Glucreta S 10+50 Tab

GLUCRETA S 10+50 Tablet

• Name:

  • Brand Name: GLUCRETA S 10+50 Tablet
  • Manufacturer: Torrent Pharmaceuticals Ltd.

• Composition:

  • Each tablet contains:
    • Dapagliflozin: 10 mg
    • Sitagliptin: 50 mg

• Uses: GLUCRETA S 10+50 Tablet is primarily used for the management of Type 2 Diabetes Mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by metformin monotherapy or other treatments. It helps to:

  • Improve blood sugar control.
  • Reduce the risk of serious diabetes-related complications, such as kidney damage (nephropathy), eye damage (retinopathy), nerve problems (neuropathy), diabetic foot ulcers, and delayed wound healing.
  • Lower the risk of heart attack, heart failure, or other cardiovascular events.
  • Treat chronic kidney disease in adults with reduced kidney function.

• Dosage and Administration:

  • Take GLUCRETA S 10+50 Tablet as advised by your physician.
  • Swallow the medicine whole with a glass of water; do not crush or chew.
  • It can be taken with or without food, but it is recommended to take it at the same time each day for optimal benefits.
  • Your doctor will determine the correct dose and duration of therapy based on your age, body weight, and disease condition. Do not stop taking the medicine without consulting your doctor.

• Side Effects:

  • Common Side Effects: Headache, dizziness, flatulence, constipation, stomach pain, diarrhea, swelling of hands or legs, stuffy or runny nose, sore throat, frequent urination, dry mouth, vaginal yeast infection, and upper respiratory tract infection.
  • Serious Side Effects (Seek immediate medical attention if you experience):
    • Inflamed pancreas (severe, persistent stomach pain).
    • Serious allergic reaction (rash, hives, blisters on the skin, swelling of lips, tongue, face, or throat causing difficulty in breathing or swallowing).
    • Necrotizing fasciitis of the perineum (Fournier's gangrene) (pain, tenderness, redness, or swelling in the genital area with fever).
    • Diabetic ketoacidosis (increased ketones, nausea or vomiting, stomach ache, excessive thirst, rapid weight loss).
    • Severe urinary tract infection (fever, chills, burning sensation during urination, back or side pain, blood in urine).
    • Low blood sugar levels (hypoglycemia), especially when used with other antidiabetic medicines.

• Precautions:

  • Contraindications: Not recommended for patients with Type 1 Diabetes Mellitus, diabetic ketoacidosis, severe kidney problems, or those on dialysis.
  • Medical History: Inform your doctor if you have a history of pancreatitis, gallstones, alcohol dependence, very high triglyceride levels, heart, kidney, or liver problems.
  • Pregnancy and Breastfeeding: Not recommended during pregnancy. Use with caution in breastfeeding women, only if considered clearly necessary, as it is not known if it passes into breast milk.
  • Interactions: Use with caution with other antidiabetic medicines (like sulfonylureas or insulin) due to increased risk of hypoglycemia. Diuretics may increase the risk of dehydration and low blood pressure.
  • Lifestyle: Maintain a healthy diet and exercise regime as advised by your doctor. Avoid excessive alcohol intake. Practice good hygiene to prevent genital fungal and urinary tract infections.
  • Do not stop the medication abruptly as it may lead to increased blood sugar levels and potential complications.

• Storage:

  • Store in a cool, dry place below 30°C, away from direct sunlight.
  • Keep out of the sight and reach of children.

GLUCRETA S 10+50 TAB is a medication used to manage type 2 diabetes mellitus. Below are some frequently asked questions about this medicine.

What is GLUCRETA S 10+50 TAB used for?

GLUCRETA S 10+50 TAB is used for the management of type 2 diabetes mellitus in adults, especially when blood sugar levels are not adequately controlled by metformin alone, or in conjunction with diet and exercise. It helps to control high blood sugar levels and can also reduce the risk of serious diabetes complications such as kidney damage, eyesight loss, nerve damage, heart attack, and heart failure.

How does GLUCRETA S 10+50 TAB work?

GLUCRETA S 10+50 TAB is a combination medication containing Dapagliflozin (10mg) and Sitagliptin (50mg). Dapagliflozin works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2), which is responsible for reabsorbing glucose from urine back into the blood. This action causes the removal of excess sugar through the urine, thereby reducing blood sugar levels. Sitagliptin works by increasing the levels of natural substances called incretins, which help to increase insulin release after meals and decrease the amount of sugar the liver produces.

What is the usual dosage for GLUCRETA S 10+50 TAB?

The dosage of GLUCRETA S 10+50 TAB is determined by your doctor based on your medical condition and response to treatment. It is typically taken once daily, with or without food, but it is best to take it consistently at the same time each day for optimal benefits. Do not stop taking the medication without consulting your doctor.

What are the possible side effects of GLUCRETA S 10+50 TAB?

Common side effects of GLUCRETA S 10+50 TAB may include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, headache, flatulence, constipation, and stomach pain. Some individuals might also experience fungal infections in the genital area. It's important to drink plenty of fluids to prevent dehydration. Serious side effects, though rare, can include acute pancreatitis, severe allergic reactions, and diabetic ketoacidosis.

Is GLUCRETA S 10+50 TAB safe during pregnancy or breastfeeding?

There is limited information on the effect of GLUCRETA S 10+50 TAB in pregnant women, and therefore, it should not be used during pregnancy unless considered clearly necessary by a doctor. Similarly, information on whether it passes into human breast milk is not available, so it should not be used in breastfeeding women. Always inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can GLUCRETA S 10+50 TAB be taken with other medications?

GLUCRETA S 10+50 TAB can interact with other medications. It is crucial to inform your doctor about all other medicines, herbal supplements, and vitamins you are currently taking to avoid potential interactions. Particular care should be taken if you are taking medicines for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin, rifampin), HIV/AIDS (e.g., ritonavir), heart failure (e.g., digoxin), or diuretics (e.g., furosemide, hydrochlorothiazide). Taking it with insulin or other anti-diabetic medicines like sulfonylureas may increase the risk of extremely low blood sugar levels (hypoglycemia).

What precautions should be taken while taking GLUCRETA S 10+50 TAB?

Before taking GLUCRETA S 10+50 TAB, inform your doctor if you have kidney or liver problems, heart failure, a history of pancreatitis, gallstones, alcohol dependence, or high triglyceride levels. It is not recommended for individuals with type 1 diabetes or diabetic ketoacidosis. Maintain good hygiene to prevent genital fungal infections and drink plenty of fluids to avoid dehydration. Avoid excessive alcohol consumption as it may increase the risk of side effects like diabetic ketoacidosis. Regular monitoring of blood sugar levels is crucial.

What happens if a dose of GLUCRETA S 10+50 TAB is missed?

If you miss a dose of GLUCRETA S 10+50 TAB, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed dose. If you miss several doses and experience symptoms of high blood sugar (hyperglycemia), contact your doctor.

How should GLUCRETA S 10+50 TAB be stored?

GLUCRETA S 10+50 TAB should be stored in a cool and dry place, away from direct sunlight and out of the reach of children. The typical storage temperature is between 10ºC and 25ºC or below 30ºC.