Glyree 1 Mg Tablet (10 Tab)

GLYREE 1 MG TABLET

GLYREE 1 MG TABLET is an oral anti-diabetic medication manufactured by IPCA LABORATORIES LTD., primarily used for the management of Type 2 Diabetes Mellitus.

Composition

Active Ingredient: Glimepiride 1 mg.

Uses

GLYREE 1 MG TABLET is prescribed for adults with Type 2 Diabetes Mellitus, especially when diet and exercise alone are insufficient to control blood sugar levels. It works by stimulating the pancreas to produce more insulin and by increasing the sensitivity of body tissues to insulin, thereby lowering high blood glucose levels. This medication can be used alone or in combination with other anti-diabetic drugs, including insulin, to achieve better glycemic control and reduce the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, and heart disease.

Dosage and Administration

The dosage of GLYREE 1 MG TABLET is individualized by a doctor based on the patient's condition and response to treatment. It should be taken once daily, preferably just before or with breakfast or the first main meal of the day. The tablet should be swallowed whole with water and not cut, broken, or chewed. It is crucial not to take this medicine on an empty stomach. The usual starting dose is 1 mg or 2 mg once daily, with a typical maintenance dose ranging from 1-4 mg once daily. The maximum recommended daily dose is 8 mg. Do not stop taking the medicine without consulting your doctor, even if your blood sugar levels are controlled.

Side Effects

Common side effects include:

• Hypoglycemia (low blood sugar), which can manifest as increased hunger, sweating, shakiness, weakness, rapid heartbeat, dizziness, headache, blurred vision, anxiety, irritability, and confusion.
• Nausea
• Headache
• Dizziness
• Weight gain
• Upper respiratory tract infection
• Flu-like symptoms

Serious but less common side effects may include haemolytic anaemia and allergic skin reactions.

Precautions

• Hypoglycemia: There is a high risk of low blood sugar, especially when used with other anti-diabetic medicines, alcohol, or if meals are delayed or missed.
• Alcohol Consumption: Avoid excessive alcohol intake as it can significantly increase the risk of low blood sugar and lactic acidosis.
• Pregnancy and Breastfeeding: Not recommended during pregnancy unless clearly necessary, as it may harm the unborn baby. Use with caution during breastfeeding as the medicine may pass into breast milk, potentially causing low blood sugar in the infant. Consult your doctor.
• Kidney and Liver Disease: Use with caution. Dose adjustments may be necessary. It is not recommended in severe kidney or liver disease due to an increased risk of severe hypoglycemia.
• Contraindications: Do not use if you have Type 1 Diabetes Mellitus, diabetic ketoacidosis, or are allergic to glimepiride, sulfonylureas, or sulfonamides. Also, avoid if you have G6PD-deficiency.
• Driving and Machinery: Blood sugar fluctuations (hypoglycemia or hyperglycemia) can affect alertness. Exercise caution when driving or operating machinery until you know how the medicine affects you.
• Drug Interactions: Inform your doctor about all medications you are taking, as GLYREE 1 MG TABLET can interact with various drugs including insulin, ACE inhibitors, corticosteroids, thiazides, thyroid hormones, and certain antifungals, potentially altering its effects or increasing side effects.
• Photosensitivity: This medicine may make your skin more sensitive to sunlight. It is advisable to use sunscreen or wear protective clothing when outdoors.

Storage

Store GLYREE 1 MG TABLET below 30°C, ideally between 20°C to 25°C, in a cool, dry place. Protect from direct sunlight and moisture. Ensure the lid is tightly closed after use to prevent exposure to air and moisture. Keep out of the sight and reach of children.

GLYREE 1 MG TABLET contains Glimepiride, an oral anti-diabetic medication. It is primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus.

What is GLYREE 1 MG TABLET used for?

GLYREE 1 MG TABLET is used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet, physical exercise, and weight reduction alone are insufficient. By managing blood sugar, it helps prevent serious complications of diabetes, such as kidney damage, blindness, nerve problems, and heart disease.

How does GLYREE 1 MG TABLET work?

GLYREE 1 MG TABLET belongs to a class of medicines called sulfonylureas. It works by stimulating the beta cells in the pancreas to release more insulin. Additionally, it increases the sensitivity of your body's peripheral tissues to insulin, which helps the body use insulin more effectively to lower blood sugar levels.

What is the usual dosage for GLYREE 1 MG TABLET?

The recommended starting dose for GLYREE 1 MG TABLET is typically 1 mg or 2 mg once daily, taken with breakfast or the first main meal of the day. For individuals at a higher risk of low blood sugar, such as the elderly or patients with kidney impairment, a starting dose of 1 mg once daily may be given. The usual maintenance dose ranges from 1–4 mg once daily, with a maximum recommended dose of 8 mg once daily. Dosage adjustments are made by your doctor based on your blood glucose levels, usually not increasing by more than 2 mg at 1- to 2-week intervals. It is important to swallow the tablet whole with water and not to cut, break, or chew it.

What are the possible side effects of GLYREE 1 MG TABLET?

Common side effects include low blood sugar levels (hypoglycemia), nausea, headache, weakness, dizziness, and weight gain. Symptoms of low blood sugar can include sweating, dizziness, headache, shaking, increased hunger, rapid heartbeat, blurry vision, confusion, or anxiety. You should always carry a fast-acting source of glucose, like sugary food or fruit juice, to manage these symptoms.

Is GLYREE 1 MG TABLET safe during pregnancy or breastfeeding?

GLYREE 1 MG TABLET is generally not recommended during pregnancy due to limited information on its safety and potential harm to the unborn baby. Insulin and metformin are often preferred for managing diabetes during pregnancy. If you are pregnant or planning to become pregnant, consult your doctor, as your treatment may need to be reviewed.

It is also not usually recommended while breastfeeding, as it may pass into breast milk and could potentially lower the baby's blood sugar level. An alternative medication may be preferred, especially for newborns or premature infants.

Can GLYREE 1 MG TABLET be taken with other medications?

GLYREE 1 MG TABLET can be used alone or in combination with other anti-diabetic medications like insulin or metformin. However, it can interact with numerous other medications. Some drugs, such as certain antibiotics (e.g., quinolones, chloramphenicol, clarithromycin), antifungals (e.g., fluconazole), ACE inhibitors, salicylates (like aspirin), and certain antidepressants, can increase the blood sugar-lowering effect of Glimepiride, potentially leading to hypoglycemia. Conversely, medications like thiazide diuretics, steroids (e.g., prednisone), thyroid hormones, and oral contraceptives can decrease its effect, causing higher blood sugar.

It is crucial to inform your doctor about all the medicines, supplements, and herbal remedies you are currently taking before starting GLYREE 1 MG TABLET to avoid potential interactions.

What precautions should be taken while taking GLYREE 1 MG TABLET?

Avoid taking GLYREE 1 MG TABLET if you have an allergy to glimepiride, other sulfonylureas, or sulfonamides, or if you have type 1 diabetes mellitus or diabetic ketoacidosis. Exercise caution if you have severe kidney or liver disease, heart disease, thyroid disease, or certain hormonal conditions. Regular monitoring of blood sugar levels is essential, and your doctor may also recommend blood tests to check blood cell counts and liver function.

It is advised to avoid alcohol consumption while on this medication, as it can increase the risk of low blood sugar and, in some cases, lactic acidosis. Be cautious while driving or operating machinery until you understand how the medication affects you, due to the risk of hypoglycemia. Do not stop taking GLYREE 1 MG TABLET without consulting your doctor, even if you feel well, as this could lead to uncontrolled blood sugar levels and diabetes complications.

What happens if a dose of GLYREE 1 MG TABLET is missed?

If you miss a dose of GLYREE 1 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of low blood sugar. If you frequently miss doses or have concerns, contact your doctor.

How should GLYREE 1 MG TABLET be stored?

GLYREE 1 MG TABLET should be stored in its original packaging at room temperature, ideally below 30°C. Keep the tablets in a dry place, away from excess heat and direct sunlight, and ensure the lid is tightly closed to prevent exposure to air and moisture. Always keep this medicine out of the reach of children and pets and ensure it is used before its expiry date.