Cabliz 0.50mg Tab

CABLIZ 0.50MG TAB

Name:

• Brand Name: Cabliz 0.50mg Tablet
• Common Name: Cabergoline

Composition:

• Active Ingredient: Cabergoline 0.5 mg

Uses: CABLIZ 0.50MG TAB is a dopamine agonist primarily used to treat conditions associated with high levels of prolactin hormone (hyperprolactinemia) in the body. This includes:

• Management of infertility and menstrual problems caused by elevated prolactin levels.
• Treatment of abnormal breast milk production (galactorrhea).
• Addressing prolactin-secreting tumors.
• Stopping breast milk production (lactation) in cases of stillbirth, abortion, or miscarriage.

Dosage and Administration: CABLIZ 0.50MG TAB should be taken orally as advised by a healthcare professional. It can be taken with or without food, but it is often recommended to take it with or after food to mitigate side effects like nausea. It is crucial to take the medicine at the same time to ensure consistent benefits. The tablet should be swallowed whole with water; do not chew, crush, or break it. Dosage and frequency depend on the condition being treated and the patient's response, typically administered once or twice a week. Do not discontinue the medication without consulting a doctor.

Side Effects:

• Common Side Effects: Nausea, headache, dizziness, fatigue, depression, low blood pressure (postural hypotension), constipation, abdominal pain, breast pain, sleepiness, nervousness, acne, itching, vertigo, weakness, and paresthesia (tingling or pricking sensation).
• Serious Side Effects (Rare): Abnormal thoughts, heart valve disorders (cardiac valvulopathy), inflammation of the heart (pericarditis), fluid leakage in the pericardium, pulmonary fibrosis (scarring of lungs, heart, or heart valves). Symptoms may include difficulty breathing, chest pain, back pain, pelvic pain, or swollen legs.

Precautions:

• Pregnancy and Breastfeeding: CABLIZ 0.50MG TAB is generally considered unsafe during pregnancy due to definite evidence of risk to the developing baby. It is contraindicated during breastfeeding as it suppresses milk production. Consult a doctor if pregnant, planning pregnancy, or breastfeeding.
• Medical Conditions: Inform your doctor if you have severe liver disease, stiff and inflamed heart valves, uncontrolled high blood pressure, heart disease, kidney problems, Raynaud's syndrome, stomach ulcers, gastrointestinal bleeding, or a history of mental illness.
• Alcohol: Avoid consuming alcohol as it may worsen side effects such as dizziness and drowsiness.
• Driving and Machinery: This medicine can cause dizziness and sleepiness, affecting vision and alertness. Avoid driving or operating heavy machinery until you understand how the medication affects you.
• Blood Pressure: Dizziness due to low blood pressure may occur, especially during the initial days of treatment; rise slowly from sitting or lying positions. Regular blood pressure monitoring may be advised.
• Drug Interactions: Macrolide antibiotics (e.g., erythromycin, clarithromycin) may increase cabergoline levels. Concurrent use with antihypertensives may cause an additive hypotensive effect. Avoid concurrent use with ergot alkaloids (e.g., dihydroergotamine) due to the risk of ergotism.
• Children: Not recommended for use in children under 16 years of age.

Storage: Store CABLIZ 0.50MG TAB in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it below 25°C or 30°C and out of reach of children and pets.

What is CABLIZ 0.50MG TAB used for?

CABLIZ 0.50MG TAB, which contains the active ingredient cabergoline, is primarily used to treat conditions caused by high levels of the hormone prolactin in the body, a condition known as hyperprolactinemia. This can lead to symptoms such as irregular periods, infertility, unwanted breast milk production (galactorrhea), and erectile dysfunction in men. It is also used to inhibit or suppress physiological lactation (breast milk production) soon after childbirth, stillbirth, abortion, or miscarriage. Additionally, it can help shrink prolactin-secreting tumors of the pituitary gland (prolactinomas).

How does CABLIZ 0.50MG TAB work?

CABLIZ 0.50MG TAB works by mimicking the action of dopamine, a natural substance in the brain. It is classified as a dopamine receptor agonist, specifically targeting D2 receptors. By stimulating these receptors, cabergoline inhibits the pituitary gland from releasing prolactin, thereby reducing prolactin levels in the blood.

What is the usual dosage for CABLIZ 0.50MG TAB?

The dosage of CABLIZ 0.50MG TAB varies depending on the condition being treated. For high prolactin levels, the typical starting dose is 0.25 mg twice a week. Your doctor may gradually increase this dose by 0.25 mg every four weeks until optimal prolactin levels are achieved, usually up to a maximum of 1 mg twice weekly, although higher doses might be used in exceptional cases. To inhibit lactation immediately after delivery, a single dose of 1 mg (two 0.5 mg tablets) is often given. For suppressing established lactation, the recommended dose is 0.25 mg (half of a 0.5 mg tablet) every 12 hours for two days. CABLIZ can be taken with or without food; taking it with food may help reduce stomach upset.

What are the possible side effects of CABLIZ 0.50MG TAB?

Common side effects include nausea, headache, dizziness, constipation, fatigue, vomiting, heartburn, breast pain, and painful menstrual periods. More serious side effects, which should be reported to your doctor immediately, include allergic reactions (skin rash, hives, swelling), dry cough, shortness of breath, symptoms of heart failure (such as swelling of ankles, sudden weight gain), heart valve disease, kidney injury, low blood pressure (especially when standing up quickly), and unusual or compulsive behaviors (e.g., gambling, increased sexual urges). Dizziness and lightheadedness can occur, so it's advised to get up slowly from sitting or lying positions.

Is CABLIZ 0.50MG TAB safe during pregnancy or breastfeeding?

Pregnancy: Cabergoline is generally not recommended during pregnancy, although it is classified as FDA pregnancy category B (meaning animal studies haven't shown harm, but human studies are insufficient). Most healthcare providers advise discontinuing the medication once pregnancy is confirmed, especially for microprolactinomas. However, in cases of large macroprolactinomas, a doctor might recommend continuing treatment. It is crucial to use non-hormonal contraception if you wish to avoid pregnancy while taking this medicine.

Breastfeeding: Cabergoline is typically not used during breastfeeding as it works by suppressing milk production. It is, in fact, used to stop breast milk production in specific circumstances.

Can CABLIZ 0.50MG TAB be taken with other medications?

Yes, CABLIZ 0.50MG TAB can interact with other medications. It should generally be avoided with dopamine antagonists such as certain antipsychotics (e.g., haloperidol, chlorpromazine, risperidone, olanzapine, quetiapine) and metoclopramide, as these can reduce its effectiveness. Caution is advised when taken with blood pressure medications, as cabergoline can lower blood pressure. Other ergot alkaloids (like bromocriptine) should be avoided due to potential for increased toxicity. Macrolide antibiotics (e.g., erythromycin, clarithromycin, azithromycin) may increase cabergoline levels, potentially increasing the risk of side effects. Always inform your doctor about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking.

What precautions should be taken while taking CABLIZ 0.50MG TAB?

Before starting CABLIZ, inform your doctor about any existing medical conditions, especially heart disease (including heart valve problems), uncontrolled high blood pressure, fibrotic conditions, or liver disease. Regular monitoring, including blood tests to check prolactin levels, blood pressure measurements, and heart check-ups, may be required during treatment. Due to potential dizziness or drowsiness, avoid driving or operating heavy machinery until you understand how the medication affects you. It's important to report any new or worsening unusual urges or compulsive behaviors, such as increased gambling or sexual urges, to your healthcare provider. Do not stop taking CABLIZ without consulting your doctor.

How should CABLIZ 0.50MG TAB be stored?

CABLIZ 0.50MG TAB should be stored at room temperature, typically between 20-25°C (68-77°F). Keep the medication in its original container, away from heat, moisture, and direct light. It is essential to keep it out of the reach of children and pets, and avoid storing it in damp areas like bathrooms.