APRAIZE 20 MG TABLET

Name

• Generic Name: Apremilast
• Brand Name: Apraize 20 mg Tablet

Composition

• Active Ingredient: Apremilast 20 mg per tablet

Uses

• Psoriasis: Indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy.
• Psoriatic Arthritis: Used to reduce signs and symptoms of active psoriatic arthritis in adults.

Dosage and Administration

• Typical Dosage:
  • The recommended initial dose is titrated over the first 5 days to reduce gastrointestinal side effects.
  • Day 1: 10 mg in the morning
  • Day 2: 10 mg in the morning and 10 mg in the evening
  • Day 3: 10 mg in the morning and 20 mg in the evening
  • Day 4: 20 mg in the morning and 20 mg in the evening
  • Day 5: 20 mg in the morning and 30 mg in the evening
  • Maintenance Dose: 30 mg twice daily thereafter
• Administration: Can be taken with or without food. Swallow the tablet whole with water.

Side Effects

• Common Side Effects:

  • Diarrhea
  • Nausea
  • Headache
  • Upper respiratory tract infections
  • Weight loss

• Serious Side Effects:

  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Depression or suicidal thoughts
  • Severe or persistent diarrhea, nausea, or vomiting

Precautions

• Psychiatric Disorders: Monitor for depression or suicidal ideation, especially in patients with a history of depression.
• Weight Loss: Regularly monitor body weight; discontinue if significant unexplained weight loss occurs.
• Drug Interactions: Use caution with strong CYP450 inducers (e.g., rifampin, phenytoin), which may reduce Apremilast effectiveness.
• Renal Impairment: Dose adjustment may be required in severe renal impairment.

Storage

• Store below 30°C (86°F).
• Keep in the original package to protect from moisture.
• Keep out of reach of children.

What is Apraize 20 mg Tablet used for?

Apraize 20 mg Tablet contains apremilast and is mainly used to treat moderate to severe plaque psoriasis and psoriatic arthritis in adults. It helps reduce symptoms such as scaling, redness, and joint pain.

How does Apraize work?

Apraize (apremilast) works by inhibiting an enzyme called phosphodiesterase 4 (PDE4), which results in reduced inflammation in the body. This helps to improve skin lesions and joint symptoms.

What is the usual dosage of Apraize 20 mg?

The typical dosage is determined by your doctor. Apraize is usually started at a lower dose and gradually increased over several days to minimize side effects. Always follow your healthcare provider’s instructions regarding dosage.

What are the possible side effects of Apraize?

Common side effects include diarrhea, nausea, headache, upper respiratory tract infections, and weight loss. Some people may experience depression or mood changes. Contact your doctor if you notice severe or persistent side effects.

Is Apraize safe during pregnancy or breastfeeding?

The safety of Apraize during pregnancy or breastfeeding has not been established. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this medication.

Can Apraize be taken with other medications?

Apraize may interact with certain medications, especially those that affect liver enzymes (such as rifampicin, phenytoin, carbamazepine, or St. John’s Wort). Inform your doctor about all the medicines and supplements you are taking.

What precautions should be taken while using Apraize?

Inform your doctor if you have a history of depression, mood disorders, severe kidney problems, or are underweight. Monitor for mood changes or unexplained weight loss during treatment.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.

How should Apraize 20 mg be stored?

Store Apraize tablets at room temperature, away from moisture and heat. Keep the medication out of reach of children. Do not use the tablets after the expiration date printed on the packaging.