Dapanorm Trio Tablet

DAPANORM TRIO TABLET by ALKEM LABORATORIES LTD

Dapanorm Trio Tablet is a combination medication prescribed for the comprehensive management of Type 2 Diabetes Mellitus in adults, used as an adjunct to diet and exercise.

• Composition: Each tablet typically contains Dapagliflozin (10mg), Sitagliptin (100mg), and Metformin (500mg).

  • Dapagliflozin: A Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitor that removes excess glucose from the body via urine.
  • Sitagliptin: A Dipeptidyl Peptidase-4 (DPP-4) inhibitor that increases insulin release and decreases glucagon levels when blood sugar is high.
  • Metformin: A biguanide that reduces glucose production by the liver and delays sugar absorption from the intestines, also improving insulin sensitivity.

• Uses: It is used to improve blood sugar control, reduce HbA1c levels, and may offer benefits in weight management and cardiovascular and kidney protection in some patients.

• Dosage and Administration: Dapanorm Trio Tablet should be taken orally as advised by your doctor, usually once or twice daily. It is generally recommended to take it with meals to minimize gastrointestinal upset. The tablet should be swallowed whole with water; do not crush, chew, or break it.

• Side Effects:

  • Common: Nausea, vomiting, abdominal pain, headache, diarrhea, stomach upset, urinary tract infections, and genital fungal infections.
  • Serious (Rare): Lactic acidosis (due to Metformin accumulation), acute pancreatitis, severe allergic reactions, or bullous pemphigoid.

• Precautions: Do not use if allergic to any components or in cases of severe liver or kidney disease, Type 1 diabetes, or diabetic ketoacidosis. Caution is advised for pregnant or breastfeeding women; consult your doctor. Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis and hypoglycemia. Regular monitoring of blood sugar levels is essential.

• Storage: Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of the sight and reach of children.

Dapanorm Trio Tablet is a combination medication used to manage Type 2 Diabetes Mellitus. It contains three active ingredients: Dapagliflozin, Sitagliptin, and Metformin, which work together to help control blood sugar levels.

Here are some frequently asked questions about Dapanorm Trio Tablet:

What is Dapanorm Trio Tablet used for?

Dapanorm Trio Tablet is prescribed for adults with Type 2 Diabetes Mellitus to help lower blood sugar levels, typically when diet and exercise alone are not sufficient, or when metformin alone doesn't provide adequate control. It works as an adjunct to diet and exercise and may also offer additional benefits such as modest weight loss and protection for the heart and kidneys in some patients.

How does Dapanorm Trio Tablet work?

Dapanorm Trio Tablet combines three medicines, each with a distinct mechanism of action:

• Dapagliflozin: This is a Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitor that works in the kidneys to remove excess sugar from the body through urine, thereby lowering blood glucose levels.
• Sitagliptin: As a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, it increases the levels of natural substances called incretins. These incretins help the pancreas release more insulin when blood sugar is high and reduce the amount of sugar produced by the liver.
• Metformin: This biguanide reduces the production of glucose by the liver, delays the absorption of sugar from the intestines, and improves the body's sensitivity to insulin, allowing cells to use glucose more effectively.

What is the usual dosage of Dapanorm Trio Tablet?

The dosage of Dapanorm Trio Tablet is determined by your doctor based on your individual needs and blood sugar control. It is generally taken orally, as advised by your doctor. You should swallow the tablet whole with a glass of water, without crushing, chewing, or breaking it. It can be taken with or without food, but it is recommended to take it at the same time each day to maintain consistent blood levels of the medication.

What are the possible side effects of Dapanorm Trio Tablet?

Common side effects may include vomiting, nausea, abdominal pain, headache, stomach upset, urinary tract infections (UTIs), nasal congestion, sore throat, upper respiratory tract infections, genital mycotic infections (yeast infections), and diarrhea. Some individuals may experience low blood sugar (hypoglycemia), especially if taken with other antidiabetic medicines, alcohol, or if meals are delayed or skipped. A rare but serious side effect due to metformin accumulation is lactic acidosis. If any side effects persist or worsen, consult your doctor.

Is Dapanorm Trio Tablet safe during pregnancy or breastfeeding?

Pregnancy: Dapanorm Trio Tablet is generally not recommended during pregnancy due to limited information on its effects and potential harm to the baby. If you are pregnant or planning a pregnancy, inform your doctor before taking this medicine. Breastfeeding: It is generally not recommended during breastfeeding, as it is unknown if the components pass into human breast milk. Discuss with your doctor if you are breastfeeding.

Can Dapanorm Trio Tablet be taken with other medications?

It is crucial to inform your doctor about all other medicines, including prescription drugs, over-the-counter medicines, herbal supplements, and vitamins you are currently taking or might take. Certain medications can interact with Dapanorm Trio Tablet, potentially affecting its effectiveness or increasing the risk of side effects. These include diuretics (water pills), other antidiabetic medicines (like insulin or sulfonylureas), certain antifungals (e.g., ketoconazole, itraconazole), antibacterials (e.g., clarithromycin), HIV medications (e.g., ritonavir), corticosteroids, and some cationic medicines (e.g., digoxin, amiloride).

What precautions should be taken while taking Dapanorm Trio Tablet?

Do not take Dapanorm Trio Tablet if you are allergic to any of its components. It is not recommended for patients with severe liver or kidney disease. Caution is advised for individuals with hepatic insufficiency or renal impairment due to an increased risk of lactic acidosis. Avoid excessive alcohol intake while on this medication, as it can increase the risk of lactic acidosis or diabetic ketoacidosis. It is important to stay well-hydrated while taking this medicine. This medicine is not for Type 1 diabetes or diabetic ketoacidosis. Your doctor will monitor your blood sugar levels and kidney function regularly during treatment.

What happens if a dose is missed?

If you miss a dose of Dapanorm Trio Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Dapanorm Trio Tablet be stored?

Store Dapanorm Trio Tablet in a cool and dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children and pets. It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.