Vildamac Trio 500 Tab

VILDAMAC TRIO 500 Tablet

Name

• Brand Name: VILDAMAC TRIO 500 Tablet
• Manufacturer: MACLEODS PHARMACEUTICALS LTD

Composition

VILDAMAC TRIO 500 Tablet is a combination medication containing three active antidiabetic agents:

• Metformin: 500 mg (Biguanide)
• Vildagliptin: 100 mg (Dipeptidyl Peptidase-4 inhibitor)
• Dapagliflozin: 10 mg (Sodium-glucose cotransporter-2 inhibitor, SGLT2)

Uses

VILDAMAC TRIO 500 Tablet is primarily used for the management of Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels when diet and exercise alone are insufficient. The combination of these agents works to improve insulin sensitivity, reduce glucose production by the liver, increase insulin release from the pancreas, and enhance glucose excretion through urine. This comprehensive action helps lower both fasting and post-meal blood sugar levels, reducing the risk of diabetes complications such as kidney damage, eye damage, nerve problems, and cardiovascular diseases.

Dosage and Administration

This medicine should be taken in the dose and duration advised by your doctor. It is generally recommended to take VILDAMAC TRIO 500 Tablet with food to minimize gastrointestinal side effects. The tablet should be swallowed whole and not chewed, crushed, or broken. Do not stop taking the medicine abruptly, as this can lead to increased blood sugar levels and serious complications.

Side Effects

Common side effects of VILDAMAC TRIO 500 Tablet may include:

• Vomiting
• Nausea
• Abdominal pain
• Headache
• Frequent urination
• Allergic reactions
• Vaginal yeast infection
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Urinary tract infection (UTI)
• Diarrhea
• Hypoglycemia (low blood sugar), especially when taken with other antidiabetic medicines or alcohol, or due to delayed/skipped meals

If these side effects persist or worsen, or if you experience severe symptoms, consult your doctor.

Precautions

• Allergies: Avoid if allergic to metformin, dapagliflozin, vildagliptin, or any other components of the tablet.
• Pregnancy and Breastfeeding: It is unknown whether it is safe for use during pregnancy, and it is probably unsafe during breastfeeding, as components may pass into breast milk. Consult your doctor if pregnant or breastfeeding.
• Children: Not recommended for use in children below 18 years of age.
• Alcohol: Limit alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
• Medical Conditions: Inform your doctor about any history of liver or kidney disease, heart problems, hypertension, urinary tract infections, or pancreatitis. Use with caution in patients with kidney problems, as it can increase the risk of lactic acidosis if kidney function is impaired.
• Driving: VILDAMAC TRIO 500 may cause dizziness or drowsiness, which could impair your ability to drive or operate machinery. Exercise caution if experiencing these effects.
• Diet: This medicine is part of a treatment program that includes a healthy diet, regular exercise, and weight reduction. Avoid high-carbohydrate or high-sugar meals. Maintain good hygiene to prevent fungal infections in the genital area.

Storage

Store in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. Store at room temperature, ideally below 30ºC.

What is VILDAMAC TRIO 500 TAB used for?

VILDAMAC TRIO 500 TAB is a combination medication primarily used to manage high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is used alongside diet and exercise to improve blood sugar control. This medicine also helps reduce the risk of serious complications associated with diabetes, such as kidney damage, eye damage, nerve problems, and cardiovascular diseases.

How does VILDAMAC TRIO 500 TAB work?

VILDAMAC TRIO 500 TAB combines three active ingredients: Dapagliflozin, Vildagliptin, and Metformin.

• Dapagliflozin works by increasing the excretion of glucose from your body through urine.
• Vildagliptin enhances glucose-mediated insulin secretion, leading to reduced fasting and post-meal blood sugar concentrations. It also signals the liver to stop producing sugar when there's too much in the blood.
• Metformin decreases the amount of glucose absorbed from food in the intestines and reduces glucose production by the liver. It also improves the body's sensitivity to insulin.

What is the usual dosage for VILDAMAC TRIO 500 TAB?

You should take VILDAMAC TRIO 500 TAB exactly as prescribed by your doctor. It is usually taken with meals to minimize gastrointestinal side effects. Do not chew, crush, or break the tablet. It is generally best to take it at the same time every day for optimal results.

What are the possible side effects of VILDAMAC TRIO 500 TAB?

Common side effects may include diarrhea, nausea, vomiting, abdominal pain, headache, frequent urination, vaginal yeast infections (genital mycotic infections), and nasopharyngitis (inflammation of the throat and nasal passages). Hypoglycemia (low blood sugar) can also occur, especially if taken with other antidiabetic medicines, alcohol, or if meals are delayed/skipped.

Is VILDAMAC TRIO 500 TAB safe during pregnancy or breastfeeding?

VILDAMAC TRIO 500 TAB may not be suitable or is generally not recommended during pregnancy or breastfeeding. Limited human data suggests that components of the drug may pass into breast milk. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.

Can VILDAMAC TRIO 500 TAB be taken with other medications?

VILDAMAC TRIO 500 TAB can interact with certain medications. These include cationic medications (like amiloride, digoxin, trimethoprim), iodinated contrast agents, and CYP3A4 inducers (like rifampicin). It is crucial to inform your doctor about all medicines, including over-the-counter drugs, herbal supplements, and vitamins, that you are currently taking to avoid potential drug interactions.

What precautions should be taken while using VILDAMAC TRIO 500 TAB?

Several precautions should be observed:

• Medical Conditions: Inform your doctor if you have kidney problems, liver disease, heart problems, hypertension, or a history of pancreatitis, as dose adjustments or caution may be necessary.
• Alcohol: Limit or avoid alcohol consumption as it can affect blood sugar control and increase the risk of side effects, including hypoglycemia and lactic acidosis.
• Diet: Avoid high-carbohydrate or high-sugar meals to optimize blood sugar control.
• Hydration: Drink plenty of fluids to help prevent dehydration.
• Hygiene: Maintain good hygiene to prevent fungal infections in the genital area.
• Discontinuation: Do not stop taking VILDAMAC TRIO 500 TAB without consulting your doctor, even if your blood sugar levels are controlled, as abrupt cessation can lead to complications.

What happens if a dose of VILDAMAC TRIO 500 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should VILDAMAC TRIO 500 TAB be stored?

Store VILDAMAC TRIO 500 TAB in a cool, dry place, away from direct sunlight. Keep it out of reach of children and do not use the medication beyond its expiration date. Optimal storage temperature is around 25°C.