pregnancy or breastfeeding?

Pregnancy: Olkem Trio 40 mg Tablet is considered unsafe and is not recommended during pregnancy or if you are planning to become pregnant, as there is definitive evidence of risk to the developing baby. If you become pregnant while taking this medicine, discontinue use and consult your doctor immediately. Breastfeeding: This medicine is generally not recommended during breastfeeding. Components of the medicine can pass into breast milk, and its effect on the infant is not fully known. It is important to consult your doctor for advice if you are breastfeeding.

Can Olkem Trio 40 mg Tablet be taken with other medications?

It is crucial to inform your doctor about all other medications, herbal preparations, and supplements you are currently taking or plan to take. Certain medications and substances should be used with caution or avoided:

• Aliskiren: Co-administration with aliskiren is not recommended, especially in patients with diabetes or kidney problems.
• Potassium Supplements & Potassium-Sparing Diuretics: These can increase potassium levels in the blood.
• NSAIDs (Non-Steroidal Anti-inflammatory Drugs): Such as ibuprofen or aceclofenac, may interact with Olkem Trio 40 mg Tablet.
• Other Blood Pressure Medications: Taking it with other antihypertensive medicines (e.g., ramipril, lisinopril, valsartan, captopril) can lead to a significant drop in blood pressure.
• Lithium: Concomitant use with lithium is not recommended.
• Grapefruit juice and St. John's wort: These are contraindicated and should not be consumed while taking this medicine.
• Alcohol: Avoid alcohol consumption as it can further lower blood pressure and increase the risk of side effects like dizziness.

What precautions should be taken while on Olkem Trio 40 mg Tablet?

• Do not stop taking this medicine abruptly without consulting your doctor, as it can cause a sudden increase in blood pressure and raise the risk of heart attack or stroke.
• This medicine may cause dizziness or drowsiness, so avoid driving or operating heavy machinery until you know how it affects you.
• Use with caution if you have pre-existing conditions such as low blood pressure, heart disorders (like heart failure or a history of heart attack), kidney disease (especially severe impairment or anuria), liver disease, diabetes, gout, or electrolyte imbalances.
• Your doctor will likely monitor your blood pressure, kidney function, electrolyte levels (potassium, sodium, magnesium), and blood sugar regularly during treatment.
• Ensure adequate fluid intake to help manage potential side effects like muscle weakness or dry mouth.
• Olkem Trio 40 mg Tablet is not recommended for use in children.
• Elderly patients (65 years and above) should use this medicine with caution, and dose adjustments may be necessary with regular monitoring.

What happens if a dose of Olkem Trio 40 mg Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Olkem Trio 40 mg Tablet be stored?

Store Olkem Trio 40 mg Tablet in a cool, dry place, typically at room temperature between 15°C and 25°C. Keep it away from direct light and moisture. Avoid storing it in damp areas like bathrooms or near a kitchen sink. Always keep this medicine out of the reach and sight of children.