Eglucent Mix25 Cartridge

EGLUCENT MIX25 CARTRIDGE by LUPIN LTD

Name

• Brand Name: EGLUCENT MIX25 CARTRIDGE, Eglucent Mix 25
• Common Name: Biphasic Insulin Lispro

Composition

EGLUCENT MIX25 CARTRIDGE contains a pre-mixed combination of two insulin preparations:

• Active Ingredients: Insulin Lispro (25%) and Insulin Lispro Protamine (75%). Insulin Lispro is a fast-acting insulin analog, while Insulin Lispro Protamine provides a prolonged duration of action.

Uses

EGLUCENT MIX25 CARTRIDGE is prescribed for the treatment of:

• Diabetes Mellitus Type 1 and Type 2. It helps improve glycemic control by facilitating glucose absorption into cells and reducing sugar production in the liver.

Dosage and Administration

• Administer subcutaneously into the fatty tissue of the abdomen, thighs, upper arm, or buttocks.
• It should be injected 10-15 minutes prior to, or within 20 minutes of, beginning a meal.
• Rotate injection sites regularly to prevent skin damage like lipodystrophy.
• Before use, roll the cartridge between your hands until the liquid is uniformly white and cloudy; avoid vigorous shaking to prevent frothing.
• Do not inject directly into a vein or muscle. Do not mix with other insulins.

Side Effects

Common Side Effects:

• Hypoglycemia (low blood glucose level), which can manifest as sweating, anxiety, rapid heartbeat, headache, intense hunger, restlessness, dizziness, or irritability.
• Injection site reactions such as pain, redness, itching, swelling, or thickening of the skin (lipodystrophy).
• Weight gain.
• Rash.
• Edema (swelling of body parts).

Serious Side Effects:

• Severe allergic reactions (generalized skin rash with itching, sweating, swelling of layers under the skin, breathing difficulties, palpitation, vomiting, stomach upset, reduction in blood pressure, and fainting/loss of consciousness).

Precautions

• Hypoglycemia: Do not use if you have low blood sugar levels. Always carry a fast-acting source of sugar.
• Organ Impairment: Use with caution in individuals with kidney, liver, or heart problems. Dosage adjustment and close monitoring of blood sugar levels may be necessary.
• Pregnancy and Breastfeeding: Generally considered safe, but insulin needs may change during pregnancy. Consult your doctor for individualized advice and dosage adjustments.
• Alcohol Consumption: Limit or avoid alcohol as it can affect blood sugar control and increase the risk of hypoglycemia.
• Driving and Operating Machines: Your ability to drive or operate machinery may be impaired due to fluctuations in blood sugar levels. Exercise caution.
• Inform your doctor about any hormonal problems, sudden changes to your diet, or intense exercise, as these may require dose adjustments.
• Do not discontinue treatment without consulting your doctor.

Storage

• Unopened Cartridges: Store in a refrigerator between 2°C to 8°C. Do not freeze.
• In-use or Spare Cartridges: Can be kept at room temperature (below 25°C or 30°C depending on specific instructions) for a limited period (e.g., 28 days, though specific duration not consistently provided for Eglucent Mix 25 in search results, standard for insulin is often 28 days).
• Protect from light by storing in the outer carton.
• Keep out of reach of children.

EGLUCENT MIX25 CARTRIDGE by LUPIN LTD is an injectable medication primarily used to manage blood sugar levels in individuals with diabetes. Below are frequently asked questions about this medicine.

1. What is EGLUCENT MIX25 CARTRIDGE used for?

EGLUCENT MIX25 CARTRIDGE is used to improve glycemic control in patients with both Type 1 and Type 2 Diabetes Mellitus. It helps in managing high blood sugar levels by aiding the body in utilizing circulating glucose.

2. How does EGLUCENT MIX25 CARTRIDGE work?

This medicine contains Biphasic Insulin Lispro, which is a pre-mixed combination of Insulin Lispro (a rapid-acting insulin) and Insulin Lispro Protamine (an intermediate-acting insulin). The Insulin Lispro component quickly lowers blood sugar after meals, while the Insulin Lispro Protamine provides a more prolonged and sustained effect. It works by stimulating the uptake of glucose by cells (especially muscle and fat cells) and by reducing glucose production in the liver.

3. What is the usual dosage and administration?

The dosage of EGLUCENT MIX25 CARTRIDGE should always be as prescribed by your doctor. It is typically injected subcutaneously (under the skin) into areas like the abdomen, thigh, or upper arm. It should be administered at least 10-15 minutes before a meal or within 20 minutes of starting a meal. Your doctor or nurse will provide instructions on the correct injection technique.

4. What are the possible side effects of EGLUCENT MIX25 CARTRIDGE?

Common side effects include hypoglycemia (low blood sugar), and reactions at the injection site such as pain, redness, itching, swelling, or the formation of lumps or pits under the skin (lipodystrophy). Other possible side effects include weight gain and oedema (swelling). Severe allergic reactions are rare but require immediate medical attention.

5. Is EGLUCENT MIX25 CARTRIDGE safe during pregnancy or breastfeeding?

EGLUCENT MIX25 CARTRIDGE can be used during pregnancy if prescribed by a physician, though close monitoring and potential dosage adjustments may be necessary as insulin needs can change. For breastfeeding women, it should be used with caution, and it is important to consult your doctor for advice on insulin dosage and blood sugar monitoring.

6. Can EGLUCENT MIX25 CARTRIDGE be taken with other medications?

It is important to inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, as interactions can occur. Some medications (e.g., other diabetes medicines, fluoxetine, salicylates, ramipril, lisinopril, beta-blockers) can increase the risk of low blood sugar, while others (e.g., oral contraceptives, thiazides, steroids, thyroxine, octreotide, lanreotide) can increase blood sugar levels. EGLUCENT MIX25 CARTRIDGE should not be mixed with other types of insulin.

7. What precautions should be taken while using EGLUCENT MIX25 CARTRIDGE?

You should regularly monitor your blood sugar levels and be aware of the symptoms of low blood sugar (hypoglycemia). Always carry a fast-acting source of sugar, such as candy or fruit juice, to treat hypoglycemia quickly. Limit or avoid alcohol consumption as it can interfere with insulin's action and affect blood sugar control. Rotate your injection sites to prevent skin damage. Inform your doctor if you have liver, kidney, or heart problems, hormonal issues, or are making significant changes to your diet or exercise routine. Do not stop taking the medicine without consulting your doctor. Also, avoid driving or operating heavy machinery if you experience symptoms of low or high blood sugar, such as dizziness or visual disturbances. Before injection, roll the cartridge between your hands until the liquid is uniformly cloudy and free of particles, and prime your pen as instructed.

8. What happens if a dose of EGLUCENT MIX25 CARTRIDGE is missed?

Missing a dose can lead to elevated blood sugar levels (hyperglycemia). If you remember shortly after a meal, inject the missed dose immediately. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to compensate for a missed one, as this can cause a dangerous drop in blood glucose.

9. How should EGLUCENT MIX25 CARTRIDGE be stored?

Unopened cartridges of EGLUCENT MIX25 CARTRIDGE should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F). It is crucial not to freeze the medicine. Protect it from light by keeping it in its outer carton. Once in use or carried as a spare, the cartridge can typically be stored at room temperature, usually for up to 4 weeks (28 days).