Ryaltris Az Nasal Spray 75 Metered Doses (9.5 Gm)

RYALTRIS AZ NASAL SPRAY 75 METERED DOSES (9.5 GM) by GLENMARK PHARMACEUTICALS LTD.

Ryaltris-AZ Nasal Spray is a combination medication designed to provide comprehensive relief from symptoms associated with allergic rhinitis. It targets both immediate allergic reactions and underlying inflammation in the nasal passages.

Name

• Brand Name: RYALTRIS AZ NASAL SPRAY
• Common Names: Azelastine Hydrochloride and Mometasone Furoate Nasal Spray

Composition

Each metered spray of RYALTRIS AZ contains:

• Azelastine Hydrochloride: 140 mcg (an antihistamine)
• Mometasone Furoate: 50 mcg (a corticosteroid)

Uses

Ryaltris-AZ Nasal Spray is primarily used to treat symptoms of allergic rhinitis, which include:

• Sneezing
• Itching (in the nose and eyes)
• Runny nose
• Stuffy/Blocked nose and nasal congestion

It is effective for both seasonal and perennial allergic rhinitis.

Dosage and Administration

• Typical Dosage: The recommended dosage is typically two sprays in each nostril twice daily (e.g., morning and evening).
• Administration:
  • Shake the bottle well before each use.
  • Before initial use, prime the pump by releasing 6 sprays into the air until a fine mist appears.
  • If the spray has not been used for 14 or more days, re-prime with 2 sprays or until a fine mist appears.
  • Gently blow your nose to clear your nostrils.
  • Close one nostril and insert the spray tip into the other, directing it towards the side of the nostril, away from the nasal septum.
  • Breathe in gently as you spray. Repeat for the other nostril.
  • Avoid spraying into the eyes or mouth.
  • Do not blow your nose for at least 15 minutes after use to ensure the medicine is absorbed.
• Pediatric Use: Safety and effectiveness have been established for pediatric patients 12 years of age and older. It should be used in children only when prescribed by a doctor.

Side Effects

Common side effects may include:

• Headache
• Nosebleeds (epistaxis)
• Nasal discomfort or irritation
• Changes in taste or unpleasant taste
• Sneezing
• Pharyngitis (sore throat)
• Dry mouth or throat pain
• Drowsiness or tiredness

Serious side effects are rare but may include hypersensitivity reactions (wheezing, hives, difficulty breathing, swelling of face/lips/tongue/throat), severe dizziness, or serious eye symptoms like sudden vision loss. Consult a doctor if any side effects persist or worsen.

Precautions

• Hypersensitivity: Contraindicated in patients with known hypersensitivity to any ingredients.
• Nasal Conditions: Do not use if you have an untreated nasal infection, have recently had nose surgery, or experienced a nose injury, as it may worsen the condition or impair healing.
• Drowsiness: This medicine can cause drowsiness. Exercise caution when driving or operating machinery and avoid alcohol, which can enhance these effects.
• Growth in Children: Growth of pediatric patients receiving nasal corticosteroids should be monitored routinely.
• Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.
• Underlying Medical Conditions: Inform your doctor if you have heart, liver, or kidney diseases, tuberculosis, or immune system disorders.
• Concurrent Medications: Inform your doctor about all other medicines, including corticosteroids, to avoid potential interactions.

Storage

• Store upright with the dust cap on, at room temperature, between 20°C to 25°C (68°F to 77°F).
• Do not freeze or refrigerate.
• Keep out of sight and reach of children and pets.
• Discard the bottle after the specified number of sprays (e.g., 240 metered sprays after initial priming) or two months after first opening, even if it feels like there is medicine remaining, to ensure correct dosing.

RYALTRIS AZ Nasal Spray is a prescription medication used to alleviate symptoms associated with allergic rhinitis. Here are some frequently asked questions about this medicine:

What is RYALTRIS AZ Nasal Spray used for?

RYALTRIS AZ Nasal Spray is primarily used to relieve symptoms of allergic rhinitis, including blocked or runny nose, sneezing, and itchy or watery eyes. It helps manage symptoms caused by allergens such as pollen, dust mites, mold, or pet dander.

How does RYALTRIS AZ Nasal Spray work?

This nasal spray is a combination of two active ingredients: mometasone furoate and azelastine (or olopatadine, depending on the specific product formulation). Mometasone is a corticosteroid that reduces swelling and inflammation in the nasal passages. Azelastine (an antihistamine) or olopatadine (a histamine H1-receptor inhibitor) works by blocking the effects of histamine, a natural chemical in the body that causes allergy symptoms like sneezing, runny nose, and itching.

What is the usual dosage for RYALTRIS AZ Nasal Spray?

For adults and adolescents 12 years of age and older, the recommended dosage is two sprays into each nostril twice daily (morning and evening). For children aged 6 to 11 years, the recommended dose is one spray per nostril twice daily (morning and evening). It is important to shake the bottle well before each use and prime the pump before initial use or if it hasn't been used for 14 or more days.

What are the possible side effects of RYALTRIS AZ Nasal Spray?

Common side effects may include headache, unpleasant taste in the mouth (dysgeusia), nosebleeds (epistaxis), nasal discomfort or irritation, sneezing, sore throat, and dry nose. Less common but more serious side effects can include sores in the nose, a hole in the cartilage between the nostrils (nasal septal perforation), fungal infections in the nose or throat (thrush), eye problems like glaucoma or cataracts, drowsiness, and slowed growth in children. If you experience severe eye symptoms or any signs of a serious allergic reaction, seek medical attention immediately.

Is RYALTRIS AZ Nasal Spray safe during pregnancy or breastfeeding?

If you are pregnant or planning to become pregnant, or if you are breastfeeding, it is important to consult your doctor before using RYALTRIS AZ Nasal Spray. Limited human studies are available for Ryaltris specifically during pregnancy. While some components like mometasone have been used in pregnancy with no clear evidence of harm, other components may have less data. It is unknown if the medications pass into breast milk. Your doctor will weigh the potential benefits against any potential risks to the baby. Breastfeeding is often not recommended while using this medicine.

Can RYALTRIS AZ Nasal Spray be taken with other medications?

It is crucial to inform your doctor about all prescription and over-the-counter medications, vitamins, and herbal supplements you are currently taking. RYALTRIS AZ Nasal Spray can cause drowsiness, and this effect may be increased if taken with alcohol or other central nervous system (CNS) depressants. Certain medications, particularly strong CYP3A4 inhibitors such as ketoconazole, clarithromycin, or ritonavir, can increase the blood levels of Ryaltris, potentially raising the risk of side effects.

What precautions should be taken when using RYALTRIS AZ Nasal Spray?

Before using this spray, inform your doctor if you have any existing medical conditions, especially a history of tuberculosis or other untreated infections (fungal, bacterial, viral, or ocular herpes simplex). You should also inform your doctor if you have recently had nasal surgery, injury, or sores in your nose, as the spray should not be used until your nose has healed. Regular eye exams are recommended if you have a history of increased intraocular pressure, glaucoma, or cataracts, as this medication may affect them. Due to the potential for drowsiness, avoid driving or operating machinery until you know how the spray affects you.

What happens if a dose of RYALTRIS AZ Nasal Spray is missed?

If you miss a dose of RYALTRIS AZ Nasal Spray, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use extra sprays to make up for a missed dose.

How should RYALTRIS AZ Nasal Spray be stored?

RYALTRIS AZ Nasal Spray should be stored upright with the dust cap on, at room temperature, ideally between 68°F to 77°F (20°C to 25°C). Do not freeze or refrigerate the bottle. Keep it in a cool, dry place, away from direct sunlight, and out of reach of children and pets. Discard the bottle after the specified number of sprays (e.g., 240 metered sprays) even if it appears to still contain medicine, as you may not receive the correct dose.