Ethide 250 Mg (12 Tab)

ETHIDE 250 MG (12 TAB) by LUPIN LTD

Ethide 250 MG Tablet is an antibiotic medication manufactured by Lupin Ltd, primarily used in the treatment of tuberculosis (TB).

• Name:
  • Brand Name: Ethide 250 MG Tablet
  • Common Name: Ethionamide
• Composition:
  • Each tablet contains Ethionamide 250 mg.
• Uses:
  • Ethide 250 MG Tablet is prescribed for the management of tuberculosis infection, mainly affecting the lungs and sometimes other body parts.
  • It is typically used as a second-line treatment in active TB infections, especially when the bacteria show resistance to other first-line anti-TB medications. It is always administered in combination with at least one other anti-tuberculosis drug to prevent rapid development of resistance.
• Dosage and Administration:
  • Take Ethide tablets exactly as prescribed by your doctor.
  • Do not exceed the recommended dosage and do not break or chew the tablet.
  • It can be taken with or without food, preferably at the same time each day. However, taking it with food may help avoid stomach upset.
  • Complete the entire course of treatment, even if symptoms improve, to prevent the infection from returning or developing drug resistance.
  • If a dose is missed, take it as soon as remembered, but skip it if the next dose is almost due. Do not double the dose.
• Side Effects:
  • Common: Loss of appetite, nausea, vomiting, gastric irritation, abdominal pain, diarrhea, increased salivation, metallic taste, mouth sores, weakness, depression, sleepiness, and orthostatic hypotension (sudden drop in blood pressure on standing).
  • Serious: Immediately consult a doctor if you experience signs of liver toxicity such as confusion, seizures, dark urine, clay-colored stools, jaundice (yellowing of skin or eyes), or pain in the upper right abdomen.
• Precautions:
  • Pregnancy and Breastfeeding: Not recommended during pregnancy as it may cause fetal harm; consult your doctor. Avoid breastfeeding as the medicine can pass into breast milk.
  • Liver/Kidney Disease: Contraindicated in severe liver dysfunction. Use with caution in liver disease, and dose adjustments may be needed for kidney impairment.
  • Alcohol: Avoid alcohol consumption as it may increase the risk of psychotic disorders or liver problems.
  • Diabetes: Ethide can lower blood sugar levels; diabetic patients should monitor their blood glucose frequently.
  • Driving: May cause drowsiness, dizziness, numbness, tingling sensation, or blurred vision; avoid driving or operating heavy machinery if these occur.
  • Interactions: Avoid foods high in tyramine. It can increase the side effects of other TB medicines, like isoniazid, potentially leading to peripheral neuropathy and liver toxicity.
  • Monitoring: Regular monitoring of liver function, vision, and thyroid function is often advised during treatment.
  • Pediatric Use: Generally not recommended for children under 12 years of age without specific medical advice.
• Storage:
  • Store Ethide tablets in dry conditions at room temperature, away from moisture and direct sunlight.
  • Keep out of the sight and reach of children and pets.

Here are some frequently asked questions about ETHIDE 250 MG (Ethionamide):

What is ETHIDE 250 MG used for?

ETHIDE 250 MG, which contains the active ingredient Ethionamide, is an antibiotic primarily used to treat tuberculosis (TB). It is particularly used in cases where the bacteria have developed resistance to other first-line anti-tuberculosis medications, or when patients cannot tolerate other drugs. It is always used in combination with at least one, and often several, other anti-tuberculosis medicines. It is not effective against viral infections like colds or the flu.

How does ETHIDE 250 MG work?

Ethionamide is a prodrug that is activated by an enzyme (EthA) in Mycobacterium tuberculosis, the bacteria causing TB. Once activated, it works by interfering with the synthesis of mycolic acid, a crucial component of the bacterial cell wall. This disruption compromises the structural integrity of the bacteria, inhibiting their growth and leading to their death.

What is the usual dosage for ETHIDE 250 MG?

The dosage of ETHIDE 250 MG is determined by your doctor based on body weight and the specific condition being treated. For adults, the typical daily dose ranges from 500 mg to 1 gram (1000 mg), usually not exceeding 1000 mg per day. It often starts with 250 mg once daily and may be gradually increased. This daily dose can be taken as a single dose or divided into two to three doses to improve tolerability. For children 12 years and older, the dose is usually 10 to 20 mg per kilogram of body weight per day. It is important to follow your doctor's instructions precisely.

What are the possible side effects of ETHIDE 250 MG?

Common side effects can include gastrointestinal issues such as nausea, vomiting, diarrhea, stomach pain, loss of appetite, increased salivation, and a metallic taste in the mouth. More serious, though less common, side effects that should be reported to your doctor immediately include liver inflammation (symptoms like yellowing of skin/eyes, dark urine, unusual fatigue), changes in vision (blurred vision, loss of vision, eye pain), peripheral neuropathy (numbness, tingling, burning pain in hands or feet), depression or other psychiatric disturbances, and severe skin reactions (rash, blistering, peeling skin). Ethionamide can also affect thyroid function, potentially leading to low thyroid levels.

Is ETHIDE 250 MG safe during pregnancy or breastfeeding?

ETHIDE 250 MG is generally not recommended for use during pregnancy unless specifically deemed necessary by a doctor, as there are no adequate and well-controlled studies to determine infant risk. It is also advised to avoid breastfeeding while taking Ethionamide, as the medication may pass into breast milk. Discuss the potential benefits and risks with your healthcare provider.

Can ETHIDE 250 MG be taken with other medications?

Yes, ETHIDE 250 MG must always be taken in combination with other anti-tuberculosis medications, as using it alone can quickly lead to drug resistance. However, it can interact with various other drugs, potentially increasing side effects. Notable interactions include those with other antitubercular drugs like cycloserine and isoniazid, certain local anesthetics, and medications for thyroid disorders or diabetes. Alcohol consumption should be avoided while taking Ethionamide due to an increased risk of liver problems or mental/mood changes. Always inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should be taken while on ETHIDE 250 MG?

Regular medical check-ups are crucial to monitor your progress and check for unwanted effects. Your doctor may order frequent blood tests to assess liver and thyroid function, as well as regular vision tests. If you have diabetes, monitor your blood sugar levels carefully, as Ethionamide can lower them. Avoid alcohol. It is very important to complete the full course of treatment as prescribed, even if you start to feel better, to prevent the infection from returning or developing drug resistance. Sometimes, doctors may also prescribe pyridoxine (Vitamin B6) to help prevent or lessen certain neurotoxic side effects. Use of Ethionamide is not recommended in children younger than 12 years of age.

What happens if a dose of ETHIDE 250 MG is missed?

If you miss a dose of ETHIDE 250 MG, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects. Consistently missing doses can lead to the infection becoming resistant to the medication.

How should ETHIDE 250 MG be stored?

ETHIDE 250 MG should be stored in a closed container at room temperature, away from excessive heat, moisture, and direct light. It should be kept from freezing and out of the reach of children.