DAPAGLYN M 500 MG TABLET (15 TAB) by ZYDUS HEALTHCARE LIMITED

DAPAGLYN M 500 MG TABLET is a combination medication primarily used for the management of type 2 diabetes mellitus in adults. This oral antidiabetic medicine helps in controlling high blood sugar levels and reducing the risk of associated serious complications, including kidney damage, eye problems, nerve damage, and cardiovascular events such as heart attack or heart failure.

• Composition

  • Active Ingredients: Each tablet contains Dapagliflozin 10 mg and Metformin 500 mg.
  • Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by blocking the re-absorption of glucose in the kidneys, leading to increased glucose excretion through urine.
  • Metformin is a biguanide that reduces glucose production in the liver, delays glucose absorption from the intestines, and enhances the body's sensitivity to insulin.

• Uses

  • Treatment of type 2 diabetes mellitus to control high blood glucose levels.
  • Improvement of glycemic control.
  • Reduction in the risk of complications associated with diabetes, such as neuropathy, retinopathy, kidney issues, and cardiovascular events.

• Dosage and Administration DAPAGLYN M 500 TABLET is taken orally, usually once daily, preferably in the morning, and often with food to minimize stomach upset. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. The exact dosage and duration of treatment are determined by a doctor based on the individual's medical condition and response to treatment. It is important to take the medication at the same time each day for consistent effectiveness.

• Side Effects Common side effects may include:

  • Nausea, vomiting, diarrhea, stomach ache, loss of appetite
  • Headache, dizziness
  • Frequent urination, urinary tract infections (UTIs)
  • Genital fungal infections (yeast infections)
  • Mild skin rash or itchy skin, taste changes, flatulence
  • Nasopharyngitis (inflammation of the throat and nasal passages)

  A rare but serious side effect associated with Metformin is lactic acidosis, symptoms of which include extreme weakness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, feeling cold, dizziness, and a slow or irregular heartbeat. Immediate medical attention is required if these symptoms occur.

• Precautions

  • DAPAGLYN M 500 TABLET is not for type 1 diabetes mellitus.
  • It is contraindicated in patients with severe kidney or liver disease, diabetic ketoacidosis, severe infection, or dehydration.
  • Individuals with a known allergy to dapagliflozin, metformin, or any other components of the tablet should not take this medication.
  • Caution is advised for pregnant or breastfeeding women; a doctor should be consulted.
  • Excessive alcohol consumption should be avoided as it may increase the risk of side effects, including lactic acidosis.
  • Regular monitoring of kidney function is recommended, especially in patients with kidney disease.
  • Inform your doctor about any history of heart disease, low blood pressure, or recurrent urinary tract infections.
  • Do not stop taking the medicine without consulting your doctor, as abrupt discontinuation can lead to increased blood sugar levels and severe complications.

• Storage Store DAPAGLYN M 500 TABLET in a cool and dry place, typically below 30°C, away from direct sunlight. Keep out of the sight and reach of children.

DAPAGLYN M 500 MG TABLET FAQs

What is DAPAGLYN M 500 MG TABLET used for?

DAPAGLYN M 500 MG TABLET is used to manage type 2 diabetes mellitus in adults, particularly when diet and exercise alone are not enough to control blood sugar levels. It helps improve glycemic control and can also reduce the risk of diabetes-related complications such as neuropathy, retinopathy, kidney issues, and cardiovascular events like heart attack or heart failure.

How does DAPAGLYN M 500 MG TABLET work?

DAPAGLYN M 500 MG TABLET contains two active ingredients: Dapagliflozin (10 mg) and Metformin (500 mg).

• Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose in the kidneys, which leads to increased glucose excretion through urine, thereby lowering blood sugar levels.
• Metformin is a biguanide that reduces glucose production in the liver, decreases glucose absorption from the intestines, and enhances the body's sensitivity to insulin, allowing cells to utilize glucose more effectively. Together, these ingredients work synergistically to maintain optimal blood sugar levels.

What is the usual dosage for DAPAGLYN M 500 MG TABLET?

The dosage of DAPAGLYN M 500 MG TABLET is determined by your doctor. It should be taken orally as directed by your physician, usually with food. It is crucial not to alter your dosage or stop taking the medicine without consulting your doctor, as this can lead to increased blood sugar levels and serious complications.

What are the possible side effects of DAPAGLYN M 500 MG TABLET?

Common side effects can include nausea, vomiting, diarrhea, urinary tract infections (UTIs), increased urination, genital fungal infections, flatulence, skin rash, taste changes, and nasopharyngitis (inflammation of the nose and throat). In some cases, it may also lead to low blood sugar (hypoglycemia), especially when taken with other antidiabetic medicines or alcohol. Most side effects are temporary and resolve over time, but if any persist or worsen, you should consult your doctor.

Is DAPAGLYN M 500 MG TABLET safe during pregnancy or breastfeeding?

Caution is advised when taking DAPAGLYN M 500 MG TABLET during pregnancy, and it is generally not recommended in the second and third trimesters due to insufficient safety data and potential risks to the unborn baby. Similarly, it is not advised during breastfeeding as dapagliflozin may pass into breast milk and affect the infant's kidney development. Always consult your doctor for advice on alternative options if you are pregnant, planning to conceive, or breastfeeding.

Can DAPAGLYN M 500 MG TABLET be taken with other medications?

DAPAGLYN M 500 MG TABLET can interact with certain medications. For example, taking it with diuretics (like furosemide or hydrochlorothiazide) may increase the risk of dehydration and low blood pressure. When used with insulin or insulin secretagogues (e.g., glimepiride), there is an increased risk of low blood sugar. Medicines affecting kidney function (like ibuprofen or naproxen) can also interfere with its excretion. It should not be used with iodinated contrast agents for X-rays or certain medicines for stomach acidity like cimetidine. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken with DAPAGLYN M 500 MG TABLET?

• Alcohol Consumption: Avoid excessive alcohol consumption as it may increase the risk of poor blood sugar control and serious complications like lactic acidosis.
• Kidney and Liver Conditions: Exercise caution if you have kidney or liver problems, as the medication can affect organ function and may exacerbate existing conditions. This medication is contraindicated in severe kidney or liver disease.
• Dehydration: Stay well-hydrated by drinking plenty of fluids to prevent dehydration, as the medication can increase urination.
• Hygiene: Practice good genital hygiene to reduce the risk of fungal infections.
• Driving and Machinery: Your ability to drive or operate machinery may be affected if your blood sugar levels are too high or too low.
• Other Conditions: Inform your doctor if you have type 1 diabetes, diabetic ketoacidosis, severe infection, heart failure, or a history of low blood pressure.

What happens if a dose of DAPAGLYN M 500 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Never alter your dosage without consulting your doctor.

How should DAPAGLYN M 500 MG TABLET be stored?

DAPAGLYN M 500 MG TABLET should be stored at room temperature, ideally between 20 to 25 degrees Celsius, and kept away from direct heat, moisture, and light. Keep it out of sight and reach of children. Do not keep outdated medicine.