Dabiclot 150 Mg Capsule (10 Cap)

DABICLOT 150 MG CAPSULE (10 CAP) by ALKEM LABORATORIES LTD.

Name

• Brand Name: Dabiclot 150mg Capsule
• Common Name: Dabigatran Etexilate

Composition

• Active Ingredient: Each capsule contains Dabigatran Etexilate 150mg (as mesilate salt). This medication acts as a direct thrombin inhibitor, preventing blood clot formation by blocking the enzyme thrombin, which is crucial for the clotting process.

Uses

Dabiclot 150mg Capsule is an anticoagulant primarily used to prevent and treat blood clots. It is prescribed for:

• Reducing the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (irregular heart rhythm).
• Treatment of acute deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Prevention of recurrence of DVT and PE.
• Prevention of venous thromboembolic events in patients who have undergone orthopedic surgeries, such as hip or knee replacement.

Dosage and Administration

Typically, Dabiclot 150mg Capsule is taken twice daily. Swallow the capsule whole with water; do not chew or crush it. It can be taken with or without food. For consistent therapeutic effect, take the medicine at the same time each day. Do not discontinue or alter the dose without consulting your doctor, as this may increase the risk of serious complications.

Side Effects

• Common Side Effects: Nausea, anemia, gastrointestinal bleeding, indigestion (dyspepsia), diarrhea, abdominal pain, nosebleeds, and skin bruising.
• Serious Side Effects: Bleeding from various sites (e.g., joints, rectum, brain), severe headaches, seizures, allergic reactions, changes in eyesight, and fatigue. Report any signs of excessive bleeding, such as weakness, dizziness, or unexplained swelling, to your doctor immediately.

Precautions

• Dabiclot increases the risk of bleeding; exercise caution during activities that might cause injury.
• Avoid alcohol consumption as it can heighten the risk of bleeding.
• Inform your doctor if you have kidney or liver problems, active bleeding disorders, or stomach ulcers.
• Concomitant use with other blood thinners (e.g., warfarin, aspirin, NSAIDs) can further increase bleeding risk.
• Not recommended during pregnancy or breastfeeding unless specifically advised by a doctor.
• If you are scheduled for surgery or dental treatment, your doctor might instruct you to temporarily stop taking this medication.

Storage

Store Dabiclot 150mg Capsule in its original packaging at room temperature, typically between 15°C and 30°C (or 20°C to 25°C), protected from moisture and direct sunlight. Keep the medicine out of reach of children. Once opened, use within 4 months.

DABICLOT 150 MG CAPSULE (containing Dabigatran Etexilate) is an anticoagulant medication used to prevent and treat blood clots. Here are some frequently asked questions about this medicine:

What is DABICLOT 150 mg Capsule used for?

DABICLOT 150 mg Capsule is primarily used to prevent and treat blood clots. It is prescribed to reduce the risk of stroke and systemic embolism in individuals with non-valvular atrial fibrillation (irregular heartbeat). It is also used for the treatment and prevention of deep vein thrombosis (DVT), blood clots in the leg veins, and pulmonary embolism (PE), blood clots in the lungs. Additionally, it helps prevent blood clots from forming after hip or knee replacement surgery.

How does DABICLOT 150 mg Capsule work?

DABICLOT 150 mg Capsule contains Dabigatran etexilate, which is a direct thrombin inhibitor. It works by directly blocking the activity of thrombin, a key enzyme in the blood clotting process. By inhibiting thrombin, it prevents the conversion of fibrinogen to fibrin, thereby reducing the formation and growth of blood clots. This action helps to keep blood flowing smoothly.

What is the usual dosage for DABICLOT 150 mg Capsule?

For adults, the typical dosage for stroke prevention in non-valvular atrial fibrillation is 150 mg taken twice daily, with or without food. For the treatment and prevention of deep vein thrombosis and pulmonary embolism, the usual dose is also 150 mg twice daily. The capsules should be swallowed whole with a glass of water and not crushed, chewed, or opened. Your doctor will determine the appropriate dosage and duration of treatment based on your medical condition and kidney function.

What are the possible side effects of DABICLOT 150 mg Capsule?

The most common and serious side effect of DABICLOT is bleeding, which can manifest as nosebleeds, skin bleeding, or gastrointestinal bleeding. Other common side effects include anemia (low number of red blood cells), nausea, stomach pain, indigestion (dyspepsia), and diarrhea. If you experience persistent or severe side effects, especially any signs of unusual or prolonged bleeding, you should consult your doctor immediately.

Is DABICLOT 150 mg Capsule safe during pregnancy or breastfeeding?

DABICLOT 150 mg Capsule is generally not recommended during pregnancy, as it may increase the risk of severe bleeding and could potentially harm the developing fetus. Women of childbearing potential should take measures to avoid becoming pregnant while on this medication. Regarding breastfeeding, caution is advised, and it is generally not recommended. While some data suggest low transfer into breast milk, and clinically significant levels in the infant are unlikely, it's best to consult your doctor, who will weigh the potential benefits against the risks.

Can DABICLOT 150 mg Capsule be taken with other medications?

DABICLOT can interact with other medications, potentially increasing the risk of bleeding. It is crucial to inform your doctor about all other medicines you are taking, including over-the-counter drugs, herbal supplements, and other anticoagulants or antiplatelet agents (e.g., warfarin, aspirin, NSAIDs). Certain medications, such as some P-glycoprotein inhibitors (e.g., systemic ketoconazole, dronedarone, cyclosporine) and inducers (e.g., rifampicin, carbamazepine, phenytoin), can significantly affect the levels of dabigatran in your body.

What precautions should be taken while taking DABICLOT 150 mg Capsule?

It is important to be aware of an increased risk of bleeding while taking DABICLOT. Inform your doctor if you have kidney or liver problems, stomach ulcers, high blood pressure, or any bleeding disorders. Avoid activities that may lead to injury or bleeding. Do not stop taking DABICLOT abruptly without consulting your doctor, as this can increase your risk of blood clots and stroke. Alcohol consumption should be limited or avoided as it may further increase the risk of bleeding. You may need to temporarily stop this medication before any surgical procedures.

What happens if a dose of DABICLOT 150 mg Capsule is missed?

If you miss a dose of DABICLOT, take it as soon as you remember. However, if it is less than 6 hours before your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects.

How should DABICLOT 150 mg Capsule be stored?

DABICLOT 150 mg Capsules should be stored at room temperature, typically between 15°C and 30°C (59°F and 86°F), in a cool, dry place. Protect the capsules from moisture and direct sunlight. Keep the bottle tightly closed and out of the reach of children. Once the bottle is opened, it should generally be used within 4 months; any unused capsules after this period should be safely discarded.