Jardiance Met 12.5 Mg /1000 Mg Tablet (10 Tab)

JARDIANCE MET 12.5 MG /1000 MG TABLET

JARDIANCE MET 12.5 MG /1000 MG TABLET is a prescription medication manufactured by BOEHRINGER INGELHEIM INDIA PVT. LTD. It is a combination therapy for the management of Type 2 Diabetes Mellitus.

• Name

  • Brand Name: JARDIANCE MET (also referred to as Jardiance Duo)
  • Generic Name: Empagliflozin and Metformin Hydrochloride

• Composition

  • Each film-coated tablet contains Empagliflozin 12.5 mg and Metformin Hydrochloride 1000 mg.

• Uses JARDIANCE MET is primarily used as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes Mellitus. It is prescribed when treatment with both empagliflozin and metformin is considered appropriate, particularly when blood sugar levels are not adequately controlled with metformin alone or in combination with other antidiabetic agents. Additionally, it is used to:

  • Reduce the risk of cardiovascular death, heart attack, stroke, and hospitalization for heart failure in adults with Type 2 Diabetes and established cardiovascular disease.
  • Lower the risk of worsening kidney disease, end-stage kidney disease, and hospitalization for heart failure in patients with chronic kidney disease.
  • It may also be used in children aged 10 years and above with Type 2 Diabetes Mellitus under appropriate medical guidance.

• Dosage and Administration

  • JARDIANCE MET should be taken orally with meals to minimize gastrointestinal upset.
  • The typical dosage is usually one tablet once or twice daily, as prescribed by your doctor.
  • Swallow the tablet whole; do not crush, chew, or break it.
  • It is recommended to take the medicine at the same time each day to maintain consistent blood sugar control.
  • Dosage is individualized based on the patient's current regimen, effectiveness, and tolerability.
  • Do not discontinue the medicine without consulting your doctor, as this can lead to an increase in blood sugar levels and potential complications.

• Side Effects

  • Common Side Effects: Frequent urination, mild skin rash or itchy skin, nausea, vomiting, diarrhea, stomach ache, loss of appetite, urinary tract infection, female/male genital mycotic infections (yeast infections), upper respiratory tract infection, dyslipidemia (abnormal lipid levels in blood), joint pain, taste changes, headache, weakness, runny or stuffy nose, and sore throat.
  • Serious Side Effects (Seek immediate medical attention if experienced): Signs of dehydration (dizziness, confusion, feeling very thirsty, decreased urination), ketoacidosis (nausea, vomiting, stomach pain, confusion, unusual drowsiness, trouble breathing), lactic acidosis (unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, feeling very weak or tired), severe genital infections (Fournier's gangrene, characterized by burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, and general unwellness), or severe hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines or alcohol.

• Precautions

  • JARDIANCE MET is not for treating Type 1 Diabetes Mellitus.
  • It is contraindicated in patients with severe kidney or liver disease, metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis), diabetic pre-coma, or conditions that may affect kidneys such as severe infection or dehydration.
  • Avoid alcohol consumption as it may increase the risk of lactic acidosis.
  • Pregnant or breastfeeding women should consult their doctor before taking this medicine, as it is generally not recommended during these periods.
  • Inform your doctor about all other medications, supplements, or herbal products you are taking, and your complete medical history, to prevent potential drug interactions or adverse effects.
  • Regular monitoring of blood sugar levels is important during treatment.
  • Be aware of signs of dehydration and ensure adequate fluid intake, especially during illness (e.g., vomiting or diarrhea).

• Storage

  • Store JARDIANCE MET in a cool and dry place, away from direct sunlight.
  • Keep the tablets stored below 30°C.

JARDIANCE MET 12.5 MG /1000 MG TABLET (10 TAB) FAQs

What is JARDIANCE MET used for?

JARDIANCE MET 12.5 mg/1000 mg Tablet is used to manage type 2 diabetes mellitus in adults. It is prescribed along with diet and exercise to improve blood sugar control, particularly in individuals whose diabetes isn't adequately controlled by metformin alone or metformin combined with other diabetes medicines. This medication can also reduce the risk of cardiovascular death, heart attack, heart failure, and other cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. It also helps in reducing the risk of kidney damage, blindness, nerve problems, and loss of limbs, and can slow the progression of kidney disease.

How does JARDIANCE MET work?

JARDIANCE MET contains two active ingredients: empagliflozin and metformin. Empagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitor. It works by blocking the SGLT2 protein in the kidneys, which prevents the reabsorption of glucose back into the bloodstream and instead causes excess glucose to be excreted through the urine. Metformin is a biguanide that reduces the production of glucose in the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin. Together, these mechanisms more effectively lower blood glucose levels.

What is the usual dosage of JARDIANCE MET?

The dosage of JARDIANCE MET is individualized by your doctor based on your current regimen, effectiveness, and tolerability. It is typically taken once or twice daily with meals to help reduce stomach upset. It's important to take this medicine at the same time each day for optimal benefits. The maximum recommended daily dose is 25 mg of empagliflozin and 2000 mg of metformin.

What are the possible side effects?

Common side effects of JARDIANCE MET can include urinary tract infections (UTIs), genital fungal (yeast) infections, increased urination frequency, nausea, vomiting, diarrhea, abdominal pain, joint pain, and loss of appetite. Drinking plenty of fluids can help prevent dehydration. More serious but rare side effects include ketoacidosis (a buildup of acid in the body), severe UTIs (including kidney infections), dehydration, and low blood sugar (especially when taken with other diabetes medicines like insulin or sulfonylureas).

Is it safe during pregnancy or breastfeeding?

JARDIANCE MET is generally not recommended during the second and third trimesters of pregnancy due to animal studies showing potential for kidney damage in fetuses. If you are pregnant or might become pregnant, discuss suitable treatment options with your doctor, as uncontrolled diabetes during pregnancy can pose significant risks to both mother and fetus. Taking JARDIANCE MET while breastfeeding is also not recommended, as empagliflozin may pass into breast milk, and its effect on a breastfed infant is unknown but could potentially affect kidney development.

Can it be taken with other medications?

JARDIANCE MET can interact with other medications. Taking it with other antidiabetic medicines, especially insulin or insulin secretagogues (like sulfonylureas and glinides), can increase the risk of low blood sugar (hypoglycemia). Diuretics ("water pills") taken with JARDIANCE MET may increase the risk of dehydration and low blood pressure due to increased urination. It's crucial to inform your doctor about all medications, supplements, and herbal products you are taking to manage potential interactions.

What precautions should be taken?

Avoid excessive alcohol consumption while taking JARDIANCE MET, as it can increase the risk of lactic acidosis (a serious medical condition) and may also cause fluctuations in blood sugar levels. Patients with kidney or liver problems should use this medication with caution, and it may not be recommended for those with severe kidney impairment. Monitor your blood sugar levels regularly as advised by your doctor. Also, be aware of signs of dehydration and maintain good hygiene to prevent genital fungal infections. Inform your doctor if you have a history of urinary tract infections, as JARDIANCE MET can increase this risk.

What happens if a dose is missed?

If you miss a dose of JARDIANCE MET, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects.

How should it be stored?

JARDIANCE MET tablets should be stored in a cool, dry place, away from direct sunlight, and out of the reach of children and pets. The temperature should ideally remain below 30°C.