Monotrate Sr 30 Mg Tablet (10 Tab)

MONOTRATE SR 30 MG TABLET

Monotrate SR 30 mg Tablet is a medication manufactured by Sun Pharma Laboratories Ltd., primarily used for the management and prevention of angina pectoris.

• Name:

  • Brand Name: Monotrate SR 30 mg Tablet
  • Common Name: Isosorbide Mononitrate (extended-release or sustained-release)

• Composition:

  • Active Ingredient: Isosorbide Mononitrate 30 mg.

• Uses: Monotrate SR 30 mg Tablet is prescribed for the following medical conditions:

  • Angina Pectoris: It is used to prevent and treat chronic angina (chest pain) caused by reduced blood flow and oxygen supply to the heart muscle due to narrowed blood vessels. It works by relaxing and widening blood vessels, especially those of the heart, which improves blood flow and reduces the heart's workload. It is not for immediate relief of an acute angina attack.
  • Heart Failure: It may also be used in the management of heart failure by easing the workload on the heart.
  • Hypertension: It can help lower high blood pressure by dilating blood vessels.

• Dosage and Administration:

  • Monotrate SR 30 mg Tablet should be taken exactly as prescribed by your doctor, with or without food, at fixed intervals.
  • The tablet should be swallowed whole, without chewing, crushing, or breaking it.
  • For angina, it is often recommended to be taken once daily, preferably in the morning. If taken twice daily, a gap of at least 7 hours between doses is suggested.
  • Do not exceed the prescribed dose. Do not discontinue the medication abruptly without consulting your doctor, as it can worsen your condition.

• Side Effects:

  • Common Side Effects: Headache (which may subside after a few days of treatment), dizziness, lightheadedness, nausea, flushing (redness of the face or neck), tiredness, and decreased blood pressure (hypotension).
  • Serious Side Effects: Severe hypotension (leading to circulatory collapse), rapid or irregular heartbeat (palpitations, tachycardia), severe throbbing headache, confusion, vision problems, vomiting, stomach pain, trouble breathing, bloody diarrhea, cold or clammy skin, sweating, seizures, and fainting.

• Precautions:

  • Allergies: Do not use if you are allergic to isosorbide mononitrate or any nitrate-containing medicines.
  • Drug Interactions:
    • Erectile Dysfunction Medications: Concomitant use with phosphodiesterase inhibitors (e.g., sildenafil, tadalafil, vardenafil) is contraindicated as it can cause a significant and dangerous drop in blood pressure, leading to unconsciousness.
    • Alcohol: Avoid or limit alcohol consumption as it may increase dizziness, cause flushing, and intensify the effects of low blood pressure.
    • Riociguat: Co-administration with riociguat (a soluble guanylate cyclase inhibitor) can cause severe hypotension.
  • Medical Conditions: Use with caution or avoid in patients with severe anemia, severe hypotension, hypertrophic cardiomyopathy, glaucoma, heart attack, head injury/brain hemorrhage, severe liver or kidney problems, or hypovolemia.
  • Pregnancy and Breastfeeding: Consult your doctor before use if you are pregnant or breastfeeding.
  • Driving and Machinery: This medicine may cause dizziness, sleepiness, or affect vision. Avoid driving or operating heavy machinery until you know how it affects you.
  • Tolerance: Follow the prescribed dosing schedule to avoid developing tolerance to the medication, which can make it less effective.

• Storage:

  • Store in a cool and dry place, below 30°C.
  • Protect from light and moisture. Do not refrigerate.

What is MONOTRATE SR 30 MG TABLET used for?

MONOTRATE SR 30 MG TABLET is primarily used to prevent and treat angina pectoris, which is heart-related chest pain caused by reduced blood flow to the heart muscle. It helps manage chronic stable angina and reduces the frequency of angina attacks. This medicine does not provide immediate relief for an angina attack that has already started. It may also be used in the management of heart failure and coronary artery disease.

How does MONOTRATE SR 30 MG TABLET work?

MONOTRATE SR 30 MG TABLET contains isosorbide mononitrate, which belongs to a class of medicines called nitrates. It works by releasing nitric oxide in the body. This chemical relaxes and widens blood vessels, including the coronary arteries, which improves blood and oxygen supply to the heart. By dilating veins, it reduces the amount of blood returning to the heart (preload) and by dilating arteries, it reduces the resistance the heart pumps against (afterload). This dual action reduces the workload on the heart and decreases its oxygen demand, thereby preventing angina attacks.

What is the usual dosage for MONOTRATE SR 30 MG TABLET?

MONOTRATE SR 30 MG TABLET should be taken exactly as prescribed by your doctor. It is usually taken once daily, preferably in the morning. If a twice-daily dose is recommended, a gap of at least 7 hours should be maintained between doses to prevent the medicine from becoming less effective over time. The tablet should be swallowed whole with a glass of water, without crushing or chewing. It can be taken with or without food. Do not take more than the prescribed dose.

What are the possible side effects of MONOTRATE SR 30 MG TABLET?

Common side effects of MONOTRATE SR 30 MG TABLET include headache, dizziness, lightheadedness, nausea, and flushing (redness of the face or neck). These side effects usually subside with continued treatment. Other possible side effects can include fatigue, decreased blood pressure (hypotension), and rapid heartbeat (palpitations). If any side effects worsen or persist, it is important to consult your doctor. In rare cases, severe decreased blood pressure can occur, leading to symptoms like pale skin, rapid breathing, weak pulse, dizziness, confusion, and anxiety, which require immediate medical attention.

Is MONOTRATE SR 30 MG TABLET safe during pregnancy or breastfeeding?

MONOTRATE SR 30 MG TABLET should be used with caution during pregnancy and breastfeeding. Limited human data is available regarding its safety during pregnancy, and animal studies suggest potential risks. If you are pregnant or planning a pregnancy, consult your doctor to discuss the benefits and risks. It is not well-established if the medication passes into breast milk or affects milk supply, so it's best to consult your doctor before using it while breastfeeding.

Can it be taken with other medications?

It is crucial to inform your doctor about all medicines, herbals, and supplements you are currently taking or plan to take to avoid possible interactions. MONOTRATE SR 30 MG TABLET should not be taken with medicines used for erectile dysfunction, such as sildenafil, tadalafil, or vardenafil, as this combination can cause a significant and dangerous drop in blood pressure, leading to fainting or even a heart attack. Concomitant use with other blood pressure-lowering medicines (e.g., beta-blockers, calcium channel blockers, vasodilators) can also lead to a significant reduction in blood pressure. Riociguat, a soluble guanylate cyclase inhibitor, should also be avoided due to the risk of severe hypotension.

What precautions should be taken?

Avoid consuming alcohol while taking MONOTRATE SR 30 MG TABLET, as it can cause a significant drop in blood pressure and lead to dizziness, tiredness, headache, or blurred vision. This medicine can cause dizziness or sleepiness, so avoid driving or operating heavy machinery until you know how it affects you.

Inform your doctor if you have conditions such as low blood pressure, severe anemia, hypertrophic cardiomyopathy (thickening of heart muscles), glaucoma (increased pressure in the eye), or severe kidney or liver disorders. Do not stop taking the medicine suddenly without consulting your doctor, as it can worsen your condition or increase the risk of an angina attack.

What happens if a dose is missed?

If you miss a dose of MONOTRATE SR 30 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

MONOTRATE SR 30 MG TABLET should be stored below 30°C in its original container. Keep it out of the reach of children and pets. Protect it from light and moisture. Do not refrigerate the medicine.