Glz Total Tablet

GLZ TOTAL TABLET by ALEMBIC PHARMACEUTICALS LTD

GLZ TOTAL TABLET is a combination antidiabetic medication manufactured by Alembic Pharmaceuticals Ltd., prescribed for the management of Type 2 Diabetes Mellitus in adults. It is typically used when diet, exercise, and management with single agents or dual therapy do not achieve adequate blood sugar control.

Composition Each GLZ TOTAL TABLET contains a combination of three active ingredients:

• Gliclazide 60 mg (in modified-release form)
• Metformin 500 mg (in extended-release form)
• Pioglitazone 15 mg

Uses GLZ TOTAL TABLET is used for the treatment of Type 2 Diabetes Mellitus. It works by:

• Increasing insulin secretion from the pancreas (Gliclazide).
• Lowering glucose production in the liver (Metformin, Pioglitazone).
• Delaying glucose absorption from the intestines (Metformin).
• Improving the body's sensitivity to insulin (Metformin, Pioglitazone).

This comprehensive action helps to control high blood sugar levels and prevent serious complications of diabetes, such as kidney damage, eye problems, nerve issues, and limb loss. Some sources also suggest benefits in improving cholesterol levels and blood pressure, and managing insulin resistance in Polycystic Ovary Syndrome (PCOS).

Dosage and Administration GLZ TOTAL TABLET should be taken orally with food, preferably at the same time each day, as directed by a healthcare professional. The tablet should be swallowed whole with water and not crushed, broken, or chewed. The dosage is individualized by the doctor based on the patient's blood sugar levels and other medical factors. Consistent use is important, and the medication should not be stopped without consulting a doctor.

Side Effects Common side effects may include:

• Hypoglycemia (low blood sugar levels)
• Nausea, vomiting, diarrhea, stomach pain, flatulence, loss of appetite
• Changes in taste, metallic taste
• Headache, dizziness
• Weight gain, edema (swelling)
• Muscle pain, joint pain, back pain, impotence
• Respiratory infection, sinus infection, sore throat, bronchitis, anemia

Serious side effects, though less common, require immediate medical attention:

• Signs of lactic acidosis (e.g., cold hands or feet, unusual muscle pain, trouble breathing, severe tiredness, stomach pain, nausea, vomiting)
• Symptoms of heart failure (e.g., unusual shortness of breath, rapid weight increase, localized swelling, especially in ankles or legs)
• Severe allergic reactions (e.g., rash, swelling, difficulty breathing)

Precautions GLZ TOTAL TABLET is contraindicated in individuals with Type 1 Diabetes Mellitus, diabetic ketoacidosis, severe heart failure, lactic acidosis, bladder cancer, severe kidney or liver disease, and in those allergic to any of its components. It is not recommended for use in pregnant or breastfeeding women, or in children under 18 years of age.

Patients should inform their doctor about any existing liver, kidney, or heart problems, eye problems, hormonal imbalances, or a history of alcoholism. Alcohol consumption is unsafe as it increases the risk of hypoglycemia and lactic acidosis. Regular monitoring of blood sugar levels, kidney, and liver function is crucial during treatment. Patients should avoid driving or operating heavy machinery if they experience dizziness or vision changes. Lifestyle modifications, including a healthy diet and regular exercise, are essential alongside this medication.

Storage Store GLZ TOTAL TABLET below 30°C, protected from moisture, heat, and direct light. Keep out of reach of children.

What is GLZ TOTAL TABLET used for?

GLZ TOTAL TABLET is primarily used to treat Type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and weight loss alone, or treatment with single or dual antidiabetic agents, are not sufficient to adequately control blood sugar levels. It helps manage high blood sugar, improve insulin sensitivity, and can reduce the risk of diabetes complications such as kidney damage, nerve problems, and eye damage. It may also be used to manage insulin resistance in Polycystic Ovary Syndrome (PCOS).

How does GLZ TOTAL TABLET work?

GLZ TOTAL TABLET is a combination medicine containing Gliclazide, Metformin, and Pioglitazone, which work synergistically to lower blood sugar.

• Gliclazide (a sulfonylurea) stimulates the beta cells in the pancreas to release more insulin.
• Metformin (a biguanide) reduces glucose production in the liver, delays glucose absorption from the intestines, and improves the body's sensitivity to insulin.
• Pioglitazone (a thiazolidinedione) enhances insulin sensitivity in peripheral tissues like muscle and fat, allowing cells to utilize glucose more effectively.

What is the usual dosage for GLZ TOTAL TABLET?

The dosage of GLZ TOTAL TABLET varies depending on individual patient factors, including the severity of diabetes, kidney function, and other medical conditions. Your doctor will determine the most appropriate dosage, which typically starts low and is gradually increased to achieve optimal blood glucose control. It is generally taken once or twice daily, preferably with meals, and should be swallowed whole without crushing, chewing, or breaking.

What are the possible side effects of GLZ TOTAL TABLET?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, drowsiness, weakness, fatigue, skin rash, and itching. More serious, but less common, side effects can include hypoglycemia (low blood sugar), liver problems, changes in blood cell counts, edema (swelling), and lactic acidosis (a life-threatening condition characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing).

Is GLZ TOTAL TABLET safe during pregnancy or breastfeeding?

GLZ TOTAL TABLET is generally not recommended for use during pregnancy and is probably unsafe during breastfeeding. It is crucial to consult your doctor before using this medication if you are pregnant, planning to become pregnant, or are breastfeeding, as alternative treatment options may be advised.

Can GLZ TOTAL TABLET be taken with other medications?

GLZ TOTAL TABLET can interact with several other medications. It is important to inform your doctor about all prescription and over-the-counter medicines, supplements, and herbal remedies you are currently taking to avoid potential drug interactions. Concomitant use with certain medications, such as some pain killers, antibiotics, antifungals, and alcohol, can increase the risk of side effects like hypoglycemia or lactic acidosis.

What precautions should be taken while using GLZ TOTAL TABLET?

Before taking GLZ TOTAL TABLET, inform your doctor about any existing medical conditions, especially kidney or liver problems, heart disease (including a history of heart failure), bladder cancer, or severe infections. Alcohol consumption should be avoided or limited as it can increase the risk of lactic acidosis and hypoglycemia. Regular monitoring of blood sugar levels, kidney and liver function, and blood cell counts is essential. You should also maintain a healthy diet and regular exercise as advised by your doctor.

What happens if a dose of GLZ TOTAL TABLET is missed?

If you miss a dose of GLZ TOTAL TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should GLZ TOTAL TABLET be stored?

GLZ TOTAL TABLET should be stored at room temperature (below 30°C or 25°C), away from direct sunlight, heat, and moisture. Keep it out of the reach and sight of children and pets.