Dobesil 500 Mg Capsule (10 Cap)

DOBESIL 500 MG CAPSULE

DOBESIL 500 MG CAPSULE, manufactured by SUN PHARMACEUTICAL IND.LTD., is a medication primarily used for its vasoprotective properties, addressing various circulatory disorders.

• Name:

  • Brand Name: Dobesil 500 mg Capsule
  • Common Name: Calcium Dobesilate (also known by other brand names like Dobuheal, Doxium, etc.)

• Composition:

  • Each capsule contains Calcium Dobesilate Monohydrate BP 500 mg as the active ingredient.

• Uses: DOBESIL 500 MG CAPSULE is indicated for the treatment and management of several conditions affecting blood vessels and circulation:

  • Hemorrhoids (Piles): Helps alleviate pain, swelling, irritation, and itching by strengthening blood vessels and reducing inflammation.
  • Varicose Veins: Improves venous tone, reduces swelling, discomfort, and inflammation in enlarged, swollen, and twisted veins, particularly in the legs.
  • Diabetic Retinopathy: Protects retinal capillaries, slows the progression of microvascular damage, and improves blood flow in the eye.
  • Chronic Venous Insufficiency: Addresses clinical signs such as heaviness in legs, leg cramps, ankle edema, and dermatosis.
  • Microcirculation Disorders: Improves blood flow by decreasing blood viscosity and capillary hyperpermeability.
  • Also indicated for diabetic foot ulcers and as an adjuvant therapy in superficial thrombophlebitis.

• Dosage and Administration:

  • Typically, one to two 500 mg capsules are taken daily with the main meals.
  • Dosage should be individualized based on the severity of the case and duration of treatment can range from a few weeks to several months.
  • The capsule should be swallowed whole with water; do not chew, crush, or break it.
  • Follow your doctor's instructions regarding dosage and duration.

• Side Effects: Common side effects may include:

  • Skin rash
  • Fever
  • Nausea and vomiting
  • Gastrointestinal disorders (e.g., diarrhea, epigastric pain, gastric irritation)
  • Joint pain (arthralgia)
  • Pruritus (itching) A rare but serious side effect reported is agranulocytosis (a reduction in white blood cell count), which may manifest with symptoms like high fever, oral cavity infections, or sore throat.

• Precautions:

  • Hypersensitivity: Contraindicated in patients with known hypersensitivity to calcium dobesilate.
  • Renal Impairment: Dosage should be reduced in individuals with severe renal insufficiency, especially those requiring dialysis.
  • Liver Impairment: Use with caution in patients with liver impairment.
  • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding, as safety has not been definitively established and benefits must outweigh potential risks.
  • Children: Not recommended for children as safety and efficacy have not been established.
  • Driving and Machinery: May cause drowsiness; caution is advised when driving or operating heavy machinery.
  • Alcohol: Avoid consuming alcohol as it may increase drowsiness.
  • Other Conditions: Patients with respiratory disease, heart disease, epilepsy, low blood pressure, duodenal/peptic ulcer, or recurrent gastritis should use with caution and under medical supervision.

• Storage:

  • Store in a cool and dry place.
  • Keep below 30°C.
  • Protect from light and moisture.
  • Keep out of the reach and sight of children.

DOBESIL 500 MG CAPSULE, containing Calcium Dobesilate, is a medication primarily used to improve blood circulation and strengthen blood vessels. Here are some frequently asked questions about this medicine:

What is Dobesil 500 mg Capsule used for?

Dobesil 500 mg Capsule is primarily used for the treatment of haemorrhoids (piles), varicose veins, chronic venous insufficiency, and diabetic retinopathy. It can also alleviate symptoms such as heaviness in legs, leg cramps, and ankle edema. For piles, it helps reduce inflammation, bleeding, pain, swelling, irritation, and itching by strengthening blood vessels. In varicose veins, it improves venous tone, reduces swelling and discomfort, and prevents blood clotting. For diabetic retinopathy, it protects retinal capillaries and slows the progression of microvascular damage.

How does Dobesil 500 mg Capsule work?

Dobesil 500 mg Capsule contains Calcium Dobesilate, which acts on the walls of small blood vessels (capillaries) to improve their integrity and function. It works by decreasing the thickness of blood, reducing the leakage and fragility of blood vessels, and improving blood flow. It also helps by decreasing capillary hyperpermeability, inhibiting platelet aggregation, and enhancing red blood cell flexibility, thereby improving microcirculation. The medicine also exhibits antioxidant properties, contributing to healing.

What is the usual dosage for Dobesil 500 mg Capsule?

The typical dosage is usually one capsule (500 mg) once or twice daily, taken after meals. The duration of treatment, which can range from a few weeks to several months, depends on the specific condition and its evolution. Your doctor will determine the appropriate dosage and treatment duration based on your individual needs and the severity of your condition.

What are the possible side effects of Dobesil 500 mg Capsule?

Common side effects may include gastrointestinal disorders such as nausea, vomiting, diarrhea, epigastric pain, and gastric irritation. Skin reactions, including rash and pruritus (itching), and joint pain (arthralgia) can also occur. Rarely, more severe side effects like agranulocytosis (a decrease in white blood cells) have been reported, which may present with symptoms like high fever or oral infections. Drowsiness and vision disturbances are also possible. Most of these side effects are usually temporary and resolve over time.

Is Dobesil 500 mg Capsule safe during pregnancy or breastfeeding?

Dobesil 500 mg Capsule is classified as Pregnancy Category C, meaning safety during pregnancy has not been well-established. It is not known if Calcium Dobesilate crosses the placental barrier in humans. Therefore, it should only be administered during pregnancy if the potential benefits outweigh the possible risks to the fetus, and always under the guidance of a doctor. For breastfeeding mothers, caution is advised as safety has not been established, and it is recommended to consult a doctor, who may suggest either stopping the treatment or breastfeeding.

Can Dobesil 500 mg Capsule be taken with other medications?

There is limited information available regarding specific drug-drug interactions for Dobesil 500 mg Capsule. Some sources indicate no known drug-drug interactions. However, it is advisable to inform your doctor about all other medications you are taking, including over-the-counter drugs, supplements, and herbal products, to avoid potential interactions. It may interact with blood thinners (e.g., warfarin, heparin), nonsteroidal anti-inflammatory drugs (NSAIDs like ibuprofen), anticoagulants (e.g., aspirin), and antiplatelet drugs (e.g., clopidogrel). Caution is also advised if taking medications for diabetes, such as metformin, as it could affect blood glucose levels.

What precautions should be taken while using Dobesil 500 mg Capsule?

Several precautions should be observed:

• Allergies: Do not take Dobesil 500 mg Capsule if you have a known hypersensitivity or allergy to Calcium Dobesilate or any of its components.
• Kidney/Liver Conditions: Dosage should be reduced in cases of severe renal insufficiency (kidney disease), especially if requiring dialysis. Use with caution in patients with liver impairment/disease.
• Drowsiness: The medicine may cause drowsiness or vision disturbances; therefore, avoid driving or operating heavy machinery if you experience these effects.
• Alcohol: Avoid consuming alcohol, as it may increase drowsiness.
• Children: The safety and efficacy of Dobesil 500 mg Capsule have not been established in children, so it should not be given to them.
• Other Conditions: Inform your doctor if you have other health conditions such as respiratory disease, heart disease, epilepsy, low blood pressure, duodenal or peptic ulcers, recurrent gastritis, or bleeding disorders.
• Agranulocytosis: In rare cases, agranulocytosis can occur. If you develop symptoms like high fever, sore throat, or oral infections, contact your doctor immediately.
• Do not stop abruptly: Do not abruptly stop taking Dobesil 500 mg Capsule as it might lead to withdrawal symptoms like headache, vision problems, fever, or muscle pain.

What happens if a dose of Dobesil 500 mg Capsule is missed?

If you miss a dose of Dobesil 500 mg Capsule, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Dobesil 500 mg Capsule be stored?

Dobesil 500 mg Capsule should be stored in a cool and dry place, away from direct sunlight, light, and moisture. It should be kept out of the sight and reach of children. The storage temperature typically recommended is below 30°C or between 10ºC to 25ºC.