Sitaglo Mp 500mg Tab

SITAGLO MP 500MG Tablet

Name:

• Brand Name: Sitaglo MP 500 Tablet
• Manufacturer: Aristo Pharmaceuticals Pvt Ltd.

Composition: SITAGLO MP 500 Tablet contains a combination of three active ingredients:

• Metformin Hydrochloride: 500 mg
• Pioglitazone: 15 mg
• Sitagliptin: 100 mg

Uses: SITAGLO MP 500 Tablet is primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. It serves as an adjunct to diet and exercise to improve glycemic control. This medication helps prevent serious complications of diabetes, such as kidney damage, nerve problems, and eye problems. Additionally, the Metformin component may be used for insulin resistance in polycystic ovary syndrome (PCOS).

The active ingredients work synergistically:

• Metformin increases the body's response to insulin, decreases glucose absorption from food, and reduces glucose production by the liver.
• Pioglitazone enhances the body's sensitivity to insulin.
• Sitagliptin increases certain natural substances in the body that lower blood glucose levels.

Dosage and Administration: SITAGLO MP 500 Tablet should be taken orally as advised by your doctor. It is generally recommended to take the tablet with food or a snack to minimize the chance of an upset stomach. For best results, take it regularly and at the same time each day. Do not stop taking this medicine without consulting your doctor, as it may lead to an increase in blood glucose levels.

Side Effects: Common side effects may include:

• Nausea, vomiting, diarrhea, flatulence, abdominal pain, and constipation.
• Headache and stomach upset.
• General weakness.
• Changes in taste.
• Upper respiratory symptoms.
• Low blood sugar (hypoglycemia) can occur, especially when SITAGLO MP 500 Tablet is taken with other anti-diabetic medicines or alcohol, or if meals are delayed or skipped. Symptoms of hypoglycemia include fatigue, dizziness, cold sweats, tremor, and anxiety.

Serious side effects, though rare, warrant immediate medical attention:

• Severe allergic reactions (hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing).
• Severe and persistent stomach pain, with or without nausea and vomiting, which could be a sign of pancreatitis.
• Severe blistering or breakdown of the skin (bullous pemphigoid).
• Kidney problems.
• A rare but serious condition called lactic acidosis, characterized by symptoms like vomiting, stomach pain, difficulty breathing, tiredness, muscle cramps, decreased body temperature, and decreased heartbeat.

Precautions:

• SITAGLO MP 500 Tablet is not suitable for individuals with type 1 diabetes, diabetic ketoacidosis, or severe, uncontrollable diabetes.
• Inform your doctor if you have a history of kidney disease, liver problems, heart problems (including acute heart failure or recent heart attack), pancreatitis, high triglycerides, gallstones, bladder cancer, eye problems caused by diabetes, or bone problems.
• Consult your doctor if you are pregnant or breastfeeding, as information on its use in these conditions is limited or not recommended.
• Avoid or limit alcohol consumption as it can increase the risk of low blood sugar levels and lactic acidosis.
• Your doctor may recommend regular monitoring of your blood sugar levels and kidney function during therapy.
• Always inform your doctor about all other medicines, supplements, or herbal products you are currently taking to avoid potential drug interactions.
• Follow your doctor's recommendations regarding diet and exercise, as these are crucial for effective diabetes management.
• Always carry a source of sugary food or fruit juice to counteract symptoms of hypoglycemia.

Storage: Store SITAGLO MP 500 Tablet in a cool and dry place, below 30°C, and away from direct sunlight. Keep this medicine out of the reach and sight of children.

SITAGLO MP 500MG TAB by ARISTO PHARMA is a combination medication containing Sitagliptin and Metformin, commonly used to manage type 2 diabetes. Here are some frequently asked questions about this medicine:

1. What is SITAGLO MP 500MG TAB used for?

SITAGLO MP 500MG TAB is used, along with a proper diet and exercise program, to control high blood sugar levels in adults with type 2 diabetes. Controlling blood sugar helps prevent complications such as kidney damage, blindness, nerve problems, and loss of limbs, and may also reduce the risk of heart attack or stroke.

2. How does SITAGLO MP 500MG TAB work?

This medicine combines two active ingredients: Sitagliptin and Metformin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of natural substances called incretins, which help the pancreas release more insulin, especially after meals, and signal the liver to reduce sugar production. Metformin is a biguanide that lowers glucose production in the liver, decreases the absorption of sugar from the intestines, and improves the body's sensitivity to insulin, helping it use sugar more effectively.

3. What is the usual dosage for SITAGLO MP 500MG TAB?

The dosage of SITAGLO MP 500MG TAB is individualized by your doctor based on your current regimen, effectiveness, and tolerability. For patients not currently treated with metformin, an initial dose may be 50 milligrams (mg) of sitagliptin and 500 mg of metformin twice daily, taken with meals. The dose can be gradually increased to minimize gastrointestinal side effects. The maximum recommended daily dose is typically 100 mg of sitagliptin and 2000 mg of metformin.

4. What are the possible side effects of SITAGLO MP 500MG TAB?

Common side effects can include nausea, vomiting, stomach upset, diarrhea, headache, weakness, or a metallic taste in the mouth. More serious but rare side effects include lactic acidosis (a build-up of lactic acid in the blood, which is a medical emergency), pancreatitis (inflammation of the pancreas), severe allergic reactions (rash, hives, swelling of face/lips/tongue/throat), and severe joint pain. Long-term use may also lead to Vitamin B12 deficiency.

5. Is SITAGLO MP 500MG TAB safe during pregnancy or breastfeeding?

SITAGLO MP 500MG TAB is generally not recommended during pregnancy. If you are pregnant or planning to become pregnant, you should discuss the risks and benefits with your doctor, as insulin is often preferred for blood glucose control during pregnancy.

Regarding breastfeeding, Metformin passes into breast milk in small quantities and is generally considered safe during breastfeeding by some guidelines. However, the safety of Sitagliptin during breastfeeding is less clear, and it is usually not recommended. Your doctor can help determine the best course of action.

6. Can SITAGLO MP 500MG TAB be taken with other medications?

SITAGLO MP 500MG TAB can interact with other medications. Taking it with insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycemia), and a dose adjustment of these medications might be necessary. Certain medicines, such as some blood pressure medications, diuretics, and some antibiotics, can affect how Sitagliptin/Metformin works. It is crucial to inform your doctor about all prescription, over-the-counter, and herbal products you are taking to avoid potential interactions.

7. What precautions should be taken while using SITAGLO MP 500MG TAB?

Before taking this medication, inform your doctor if you have kidney disease, liver disease, heart failure, a history of pancreatitis, or severe allergic reactions. Excessive alcohol intake should be avoided as it can increase the risk of lactic acidosis and low blood sugar. Your doctor will monitor your kidney function and may periodically check Vitamin B12 levels. You may need to temporarily stop taking this medicine before certain surgeries or diagnostic tests involving contrast dyes.

8. What happens if a dose of SITAGLO MP 500MG TAB is missed?

If you miss a dose of SITAGLO MP 500MG TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

9. How should SITAGLO MP 500MG TAB be stored?

Store SITAGLO MP 500MG TAB at room temperature, away from light and moisture. Keep it out of the reach of children. Do not store it in the bathroom. Keep the container closed when not in use.