Lupisit Dm 10/100/1000mg Tab

LUPISIT DM 10/100/1000MG Tablet is a combination medication prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used as an adjunct to diet and exercise to achieve better blood sugar control, especially when single or dual therapies are insufficient. This medication works to lower blood glucose levels and may also offer benefits for weight management and cardiovascular and kidney protection.

Name

• Brand Name: LUPISIT DM 10/100/1000MG Tablet
• Manufacturer: Lupin Ltd.

Composition Each tablet contains the following active ingredients:

• Dapagliflozin: 10 mg
• Sitagliptin: 100 mg
• Metformin: 1000 mg

Uses LUPISIT DM is primarily used for:

• Treatment of Type 2 Diabetes Mellitus in adults to improve blood sugar control.
• Reducing the risk of serious complications associated with diabetes, such as kidney damage, eye damage, nerve problems, and cardiovascular events.

Dosage and Administration

• Take LUPISIT DM exactly as advised by your physician.
• The tablet can be taken with or without food; however, taking it with meals may help minimize gastrointestinal discomfort.
• Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
• For optimal benefits, it is recommended to take the medicine at the same time each day. Do not stop taking this medicine without consulting your doctor.

Side Effects

• Common Side Effects: Hypoglycemia (low blood glucose level), nausea, vomiting, abdominal pain, headache, flatulence, genital infections, increased or more frequent urination, drowsiness, dizziness, diarrhea, constipation, dry mouth, decreased weight, and thirst.
• Serious Side Effects (Seek immediate medical attention if experienced): Signs of lactic acidosis (weakness, difficulty breathing, severe stomach pain), symptoms of ketoacidosis (nausea, vomiting, confusion, fruity breath), painful or persistent genital or urinary infections, symptoms of acute pancreatitis (severe and persistent abdominal pain that may radiate to the back with or without nausea and vomiting), severe allergic reactions (rash, hives, swelling of the face/lips/tongue/throat leading to difficulty breathing or swallowing), or blistering of the skin (bullous pemphigoid).

Precautions

• Contraindications: Do not take if allergic to any of the components. Not recommended for patients with Type 1 diabetes, severe kidney disease, liver disease, heart failure, respiratory failure, acute metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis), diabetic pre-coma, dehydration, severe infection, or shock.
• Specific Conditions: Use with caution in patients with kidney or liver problems, as it may increase the risk of lactic acidosis.
• Pregnancy and Breastfeeding: LUPISIT DM is generally not recommended during pregnancy or for breastfeeding women. Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.
• Drug Interactions: Inform your doctor about all current medications, including prescription, over-the-counter, and herbal supplements. Caution is advised when used with other antidiabetic medications (sulfonylureas, insulin) due to an increased risk of hypoglycemia. Interactions may occur with diuretics, certain heart medications (e.g., digoxin), and some antifungals (e.g., ketoconazole, itraconazole), antibacterials (e.g., clarithromycin), or antivirals (e.g., ritonavir).
• Alcohol: Avoid excessive alcohol consumption as it can increase the risk of certain side effects, including lactic acidosis.
• General Advice: Maintain a healthy diet, engage in regular exercise, and manage weight as advised by your doctor. Monitor your blood sugar levels regularly. Maintain good personal hygiene to help prevent genital fungal infections. Drink plenty of fluids to prevent dehydration.

Storage

• Store in a cool, dry place, away from direct sunlight.
• Keep the medicine out of the sight and reach of children.
• Store below 30°C.

What is Lupisit DM 10/100/1000mg Tablet used for?

Lupisit DM 10/100/1000mg Tablet is an antidiabetic medicine used to treat Type 2 Diabetes Mellitus in adults. It is prescribed as an adjunct to diet and exercise to help improve blood sugar control. This medication also helps reduce the risk of diabetes-related complications such as kidney damage, eye damage, and nerve problems, and may offer cardiovascular and kidney protective benefits.

How does Lupisit DM 10/100/1000mg Tablet work?

Lupisit DM 10/100/1000mg Tablet is a combination of three active ingredients: Dapagliflozin, Sitagliptin, and Metformin, which work synergistically to control blood sugar levels.

• Dapagliflozin (10mg) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that removes excess sugar from the body through urine by preventing its reabsorption in the kidneys.
• Sitagliptin (100mg) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of natural substances (incretins) which, in turn, increase insulin release and decrease glucagon levels when blood sugar is high.
• Metformin (1000mg) is a biguanide that reduces the production of sugar by the liver, delays the absorption of sugar from the intestines, and improves the body's sensitivity to insulin.

What is the usual dosage for Lupisit DM 10/100/1000mg Tablet?

You should take Lupisit DM 10/100/1000mg Tablet exactly as advised by your doctor. It can be taken with or without food, but it is recommended to take it at the same time each day for optimal benefits. Swallow the tablet whole with a glass of water; do not crush, break, or chew it. Your doctor will determine the correct dose and duration of treatment based on your age, body weight, and medical condition. Do not stop taking this medicine without consulting your doctor.

What are the possible side effects of Lupisit DM 10/100/1000mg Tablet?

Common side effects may include hypoglycemia (low blood sugar), nausea, vomiting, abdominal pain, headache, flatulence, genital infections, increased or more frequent urination, drowsiness, dizziness, diarrhea, constipation, dry mouth, decreased weight, and thirst. Urinary tract infections, nasal congestion, and sore throat are also commonly reported.

Serious but rare side effects that require immediate medical attention include signs of lactic acidosis (weakness, difficulty breathing, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), acute pancreatitis (severe and persistent abdominal pain), and severe allergic reactions (rash, swelling of the face, lips, tongue, or throat, difficulty breathing).

Is Lupisit DM 10/100/1000mg Tablet safe during pregnancy or breastfeeding?

Lupisit DM 10/100/1000mg Tablet is generally not recommended during pregnancy due to limited information on its effects in pregnant women. If you are pregnant or planning to become pregnant, inform your doctor before taking this medicine. Similarly, it is generally not recommended while breastfeeding, as it is unknown if the components pass into human breast milk. Inform your doctor if you are breastfeeding.

Can Lupisit DM 10/100/1000mg Tablet be taken with other medications?

It is crucial to inform your doctor about all other medicines, herbal products, or supplements you are currently taking or plan to take to avoid potential drug interactions.

Particular caution should be exercised if you are taking:

• Insulin or insulin secretagogues (e.g., sulfonylureas), as this combination may significantly lower blood sugar levels.
• Diuretics (water pills like furosemide, hydrochlorothiazide), which can increase the risk of dehydration and low blood pressure.
• Certain medications for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), or HIV/AIDS (e.g., ritonavir).
• Medications for heart failure (e.g., digoxin), blood pressure drugs, or steroids.
• Beta-blockers, as they may mask the symptoms of hypoglycemia.

What precautions should be taken while taking Lupisit DM 10/100/1000mg Tablet?

Avoid taking Lupisit DM 10/100/1000mg Tablet if you are allergic to any of its components. It is not recommended for individuals with severe liver or kidney disease, respiratory failure, Type 1 diabetes, acute metabolic acidosis (like lactic acidosis or diabetic ketoacidosis), diabetic pre-coma, dehydration, severe infection, or shock.

Use with caution if you have mild to moderate kidney disease, hepatic insufficiency, or a urinary tract infection. Avoid excessive alcohol consumption, as it can increase the risk of hypoglycemia and lactic acidosis. Regular monitoring of blood sugar levels is important during treatment. Maintaining good hygiene can help prevent genital fungal infections. This medicine is not recommended for use in children below 18 years of age.

Always carry a source of fast-acting sugar (such as glucose tablets or hard candy) in case you experience symptoms of low blood sugar.

What happens if a dose of Lupisit DM 10/100/1000mg Tablet is missed?

If you miss a dose of Lupisit DM 10/100/1000mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. It is important not to stop the medication abruptly, as this can lead to an increase in blood sugar levels and potential complications.

How should Lupisit DM 10/100/1000mg Tablet be stored?

Store Lupisit DM 10/100/1000mg Tablet in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children and pets. The medicine should be stored at temperatures below 30°C.