KETOFLAM-P TAB

KETOFLAM-P TAB is a medication manufactured by Lupin Ltd., used for its pain-relieving and anti-inflammatory properties.

• Name: KETOFLAM-P Tablet

• Composition: KETOFLAM-P Tablet contains a combination of two active ingredients:

  • Flupirtine (100mg)
  • Paracetamol (325mg) Flupirtine is a non-opioid analgesic that works by blocking the transmission of pain signals to the brain, thereby reducing pain perception. Paracetamol acts as an analgesic and antipyretic by inhibiting the release of chemical messengers (prostaglandins) that cause pain and fever.

• Uses: KETOFLAM-P Tablet is primarily used for the management of acute and chronic pain. It is prescribed for various conditions, including:

  • Post-surgical pain
  • Dental pain
  • Pain associated with muscle spasm
  • Cancer pain
  • Neuropathic pain
  • Low back pain
  • Migraine and severe headaches
  • Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis
  • Musculoskeletal pain
  • Ear and throat pain
  • Menstrual pain (dysmenorrhoea)
  • Fever

• Dosage and Administration:

  • KETOFLAM-P Tablet should be taken orally as directed by your doctor.
  • It is generally advised to take the tablet with food to prevent stomach upset.
  • Swallow the tablet whole with water; do not crush, break, or chew it.
  • The dosage and duration of treatment depend on the specific condition and the patient's response. For instance, for back pain, a typical dosage might be 1 tablet, 3 times daily.
  • Do not exceed the recommended dosage or duration.

• Side Effects:

  • Common Side Effects: Nausea, vomiting, abdominal discomfort, diarrhoea, constipation, heartburn, flatulence, dry mouth, headache, drowsiness, dizziness, fatigue, depression, disorientation, shaking (tremors), hallucinations, sleep problems, increased sweating, loss of appetite, restlessness, and nervousness.
  • Serious Side Effects: Stop taking the medicine and consult your physician immediately if you experience severe allergic reactions (swelling of face, lips, tongue, or throat causing difficulty breathing) or signs of liver damage (jaundice, hepatic necrosis, liver failure, abdominal pain, itchy skin, dark-colored urine).

• Precautions:

  • Liver and Kidney Disease: KETOFLAM-P Tablet is not recommended for patients with liver or kidney diseases due to the increased risk of liver damage, especially with the Paracetamol component. Close monitoring of liver function is necessary for patients with liver impairment.
  • Alcohol: Avoid alcohol consumption while taking this medication, as it significantly increases the risk of liver damage and can intensify drowsiness.
  • Pregnancy and Breastfeeding: Not recommended during pregnancy or breastfeeding, as safety is not established and it may pass into breast milk. Consult a doctor before use.
  • Children and Elderly: Not recommended for children and adolescents under 18 years of age. Elderly patients (65 years or above) should use it with caution and may require dosage adjustments.
  • Driving and Operating Machinery: May cause dizziness or drowsiness; therefore, avoid driving or operating heavy machinery until you know how the medicine affects you.
  • Allergies: Do not use if allergic to Flupirtine, Paracetamol, or any other ingredients.
  • Other Conditions: Inform your doctor if you have a history of stomach ulcers, bleeding, high blood pressure, heart problems, hepatic encephalopathy, ataxia, myasthenia gravis, or tinnitus.

• Storage: Store KETOFLAM-P Tablet in a cool and dry place, ideally below 30°C. Keep it away from moisture, direct light, and out of reach of children.

What is Ketoflam-P Tablet used for?

Ketoflam-P Tablet is primarily used for pain relief and to reduce inflammation. It effectively treats various types of acute and chronic pain, including muscle pain, joint pain, post-surgical pain, cancer pain, menstrual pain (dysmenorrhoea), tension headaches, back pain, toothache, and ear and throat pain. It is also prescribed for conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis, and can help reduce fever associated with pain.

How does Ketoflam-P Tablet work?

Ketoflam-P Tablet contains two active ingredients: Flupirtine (100 mg) and Paracetamol (325 mg). Flupirtine acts as an analgesic that blocks the transmission of pain signals to the brain, thereby reducing the perception of pain. Paracetamol functions as both an analgesic (pain reliever) and an antipyretic (fever reducer) by inhibiting the release of certain chemical messengers, such as prostaglandins, which are responsible for causing pain and fever.

What is the usual dosage for Ketoflam-P Tablet?

The dosage of Ketoflam-P Tablet should always be as prescribed by your doctor, as it depends on the specific condition being treated and your response to the medication. It is typically taken orally with a meal to help prevent stomach upset. The tablet should be swallowed whole and not chewed, broken, or crushed. For adults, a common recommendation is one tablet every six to eight hours, with a maximum daily dose of four tablets, but it is crucial not to exceed the dosage advised by your doctor.

What are the possible side effects of Ketoflam-P Tablet?

Common side effects of Ketoflam-P Tablet may include nausea, vomiting, constipation, dry mouth, dizziness, headache, and sleepiness or drowsiness. Other potential side effects include abdominal discomfort, diarrhea, heartburn, flatulence, fatigue, depression, disorientation, shaking (tremors), hallucinations, sleep problems, increased sweating, loss of appetite, restlessness, nervousness, and skin rash. Most of these side effects are temporary; however, if they persist or worsen, you should consult your doctor. This medication, particularly due to its paracetamol component, carries a risk of liver damage, especially with alcohol consumption.

Is Ketoflam-P Tablet safe during pregnancy or breastfeeding?

Pregnancy: Caution is advised when taking Ketoflam-P Tablet during pregnancy, and its safety is not fully established. It is best to consult your doctor before using this medicine if you are pregnant or planning a pregnancy, as they will evaluate the potential benefits against the risks.

Breastfeeding: Ketoflam-P Tablet is generally not recommended during breastfeeding because its components can pass into breast milk. While one source suggests it is "considered safe" with caution, consulting your doctor is strongly advised before taking this medication while breastfeeding.

Can Ketoflam-P Tablet be taken with other medications?

Ketoflam-P Tablet may interact with several other medications. It can reduce the effect of anticonvulsants like phenytoin or carbamazepine. Taking it with some antidepressants (e.g., fluoxetine, sertraline) may increase side effects. Medications that induce liver enzymes, such as rifampicin or phenobarbital, can alter its processing in the body, potentially reducing efficacy. Combining it with other pain relievers may escalate the risk of liver damage due to high paracetamol levels. Additionally, it may interact with sedatives, tranquilizers, anticoagulants (like warfarin and heparin), chloramphenicol, colestyramine, metoclopramide, and domperidone. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using Ketoflam-P Tablet?

Several precautions should be observed:

• Liver/Kidney Disease: Use with caution if you have liver or kidney problems. It is not recommended for severe or active liver disease, and liver function should be closely monitored.
• Alcohol: Avoid consuming alcohol as it increases the risk of liver damage and can intensify side effects like dizziness and drowsiness.
• Driving/Machinery: Do not drive or operate heavy machinery if you experience dizziness or drowsiness.
• Stomach Issues: Take the tablet with food to prevent an upset stomach.
• Allergies: Do not take if you are allergic to any of its ingredients.
• Children and Elderly: It is not recommended for children and adolescents under 18 years of age. Elderly patients (65 years and above) should consult their doctor, as dosage adjustments might be necessary.
• Pre-existing Conditions: Inform your doctor if you have a history of stomach ulcers, bleeding, high blood pressure, heart issues, or chronic malnutrition.

What happens if a dose of Ketoflam-P Tablet is missed?

If you forget to take your Ketoflam-P Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Ketoflam-P Tablet be stored?

Ketoflam-P Tablet should be stored in a cool place, ideally below 30°C. Keep it away from moisture and direct light. Always ensure the medicine is kept out of the reach of children. Use the product before the expiry date printed on the package.