Tonact Ez 40 Mg Tablets

TONACT EZ 40 MG TABLETS is a combination medication manufactured by Lupin Ltd., containing Atorvastatin and Ezetimibe. This medicine is primarily used to manage high cholesterol levels and reduce the risk of cardiovascular events.

Name

• Brand Name: TONACT EZ 40 MG TABLETS
• Common Names: Atorvastatin and Ezetimibe

Composition

Each tablet contains:

• Atorvastatin: 40 mg
• Ezetimibe: 10 mg

Uses

TONACT EZ 40 MG TABLETS are prescribed for:

• Management of primary hypercholesterolemia (high cholesterol in the blood).
• Lowering "bad" cholesterol (LDL) and triglycerides.
• Raising "good" cholesterol (HDL).
• Reducing the risk of heart attack and stroke.
• Used in conjunction with a proper diet and lifestyle changes.

Dosage and Administration

• Take TONACT EZ 40 MG TABLETS as advised by your physician, usually once daily.
• It can be taken with or without food.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Taking it at the same time every day helps maintain consistent blood levels.
• The dose and duration of treatment will be determined by your doctor. Do not stop taking it until you have finished the complete course, even if you feel better.

Side Effects

Common Side Effects:

• Joint pain
• Diarrhoea
• Headache
• Fatigue
• Muscle pain or weakness
• Nausea
• Constipation
• Tendon problems
• Memory loss, confusion, depression
• Upper respiratory tract infection, cough, influenza

Serious Side Effects (Rare):

• Severe muscle pain, tenderness, or weakness (rhabdomyolysis), especially with fever
• Liver problems (symptoms include yellowing of skin/eyes, dark urine, loss of appetite, upper belly pain, persistent nausea, or vomiting)
• Serious allergic reactions (swelling of face, lips, tongue, and/or throat that may cause difficulty breathing or swallowing, rash, itching, severe dizziness)
• Unexplained bleeding or bruising
• Kidney problems (change in amount of urine)
• Shortness of breath that may suggest lung problems

Precautions

• Contraindications: Not recommended for use in pregnant or breastfeeding women. Avoid if you have active liver disease, unexplained persistent elevations in liver enzyme levels, an allergy to its ingredients, or if you are taking certain hepatitis C medicines (like glecaprevir or pibrentasvir).
• Warnings:
  • Use with caution in patients with kidney or liver problems.
  • Inform your doctor if you have thyroid problems, diabetes, or unexplained muscle aches or weakness.
  • Avoid or limit alcohol consumption as it can increase the risk of liver problems.
  • Avoid grapefruit or grapefruit juice and red yeast rice while taking this medicine, as it may increase the risk of side effects.
• Drug Interactions: Inform your doctor about all medicines, supplements, or herbal products you are taking, especially cholestyramine, colestipol, gemfibrozil, daptomycin, telithromycin, birth control pills, medicines for heart failure, antifungals (e.g., itraconazole, ketoconazole), HIV protease inhibitors, immunosuppressants (e.g., cyclosporine), certain antidepressants (e.g., nefazodone), blood thinners, antacids, antihypertensive medicines, and painkillers.
• Driving: Do not drive or operate machines if you experience dizziness after taking this medicine.
• Lifestyle: Maintain a cholesterol-friendly diet (low-fat, high-fiber), regular exercise, and consider quitting smoking to enhance effectiveness.

Storage

• Store below 30°C in a cool and dry place.
• Protect from moisture and direct sunlight.
• Keep the medication in its original container, tightly closed, and out of reach of children and pets.
• Do not flush unused tablets or discard them in household waste.

What is TONACT EZ 40 MG TABLETS used for?

TONACT EZ 40 MG TABLETS is primarily used to treat high cholesterol levels (hypercholesterolemia) by lowering "bad" cholesterol (LDL) and triglycerides, and increasing "good" cholesterol (HDL) in the blood. It is also prescribed to reduce the risk of cardiovascular events such as heart attack and stroke, and to manage conditions like mixed dyslipidemia and atherosclerosis (fatty deposits in arteries).

How does TONACT EZ 40 MG TABLETS work?

This medicine is a combination of two active ingredients: Atorvastatin and Ezetimibe. Atorvastatin belongs to a class of drugs called statins, which work by inhibiting an enzyme in the liver (HMG-CoA reductase) responsible for producing cholesterol. Ezetimibe works by inhibiting the absorption of cholesterol from the small intestine. Together, they offer a dual-action approach to comprehensively reduce cholesterol levels.

What is the usual dosage of TONACT EZ 40 MG TABLETS?

TONACT EZ 40 MG TABLETS is typically taken once daily, with or without food, at the same time each day to maintain consistent levels in your system. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. Your doctor will determine the exact dose and duration of treatment based on your individual needs and medical condition.

What are the possible side effects of TONACT EZ 40 MG TABLETS?

Common side effects may include muscle pain (myalgia), headache, nausea, stomach pain, constipation, diarrhea, upper respiratory tract infection, increased liver enzymes, increased blood glucose levels, dizziness, fatigue, and joint pain. Serious but rare side effects can include severe muscle pain or cramps (rhabdomyolysis), liver damage (indicated by yellowing of the skin or eyes, or dark urine), and severe allergic reactions. It is important to consult your doctor if you experience any unusual or persistent symptoms.

Is TONACT EZ 40 MG TABLETS safe during pregnancy or breastfeeding?

TONACT EZ 40 MG TABLETS is generally considered unsafe and not recommended for use during pregnancy. Women of childbearing potential should use effective contraceptive methods while taking this medicine. It is also not recommended during breastfeeding, as the components may pass into breast milk and could potentially harm a nursing infant.

Can TONACT EZ 40 MG TABLETS be taken with other medications?

Yes, but it's crucial to inform your doctor about all prescription and non-prescription medicines, supplements, and herbal products you are currently taking or plan to take. TONACT EZ 40 MG TABLETS can interact with certain medications, including anti-HIV medicines, antibiotics, antifungals, anti-convulsants, blood thinners (like warfarin), certain hepatitis C medicines (e.g., glecaprevir or pibrentasvir), and other cholesterol-lowering agents such as fibrates (e.g., gemfibrozil, fenofibrate) and niacin. These interactions can affect how the medicine works or increase the risk of side effects.

What precautions should be taken while on TONACT EZ 40 MG TABLETS?

Before starting treatment, inform your doctor if you have any pre-existing medical conditions, especially liver or kidney problems, thyroid issues, muscle disorders, or diabetes. You should avoid consuming large amounts of grapefruit or grapefruit juice, as it can affect the metabolism of the medicine. Excessive alcohol consumption should also be avoided due to an increased risk of liver damage. Regular monitoring of liver function and cholesterol levels will be necessary during treatment. Report any unexplained muscle pain or weakness to your doctor immediately.

What happens if a dose of TONACT EZ 40 MG TABLETS is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should TONACT EZ 40 MG TABLETS be stored?

TONACT EZ 40 MG TABLETS should be stored below 30°C in a cool and dry place, away from direct sunlight. It is important to keep this medicine out of the sight and reach of children.