Rekool 40 - D

REKOOL 40 - D Capsule SR

REKOOL 40 - D Capsule SR is a combination medicine manufactured by Alembic Pharmaceuticals Limited, commonly prescribed for acid-related gastrointestinal conditions.

• Name:

  • Brand Name: REKOOL 40 - D Capsule SR
  • Common Name: Domperidone and Rabeprazole combination capsule.

• Composition:

  • Each sustained-release capsule contains:
    • Domperidone: 30 mg
    • Rabeprazole: 40 mg

• Uses: REKOOL 40 - D is primarily used to treat conditions involving excessive stomach acid production and impaired gastric motility. These include:

  • Gastroesophageal Reflux Disease (GERD), also known as acid reflux
  • Acidity and heartburn
  • Peptic ulcers (gastric and duodenal ulcers)
  • Zollinger-Ellison Syndrome (a condition causing excessive acid due to a pancreatic tumor)
  • Erosive esophagitis (inflammation and damage to the food pipe)
  • Relief from symptoms like nausea, vomiting, indigestion, and bloating associated with these conditions.

• Dosage and Administration:

  • REKOOL 40 - D Capsule SR should be taken as directed by a healthcare professional.
  • It is generally recommended to take the capsule whole with water, preferably 30 minutes before a meal (typically breakfast), on an empty stomach.
  • Do not chew, crush, or break the capsule.
  • The duration and frequency of treatment depend on the patient's medical condition, age, and response to therapy.

• Side Effects: Most side effects are temporary and resolve over time. Common side effects include:

  • Diarrhea
  • Stomach pain
  • Dry mouth
  • Headache
  • Dizziness
  • Flatulence (gas)
  • Weakness
  • Nausea and vomiting
  • Constipation

  More serious, though less common, side effects can occur with prolonged use, such as low levels of magnesium and vitamin B12, and an increased risk of bone fractures. Persistent or worsening symptoms should prompt medical consultation.

• Precautions:

  • Alcohol: Avoid alcohol consumption as it may worsen drowsiness and increase stomach acid production.
  • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant, planning pregnancy, or breastfeeding.
  • Driving and Operating Machinery: This medicine may cause dizziness and drowsiness; avoid activities requiring mental alertness until you know how it affects you.
  • Medical Conditions: Inform your doctor if you have liver disease, kidney disease, stomach tumor, heart problems (including heart failure, heart rhythm problems, or electrolyte imbalance), or a history of fractures/osteoporosis.
  • Drug Interactions: Inform your doctor about all other medicines you are taking, especially blood-thinning or antifungal medicines, and HIV medicines like ritonavir, as interactions can occur.
  • Prolonged use may lead to increased risk of Clostridium difficile-associated diarrhea.

• Storage:

  • Store in a cool, dry place.
  • Protect from direct sunlight.
  • Keep out of reach of children.

REKOOL 40-D, manufactured by Alembic Pharmaceuticals Limited, is a combination medicine containing Domperidone (30mg) and Rabeprazole (40mg). It is primarily used to manage conditions related to excessive stomach acid.

What is REKOOL 40-D used for?

REKOOL 40-D is used to treat gastroesophageal reflux disease (GERD), which is a chronic condition where stomach acid flows back into the food pipe, causing symptoms like heartburn and irritation. It also treats peptic ulcers (gastric and duodenal ulcers), Zollinger-Ellison syndrome (a condition causing excessive acid production), acidity, and erosive esophagitis (inflammation and damage to the food pipe lining).

How does REKOOL 40-D work?

REKOOL 40-D works through its two active ingredients: Domperidone and Rabeprazole. Rabeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach by blocking the action of an enzyme responsible for acid secretion. Domperidone is a prokinetic agent that increases the movement of the stomach and intestines, helping food move more easily through the digestive tract and controlling vomiting.

What is the usual dosage for REKOOL 40-D?

The recommended dosage of REKOOL 40-D is typically one capsule daily, preferably in the morning, about 30-60 minutes before a meal. It should be swallowed whole with a glass of water and not crushed, chewed, or broken. The specific dose and duration of treatment will be determined by your doctor based on your condition and response to the medicine.

What are the possible side effects of REKOOL 40-D?

Common side effects include diarrhea, stomach pain, dry mouth, headache, flatulence (gas), weakness, dizziness, nausea, and vomiting. Most of these effects are temporary and usually resolve over time. More serious but rare side effects can include severe allergic reactions, liver problems (yellow skin, dark urine), severe skin reactions, seizures, and kidney damage. Long-term use may also lead to deficiencies in vitamin B12 and magnesium, and an increased risk of bone fractures.

Is REKOOL 40-D safe during pregnancy or breastfeeding?

REKOOL 40-D is generally not recommended for use during pregnancy or breastfeeding. It may be unsafe for use during pregnancy, and limited human data suggests the drug may pass into breast milk and harm the baby. It is crucial to consult your doctor to discuss the potential risks and benefits before taking this medicine if you are pregnant or breastfeeding.

Can REKOOL 40-D be taken with other medications?

REKOOL 40-D can interact with certain medications. It may affect the action of antiviral medicines (like Rilpivirine, Atazanavir, Nelfinavir), antifungals (like Ketoconazole, Itraconazole, Posaconazole), heart failure medicines (like digoxin), and some antidepressants. Caution is also advised with blood thinners (like Warfarin) due to an increased risk of bleeding. If you are taking antacids, it is advisable to maintain a gap of at least 2 hours between taking them and REKOOL 40-D. Always inform your doctor about all other medications, including supplements and herbal products, you are taking.

What precautions should be taken while using REKOOL 40-D?

Exercise caution if you have liver or kidney disease, heart problems (such as prolonged QT interval), a stomach tumor, a history of fractures, or osteoporosis. Prolonged use may lead to low levels of vitamin B12 and magnesium, and an increased risk of bone fractures. Alcohol consumption should be avoided as it can worsen drowsiness and increase stomach acid production. This medicine may cause dizziness or drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. REKOOL 40-D is not recommended for children below 12 years of age.

What happens if a dose of REKOOL 40-D is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should REKOOL 40-D be stored?

REKOOL 40-D should be stored in a cool, dry place, away from direct sunlight, typically below 25°C or 30°C. Keep the medicine in its original container, tightly closed, and out of the sight and reach of children.