Nervite Tablet

NERVITE TABLET by MACLEODS PHARMACEUTICALS LTD.

Name

Brand Name: Nervite Tablet Common Name: Pregabalin and Nortriptyline (Fixed-dose combination)

Composition

Nervite Tablet contains two active ingredients:

• Pregabalin (typically 75 mg) - an anticonvulsant and neuropathic pain agent.
• Nortriptyline (typically 10 mg) - a tricyclic antidepressant.

Uses

Nervite Tablet is prescribed for the management of various neuropathic pain conditions. These include:

• Neuropathic pain associated with diabetic peripheral neuropathy.
• Postherpetic neuralgia.
• Fibromyalgia.
• Neuropathic pain associated with spinal cord injury.

It works by reducing pain signals from damaged nerves and increasing certain nerve transmitters in the brain to alleviate pain messages.

Dosage and Administration

Take Nervite Tablet orally as directed by your doctor. It can be taken with or without food, preferably at bedtime, to maintain a consistent level of medicine in the blood. Swallow the tablet whole; do not crush or chew it. The dosage and duration of treatment depend on the medical condition and individual response to the medication. Do not exceed the prescribed dosage.

Side Effects

Common side effects may include:

• Dizziness.
• Drowsiness/Sleepiness.
• Dry mouth.
• Blurred vision.
• Weight gain.
• Constipation.
• Nausea.
• Peripheral oedema (swelling of lower legs and hands).
• Difficulty in urination.
• Weakness or confusion.

Consult your doctor if these side effects persist or worsen.

Precautions

• Alcohol: Avoid consuming alcohol as it may increase the risk of dizziness and sleepiness.
• Pregnancy and Breastfeeding: Not recommended during pregnancy due to limited safety information; consult a doctor. Not recommended during breastfeeding as ingredients may pass into breast milk; consult a doctor.
• Children: Not recommended for use in children as safety and effectiveness have not been established.
• Driving and Operating Machinery: May cause drowsiness and dizziness; avoid driving or operating machinery until you know how the medicine affects you.
• Medical Conditions: Inform your doctor if you have heart problems, bipolar syndrome, severe liver disease, kidney problems, diabetes, or a history of suicidal thoughts.
• Drug Interactions: Inform your doctor about all medicines you are taking, especially MAO inhibitors (should not be taken within 14 days of Nervite Tablet) and cough-cold medicines containing adrenaline-like drugs.
• Discontinuation: Do not stop taking Nervite Tablet suddenly without consulting your doctor, as it may lead to withdrawal symptoms.

Storage

Store Nervite Tablet at room temperature (20-25°C), protected from moisture and light. Keep it in its original packaging, in a cool, dry place, out of reach of children. Dispose of unused medications safely.

What is Nervite Tablet used for?

Nervite Tablet is a combination medicine primarily used for the treatment of neuropathic pain. This type of pain is caused by damage to nerves, often associated with conditions like diabetic peripheral neuropathy, postherpetic neuralgia (pain after shingles), and spinal cord injury. It helps reduce chronic pain and its associated symptoms, such as mood changes, sleep problems, and tiredness.

How does Nervite Tablet work?

Nervite Tablet contains two active ingredients: Pregabalin and Nortriptyline. Pregabalin works by reducing the release of certain chemical messengers (neurotransmitters) in the brain that are responsible for transmitting pain signals. Nortriptyline, a tricyclic antidepressant, increases the levels of other chemical messengers, such as serotonin and noradrenaline, in the brain, which helps to reduce the pain messages reaching the brain and regulate mood. Together, these components work synergistically to alleviate nerve pain.

What is the usual dosage for Nervite Tablet?

Nervite Tablet should be taken exactly as prescribed by your doctor. It is typically taken once daily, with or without food, and preferably at the same time each day, often at bedtime. Do not exceed the prescribed dosage, and never stop taking the medication abruptly, as your doctor will gradually decrease the dose before discontinuing it.

What are the possible side effects of Nervite Tablet?

Common side effects of Nervite Tablet can include dizziness, sleepiness, dry mouth, constipation, weight gain, blurred vision, headache, aggression, and nasal congestion. Some individuals may also experience nausea, tiredness, lack of sleep (insomnia), loss of coordination, difficulty in urination, or swelling in the hands or feet. It's important to inform your doctor if any side effects persist or worsen, and to report any unusual changes in mood, behavior, new or worsening depression, or suicidal thoughts.

Is Nervite Tablet safe during pregnancy or breastfeeding?

Nervite Tablet is generally not recommended for use during pregnancy due to limited information on its safety. If you are pregnant, planning to become pregnant, or discover you are pregnant while taking this medicine, you should inform your doctor immediately. Similarly, it is advised not to breastfeed while undergoing treatment with Nervite Tablet, as it may pass into breast milk and potentially harm the newborn baby. Your doctor will assess the risks and benefits to determine the best course of action.

Can Nervite Tablet be taken with other medications?

It is crucial to inform your doctor about all the medications, supplements, or herbal products you are currently taking or plan to take to avoid potential interactions. Nervite Tablet can interact with various medicines, including certain pain relievers (especially opioid analgesics), other antidepressants (such as MAO inhibitors, which are strictly contraindicated), medicines for diabetes (as it may alter blood sugar levels), corticosteroids, blood thinners, antibiotics, muscle relaxants, and medications for mental disorders. Alcohol consumption should be avoided as it can increase side effects like dizziness and drowsiness.

What precautions should be taken while taking Nervite Tablet?

Due to potential side effects like dizziness, drowsiness, and blurred vision, you should avoid driving or operating heavy machinery until you understand how this medicine affects you. Inform your doctor if you have any pre-existing medical conditions such as heart disease, high blood pressure, diabetes, liver or kidney problems, thyroid disorders, glaucoma, or a history of seizures. Do not stop taking Nervite Tablet suddenly, as this can lead to withdrawal symptoms. Elderly patients should use this medication with caution, as they may be more sensitive to its side effects.

What happens if a dose of Nervite Tablet is missed?

If you miss a dose of Nervite Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this may increase the risk of side effects.

How should Nervite Tablet be stored?

Nervite Tablet should be stored in a cool, dry place, away from direct light and moisture. Keep it out of the reach and sight of children and pets.### What is Nervite Tablet used for? Nervite Tablet is a combination medicine primarily used for the treatment of neuropathic pain. This type of pain is caused by damage to nerves, often associated with conditions like diabetic peripheral neuropathy, postherpetic neuralgia (pain after shingles), and spinal cord injury. It helps reduce chronic pain and its associated symptoms, such as mood changes, sleep problems, and tiredness.

How does Nervite Tablet work?

Nervite Tablet contains two active ingredients: Pregabalin and Nortriptyline. Pregabalin works by reducing the release of certain chemical messengers (neurotransmitters) in the brain that are responsible for transmitting pain signals. Nortriptyline, a tricyclic antidepressant, increases the levels of other chemical messengers, such as serotonin and noradrenaline, in the brain, which helps to reduce the pain messages reaching the brain and regulate mood. Together, these components work synergistically to alleviate nerve pain.

What is the usual dosage for Nervite Tablet?

Nervite Tablet should be taken exactly as prescribed by your doctor. It is typically taken once daily, with or without food, and preferably at the same time each day, often at bedtime. Do not exceed the prescribed dosage, and never stop taking the medication abruptly, as your doctor will gradually decrease the dose before discontinuing it.

What are the possible side effects of Nervite Tablet?

Common side effects of Nervite Tablet can include dizziness, sleepiness, dry mouth, constipation, weight gain, blurred vision, headache, aggression, and nasal congestion. Some individuals may also experience nausea, tiredness, lack of sleep (insomnia), loss of coordination, difficulty in urination, or swelling in the hands or feet. It's important to inform your doctor if any side effects persist or worsen, and to report any unusual changes in mood, behavior, new or worsening depression, or suicidal thoughts.

Is Nervite Tablet safe during pregnancy or breastfeeding?

Nervite Tablet is generally not recommended for use during pregnancy due to limited information on its safety. If you are pregnant, planning to become pregnant, or discover you are pregnant while taking this medicine, you should inform your doctor immediately. Similarly, it is advised not to breastfeed while undergoing treatment with Nervite Tablet, as it may pass into breast milk and potentially harm the newborn baby. Your doctor will assess the risks and benefits to determine the best course of action.

Can Nervite Tablet be taken with other medications?

It is crucial to inform your doctor about all the medications, supplements, or herbal products you are currently taking or plan to take to avoid potential interactions. Nervite Tablet can interact with various medicines, including certain pain relievers (especially opioid analgesics), other antidepressants (such as MAO inhibitors, which are strictly contraindicated), medicines for diabetes (as it may alter blood sugar levels), corticosteroids, blood thinners, antibiotics, muscle relaxants, and medications for mental disorders. Alcohol consumption should be avoided as it can increase side effects like dizziness and drowsiness.

What precautions should be taken while taking Nervite Tablet?

Due to potential side effects like dizziness, drowsiness, and blurred vision, you should avoid driving or operating heavy machinery until you understand how this medicine affects you. Inform your doctor if you have any pre-existing medical conditions such as heart disease, high blood pressure, diabetes, liver or kidney problems, thyroid disorders, glaucoma, or a history of seizures. Do not stop taking Nervite Tablet suddenly, as this can lead to withdrawal symptoms. Elderly patients should use this medication with caution, as they may be more sensitive to its side effects.

What happens if a dose of Nervite Tablet is missed?

If you miss a dose of Nervite Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this may increase the risk of side effects.

How should Nervite Tablet be stored?

Nervite Tablet should be stored in a cool, dry place, away from direct light and moisture. Keep it out of the reach and sight of children and pets.