Metolar Trio 25 Tab

METOLAR TRIO 25 Tablet

METOLAR TRIO 25 Tablet is a combination medication manufactured by Cipla Ltd, primarily prescribed for the management of high blood pressure.

• Name: Metolar Trio 25 Tablet

• Composition: Each film-coated tablet contains:

  • Metoprolol Succinate (as extended release, equivalent to Metoprolol Tartrate 25 mg)
  • Cilnidipine 10 mg
  • Telmisartan 40 mg

• Uses: METOLAR TRIO 25 Tablet is indicated for the treatment of essential hypertension (high blood pressure). It helps reduce the risk of associated cardiovascular complications such as heart attack, stroke, kidney damage, angina (chest pain), and uneven heartbeat (arrhythmia). It is particularly beneficial for patients with additional conditions like diabetes or an increased risk of cardiovascular diseases.

• Dosage and Administration: The typical recommended oral dosage is one tablet once daily, or as directed by a physician. The dosage should be individualized based on the patient's condition and response to treatment. The tablet should be swallowed whole with liquid and must not be chewed, crushed, or broken. It is advisable to take the medicine at the same time each day, preferably with or immediately after meals, for optimal results.

• Side Effects:

  • Common: Dizziness, fatigue, headache, nausea, swelling of the ankles or other body parts (edema), low blood pressure (hypotension), slow heart rate (bradycardia), cold hands and feet, flushing, stomach pain, vomiting, diarrhea, constipation, and weakness.
  • Serious: Severe allergic reactions (e.g., skin rash, itching, swelling of face/lips/throat, difficulty breathing), severe skin reactions (e.g., blistering, peeling), sepsis, very slow heartbeat, fainting, sudden chest pain, trouble breathing, yellowing of the skin or eyes, or unusual tiredness. Seek immediate medical attention if any serious side effects occur.

• Precautions:

  • METOLAR TRIO 25 Tablet is contraindicated in patients with known hypersensitivity to its ingredients, very low blood pressure, certain heart rhythm problems (e.g., second or third-degree heart block, sick sinus syndrome), severe heart failure, severe asthma, or in the second and third trimesters of pregnancy.
  • Use with caution in patients with liver disease, kidney disease, diabetes, thyroid problems, asthma, or chronic obstructive pulmonary disease (COPD).
  • Avoid alcohol consumption as it may increase dizziness and further lower blood pressure.
  • Do not discontinue the medication abruptly without consulting a doctor, as it can lead to a sudden increase in blood pressure or worsen heart conditions.
  • Patients should inform their doctor about all other medications, supplements, or herbal products they are taking, especially diuretics, NSAIDs, antidepressants, and potassium supplements, to avoid potential interactions.
  • Due to potential dizziness, exercise caution when driving or operating heavy machinery.

• Storage: Store METOLAR TRIO 25 Tablet at room temperature, not exceeding 30°C. Protect the tablets from light and moisture, and keep them in their original packaging. Ensure the medicine is kept out of the sight and reach of children. Do not use the medicine after its expiry date.

What is Metolar Trio 25 Tablet used for?

Metolar Trio 25 Tablet is primarily used to manage high blood pressure (hypertension). This combination medication helps to lower blood pressure, thereby reducing the risk of serious complications such as heart attack, stroke, and kidney damage. It is particularly beneficial for patients who may require multiple medications for blood pressure control or those with additional conditions like diabetes or increased cardiovascular risk. It is also indicated for stable ischemic heart disease.

How does Metolar Trio 25 Tablet work?

Metolar Trio 25 Tablet contains three active ingredients: Metoprolol Succinate, Cilnidipine, and Telmisartan, which work together to lower blood pressure.

• Telmisartan is an angiotensin II receptor blocker (ARB) that relaxes and widens blood vessels, promoting vasodilation and reducing vasoconstriction.
• Cilnidipine is an L/N-type calcium channel blocker that relaxes blood vessels and reduces peripheral vascular resistance.
• Metoprolol Succinate is a beta-blocker that slows the heart rate and reduces the force of heart contractions, making it easier for the heart to pump blood throughout the body.

What is the usual dosage for Metolar Trio 25 Tablet?

The recommended oral dosage is typically one tablet once daily, or as prescribed by your doctor. The exact dosage is individualized based on factors such as age, the severity of your condition, and your response to treatment. It is recommended to take the tablet at a fixed time each day, with or without food. Swallow the tablet whole without crushing or breaking it.

What are the possible side effects of Metolar Trio 25 Tablet?

Common side effects may include headache, nausea, dizziness, weakness, decreased blood pressure, slow heart rate, fatigue, ankle swelling, flushing (a sensation of warmth), diarrhea, and constipation. Most of these side effects are usually temporary and resolve on their own. However, if you experience any severe or persistent side effects, or signs of a serious allergic reaction (such as skin rash, itching, swelling of the face, lips, or throat, or difficulty breathing), or severe skin reactions, seek immediate medical attention.

Is Metolar Trio 25 Tablet safe during pregnancy or breastfeeding?

Pregnancy: Metolar Trio 25 Tablet is generally not recommended during pregnancy, especially in the second and third trimesters, as it may harm the developing baby. Angiotensin II receptor antagonists, like Telmisartan, should not be initiated during pregnancy. You should consult your doctor for safer alternative treatments if you are pregnant or planning to conceive. Breastfeeding: It is important to seek medical advice before using this medication if you are breastfeeding. Telmisartan is not recommended during breastfeeding due to a lack of safety data and potential risks, particularly for newborns or preterm infants. While Metoprolol is excreted in breast milk, it is typically in small amounts. Cilnidipine's presence in breast milk is not known, but caution is advised.

Can Metolar Trio 25 Tablet be taken with other medications?

It is crucial to inform your doctor about all other medications, supplements, or herbal products you are currently taking to avoid potential drug interactions.

• Caution is advised with diuretics (e.g., furosemide, hydrochlorothiazide) due to an increased risk of low blood pressure and electrolyte imbalances.
• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce the blood pressure-lowering effect and increase the risk of kidney impairment.
• Antidepressants such as fluoxetine or paroxetine may increase the levels of metoprolol in the body, potentially leading to side effects.
• Co-administration with aliskiren is not recommended, especially in patients with diabetes or kidney impairment.
• Other medications like catecholamine-depleting drugs, potassium-sparing diuretics, potassium supplements, and certain medicines for epilepsy, bacterial infections, tuberculosis, or heart conditions may also interact.

What precautions should be taken while taking Metolar Trio 25 Tablet?

Before taking Metolar Trio 25 Tablet, inform your doctor if you have any pre-existing health conditions such as diabetes, circulation problems, asthma, thyroid disorder, adrenal gland tumor, or liver or kidney problems.

• Avoid alcohol consumption as it can further lower blood pressure and increase side effects like dizziness.
• Do not stop taking this medicine abruptly, as it can lead to a sudden increase in blood pressure, chest pain, or even a heart attack. Your doctor will advise on gradual discontinuation if needed.
• Since this medication may cause dizziness or fatigue, avoid driving or operating heavy machinery until you know how it affects you.
• Rise slowly from a lying or sitting position to prevent dizziness due to a sudden drop in blood pressure (orthostatic hypotension).
• Regular monitoring of blood pressure, kidney function, blood sugar levels, and electrolytes may be recommended by your doctor.
• It is not recommended for children, and elderly patients should use it with caution.

What happens if a dose of Metolar Trio 25 Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Metolar Trio 25 Tablet be stored?

Metolar Trio 25 Tablet should be stored at room temperature, typically below 30°C (or 25°C). Keep it protected from light and moisture, and ensure it is kept out of the sight and reach of children. Do not use the medicine after its expiry date.