Dapamac M 10 Mg/500 Mg Tablet (15 Tab)

DAPAMAC M 10 MG/500 MG TABLET

Name

• Brand Name: DAPAMAC M 10 MG/500 MG TABLET
• Common Name: Dapagliflozin and Metformin
• Manufacturer: Macleods Pharmaceuticals Ltd.

Composition Each tablet contains:

• Dapagliflozin: 10 mg
• Metformin: 500 mg

Uses Dapamac M 10 mg/500 mg Tablet is prescribed for adults to manage:

• Type 2 Diabetes Mellitus: Used as an adjunct to diet and exercise to improve blood sugar control.
• Reduction of Cardiovascular Risk:
  • To reduce the risk of hospitalization for heart failure in adults with Type 2 Diabetes and established cardiovascular disease or multiple cardiovascular risk factors.
  • To reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in patients with heart failure.
  • To lower the risk of worsening kidney disease, end-stage kidney disease, and cardiovascular death in patients with chronic kidney disease (CKD) at risk of progression.
• May be used in combination with insulin or GLP-1 receptor agonists.

Dosage and Administration

• Take this medicine with meals or as advised by your doctor.
• It is typically taken once daily.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• The dosage and duration of treatment are determined by your doctor based on your medical condition and response.
• Do not stop taking the medication without consulting your doctor, as abrupt discontinuation can lead to increased blood sugar levels and potential complications. The maximum daily dose should not exceed 10 mg of dapagliflozin and 2000 mg of metformin.

Side Effects

• Common Side Effects: Nausea, vomiting, diarrhea, headache, dizziness, frequent urination, mild skin rash, itchy skin, stomach ache, loss of appetite, sore throat, nasal congestion, runny nose, genital fungal infections (e.g., vaginal yeast infections, penile yeast infections), and urinary tract infections.
• Serious Side Effects (Seek immediate medical attention if experienced):
  • Dehydration: Symptoms include increased thirst, dry mouth, feeling faint or lightheaded, and dark yellow or brown urine.
  • Lactic Acidosis: A rare but serious condition with symptoms like muscle pain or cramps, stomach pain, trouble breathing, general discomfort and fatigue, unusual sleepiness or tiredness, low body temperature, low heart rate, and low blood pressure.
  • Diabetic Ketoacidosis (DKA): Increased thirst or urination, dry mouth, fatigue, fruity odor to breath, trouble breathing, stomach pain, nausea, and vomiting.
  • Severe Urinary Tract Infections: Such as urosepsis or pyelonephritis.
  • Hypoglycemia (Low Blood Sugar): Especially when used with other antidiabetic medicines, characterized by shakiness, dizziness, sweating, confusion, and rapid heartbeat.
  • Allergic Reactions: Skin rash, hives, swelling of the face, lips, tongue, or throat.
  • Fournier's Gangrene: A rare but life-threatening bacterial infection of the genital area.

Precautions

• This medicine is not for treating Type 1 Diabetes Mellitus or diabetic ketoacidosis.
• Not recommended for individuals with severe kidney or liver disease.
• Use with caution in patients with heart problems, including a history of heart attack or heart failure.
• Avoid alcohol consumption as it can increase the risk of lactic acidosis and low blood sugar.
• Pregnancy: Dapagliflozin is generally not recommended during the second and third trimesters of pregnancy; consult your doctor if you are pregnant or planning to conceive.
• Breastfeeding: This medicine may be unsafe during breastfeeding as it may pass into breast milk; consult your doctor.
• Stay well-hydrated, especially in hot weather, during physical activity, or if experiencing fever, infection, vomiting, or diarrhea, to prevent dehydration.
• Be aware of the risk of hypoglycemia (low blood sugar), particularly when this medication is used with insulin or insulin secretagogues; dosage adjustments of other diabetes medications may be necessary.
• Regular monitoring of kidney function is recommended while on this medication.
• Your ability to drive may be affected if your blood sugar levels are too high or too low.
• Inform your doctor if you are scheduled for surgery or imaging scans (e.g., CT or X-ray), as you may need to temporarily stop taking this medicine.
• Metformin may decrease Vitamin B12 levels; your doctor may recommend monitoring and supplementation.
• Practice good genital hygiene to help prevent fungal infections.

Storage

• Store in a cool and dry place away from direct sunlight.
• Keep out of sight and reach of children.
• Store below 30°C or at room temperature, away from moisture and heat.

DAPAMAC M 10 MG/500 MG TABLET is a medication used to manage type 2 diabetes mellitus in adults. It contains two active ingredients, Dapagliflozin and Metformin, which work together to help control high blood sugar levels.

Here are some frequently asked questions about DAPAMAC M 10 MG/500 MG TABLET:

What is DAPAMAC M 10 MG/500 MG TABLET used for?

DAPAMAC M 10 MG/500 MG TABLET is primarily used to treat type 2 diabetes mellitus in adults. It helps to lower high blood sugar levels when diet and exercise alone are not sufficient. Additionally, this medicine can reduce the risk of hospitalization due to heart failure in adults with type 2 diabetes who also have established cardiovascular disease or multiple cardiovascular risk factors. It may also help prevent serious diabetes complications such as kidney damage, blindness, and nerve damage.

How does DAPAMAC M 10 MG/500 MG TABLET work?

This tablet combines two antidiabetic medicines: Dapagliflozin and Metformin. Dapagliflozin is an SGLT-2 (sodium-glucose co-transporter-2) inhibitor that works by blocking the reabsorption of glucose in the kidneys, leading to increased excretion of excess sugar through the urine. Metformin, a biguanide, works by decreasing the production of glucose in the liver, delaying glucose absorption from the intestines, and improving the body's sensitivity to insulin. Together, these mechanisms provide better control of blood sugar levels.

What is the usual dosage for DAPAMAC M 10 MG/500 MG TABLET?

DAPAMAC M 10 MG/500 MG TABLET is typically taken once daily, usually in the morning. It can be taken with or without food, though taking it with food is often recommended to minimize gastrointestinal side effects. It is crucial to swallow the tablet whole without crushing, chewing, or breaking it. Your doctor will determine the appropriate dose and duration of treatment based on your medical condition and response. Consistency is key, so try to take it at the same time each day.

What are the possible side effects of DAPAMAC M 10 MG/500 MG TABLET?

Common side effects can include nausea, vomiting, diarrhea, stomach pain, loss of appetite, headache, dizziness, frequent urination, mild skin rash, itchy skin, and genital or urinary tract infections. While these are usually mild and resolve over time, you should inform your doctor if they persist or worsen. More serious, but rare, side effects can include lactic acidosis (with symptoms like severe tiredness, muscle cramps, difficulty breathing, and low blood pressure) and ketoacidosis. Seek immediate medical attention if you experience symptoms of a serious side effect.

Is DAPAMAC M 10 MG/500 MG TABLET safe during pregnancy or breastfeeding?

DAPAMAC M 10 MG/500 MG TABLET is generally not recommended during pregnancy, especially during the second and third trimesters. It may also be unsafe to use while breastfeeding as it can be excreted into breast milk. If you are pregnant, planning to conceive, or breastfeeding, you should consult your doctor to discuss the risks and benefits. Your doctor may suggest alternative medications to manage your blood sugar.

Can DAPAMAC M 10 MG/500 MG TABLET be taken with other medications?

It is important to inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential drug interactions. Taking DAPAMAC M 10 MG/500 MG TABLET with insulin or other diabetes medications (like sulfonylureas) may increase the risk of low blood sugar (hypoglycemia), requiring careful dosage adjustments and blood sugar monitoring by your doctor. Additionally, diuretics (water pills) may increase the risk of dehydration and low blood pressure. This medicine should not be used with certain injectable dyes used for X-rays. Other medications, such as carbonic anhydrase inhibitors and some cationic medicines, can also interact, potentially increasing the risk of side effects like lactic acidosis.

What precautions should be taken while on DAPAMAC M 10 MG/500 MG TABLET?

Do not take this medicine if you have type 1 diabetes, severe kidney or liver disease, diabetic ketoacidosis, a recent heart attack, heart failure, a severe infection, or uncontrolled diabetes. Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis and affect blood sugar levels. Staying well-hydrated is important to prevent dehydration. It is not recommended for individuals under 18 or those aged 85 or older. Regular monitoring of your blood sugar and kidney function is essential while taking this medication. Do not stop taking DAPAMAC M 10 MG/500 MG TABLET abruptly without consulting your doctor, as this can lead to an increase in blood sugar levels and a higher risk of complications. Your ability to drive may be affected if your blood sugar levels are too high or too low.

What happens if a dose of DAPAMAC M 10 MG/500 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should DAPAMAC M 10 MG/500 MG TABLET be stored?

DAPAMAC M 10 MG/500 MG TABLET should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children. The typical storage temperature is between 10ºC and 25ºC or below 30ºC.