Arnicor 100 Mg Tablet (10 Tab)

ARNICOR 100 MG TABLET

ARNICOR 100 mg Tablet is a prescription medicine manufactured by Cipla Ltd., primarily used for the management of chronic heart failure in adults. It belongs to a class of medications called Angiotensin Receptor Neprilysin Inhibitors (ARNIs).

Composition Each ARNICOR 100 mg Tablet contains a combination of two active ingredients:

• Sacubitril (49 mg)
• Valsartan (51 mg)

Sacubitril acts as a neprilysin inhibitor, increasing beneficial natriuretic peptides that relax blood vessels and reduce cardiac strain. Valsartan is an angiotensin II receptor blocker (ARB) that blocks hormones which constrict blood vessels, thus lowering blood pressure and reducing the heart's workload.

Uses ARNICOR 100 mg Tablet is prescribed to treat chronic heart failure in adults, specifically those with reduced ejection fraction (NYHA Class II-IV). It helps to:

• Reduce the risk of cardiovascular death and hospitalization for heart failure.
• Improve the heart's ability to pump blood efficiently.
• Relieve symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles.

Dosage and Administration The typical starting dose for ARNICOR is 49/51 mg (equivalent to ARNICOR 100 mg) orally twice daily. The dose may be doubled after 2 to 4 weeks to a target maintenance dose of 97/103 mg (equivalent to ARNICOR 200 mg) twice daily, as tolerated. The tablet should be swallowed whole with a glass of water, with or without food, preferably at the same time each day to maintain consistent medication levels. Do not chew, crush, or break the tablet. Do not stop taking the medication suddenly, as it may worsen the condition.

Side Effects Common side effects may include:

• Low blood pressure (hypotension), which can cause dizziness or light-headedness.
• High potassium levels in the blood (hyperkalemia), potentially leading to muscle weakness or irregular heartbeat.
• Kidney problems or impaired renal function.
• Cough
• Dizziness, headache, and fatigue.
• Nausea and diarrhea.

Serious but less common side effects include angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention.

Precautions

• Allergies: Do not take if allergic to sacubitril, valsartan, or any other ingredients.
• ACE Inhibitors: Do not take ARNICOR 100 mg Tablet with ACE inhibitors. A washout period of at least 36 hours is required when switching between an ACE inhibitor and ARNICOR.
• Pregnancy and Breastfeeding: ARNICOR is not recommended during pregnancy, especially in the last 6 months, as it can harm the unborn baby. It is also not recommended during breastfeeding.
• Liver and Kidney Disease: Use with caution in patients with liver or kidney problems; dose adjustments may be necessary.
• Other Medications: Inform your doctor about all medications, including aliskiren, other blood pressure medications, lithium, and potassium supplements, as interactions can occur.
• Alcohol: Limit alcohol consumption, as it may intensify side effects like dizziness or fatigue.
• Driving: Avoid driving or operating heavy machinery if you experience dizziness.

Storage Store ARNICOR 100 mg Tablet in a cool and dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children. The recommended storage temperature is below 30°C (10°C to 25°C).

ARNICOR 100 MG TABLET by CIPLA LTD. is a prescription medication primarily used to treat chronic heart failure. It contains a combination of two active ingredients: Sacubitril and Valsartan.

Here are some frequently asked questions about ARNICOR 100 MG TABLET:

What is ARNICOR 100 MG TABLET used for?

ARNICOR 100 MG TABLET is indicated for the treatment of chronic heart failure in adults (classified as New York Heart Association Class II-IV) who have a reduced ejection fraction. It helps reduce the risk of cardiovascular death and hospitalisation due to heart failure. This medication also helps manage associated symptoms such as breathlessness, fatigue, tiredness, and swelling in the ankles.

How does ARNICOR 100 MG TABLET work?

ARNICOR 100 MG TABLET is a combination of Sacubitril and Valsartan, which belong to a class of medicines called Angiotensin Receptor Neprilysin Inhibitors (ARNIs). Sacubitril works by inhibiting an enzyme called neprilysin, which increases the levels of beneficial peptides that help relax blood vessels and promote the excretion of sodium and water, reducing the strain on the heart. Valsartan is an angiotensin receptor blocker (ARB) that blocks the action of angiotensin II, a hormone that causes blood vessels to narrow. Together, these two components relax and widen blood vessels, making it easier for the heart to pump blood throughout the body and reducing fluid retention.

What is the usual dosage for ARNICOR 100 MG TABLET?

The typical starting dose for ARNICOR is 49/51 mg (Sacubitril/Valsartan) orally twice daily. Your doctor may double this dose after 2 to 4 weeks to a target maintenance dose of 97/103 mg (Sacubitril/Valsartan) twice daily, depending on how well you tolerate the medication. The tablet should be swallowed whole with a glass of water, and not crushed or chewed. It can be taken with or without food, preferably at the same time each day to maintain consistent medication levels.

What are the possible side effects of ARNICOR 100 MG TABLET?

Common side effects include dizziness, light-headedness (due to low blood pressure), cough, headache, tiredness, nausea, diarrhoea, weakness, increased potassium levels in the blood (hyperkalaemia), and decreased kidney function. In some cases, signs of low red blood cells (anaemia), fainting, or a spinning sensation may occur. A serious but rare side effect is angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention. Most common side effects usually resolve over time, but you should consult your doctor if they persist or worsen.

Is ARNICOR 100 MG TABLET safe during pregnancy or breastfeeding?

No, ARNICOR 100 MG TABLET is not recommended during pregnancy, especially after the first three months, as it can cause serious harm or endanger the developing baby. If you become pregnant while taking this medication, you should stop it and contact your doctor immediately. Similarly, it is not recommended for use by breastfeeding women due to potential risks to the baby.

Can ARNICOR 100 MG TABLET be taken with other medications?

ARNICOR 100 MG TABLET has significant drug interactions and should not be taken with certain medications:

• ACE inhibitors (e.g., enalapril, lisinopril): Concomitant use is contraindicated due to an increased risk of angioedema. A washout period of at least 36 hours is required when switching from an ACE inhibitor to ARNICOR or vice versa.
• Aliskiren: Concomitant use is contraindicated in patients with diabetes or kidney disease.
• Other Angiotensin Receptor Blockers (ARBs): Avoid concomitant use as ARNICOR already contains valsartan.
• Potassium supplements, potassium-sparing diuretics, or salt substitutes containing potassium: These can increase the risk of high potassium levels in the blood.
• Nonsteroidal anti-inflammatory drugs (NSAIDs): Can reduce the blood pressure-lowering effect and worsen kidney function, particularly in elderly or dehydrated patients.
• Lithium: Use with caution.
• Sildenafil: May cause a further decrease in blood pressure.

Always inform your doctor about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking.

What precautions should be taken while on ARNICOR 100 MG TABLET?

It is crucial to inform your doctor if you have kidney or liver problems, as dose adjustments or special monitoring may be necessary; severe liver disease is a contraindication. If you have a history of angioedema, inform your doctor. You should avoid driving or operating heavy machinery if you experience dizziness or tiredness. To manage potential dizziness, rise slowly from a sitting or lying position. Regular monitoring of blood pressure, kidney function, and potassium levels is recommended. Avoid alcohol consumption as it can intensify some side effects like dizziness. It is important not to stop taking the medication suddenly without consulting your doctor.

What happens if a dose of ARNICOR 100 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should ARNICOR 100 MG TABLET be stored?

Store ARNICOR 100 MG TABLET in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. The medication should not be stored above 30°C and should be kept in its original packaging to protect it from moisture.