Arnoza 50 Mg Tablet

ARNOZA 50 MG TABLET

Name: Arnoza 50 mg Tablet

Composition: Arnoza 50 mg Tablet contains two active ingredients: Sacubitril (24 mg) and Valsartan (26 mg). This combination is classified as an angiotensin receptor-neprilysin inhibitor (ARNI).

Uses: This medicine is primarily prescribed for the management of chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to relax and widen blood vessels, making it easier for the heart to pump blood, improve heart efficiency, and reduce the risk of hospitalization and cardiovascular death due to heart failure. It can also help alleviate symptoms such as shortness of breath and fatigue.

Dosage and Administration: Arnoza 50 mg Tablet should be swallowed whole with a glass of water, without crushing, chewing, or splitting. It can be taken with or without food, but it is recommended to take it at the same time each day for maximum benefit. The dosage and frequency are determined by your doctor based on your medical condition and response to the medicine. Do not alter the dose without consulting your healthcare provider.

Side Effects:

• Common Side Effects: Low blood pressure (hypotension), high potassium levels (hyperkalemia), kidney dysfunction, cough, dizziness, diarrhea, headache, and fatigue.
• Serious Side Effects: Severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing).

Precautions:

• Allergies: Do not take Arnoza 50 mg Tablet if you are allergic to Sacubitril, Valsartan, or any other ingredients in the medicine, or if you have a history of angioedema.
• Drug Interactions:
  • ACE Inhibitors: Do not take Arnoza 50 mg Tablet with ACE inhibitors (e.g., enalapril, lisinopril) due to an increased risk of angioedema and low blood pressure. A washout period of at least 36 hours is required before or after taking an ACE inhibitor.
  • ARBs: Other angiotensin receptor blockers like losartan can increase the risk of hypotension.
  • Potassium-Sparing Diuretics: Concomitant use with diuretics like spironolactone or amiloride may increase blood potassium levels.
  • Aliskiren: Avoid if you have diabetes or impaired kidney function and are being treated with Aliskiren.
• Medical Conditions: Inform your doctor if you have liver disease (caution with mild to moderate impairment, contraindicated in severe), severe kidney disease, low blood pressure, dehydration, or a history of hereditary angioedema.
• Pregnancy and Breastfeeding: Arnoza 50 mg Tablet is contraindicated during pregnancy, especially after the first trimester, due to potential harm to the baby. It is also not recommended for breastfeeding women.
• Alcohol: Caution is advised regarding alcohol consumption, and it is generally considered unsafe with this medication.
• Driving and Machinery: May cause dizziness, so caution is advised when driving or operating machinery.
• Diet: Limit salt intake and consult your doctor about potassium-rich foods, as this medicine can raise potassium levels.

Storage: Keep Arnoza 50 mg Tablet in its original packaging to protect it from moisture. Store it at room temperature below 30°C (or between 10°C to 25°C), away from light, and out of the reach and sight of children. Ensure it is used before the expiry date.

Here are some frequently asked questions about ARNOZA 50 MG TABLET:

What is ARNOZA 50 MG TABLET used for?

ARNOZA 50 MG TABLET is used to treat long-term (chronic) heart failure in adults. It helps reduce the risk of cardiovascular death and hospitalization in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction, which means the heart isn't pumping blood as efficiently as it should.

How does ARNOZA 50 MG TABLET work?

This medicine is a combination of two active ingredients, Sacubitril and Valsartan, belonging to a class of drugs called Angiotensin Receptor Neprilysin Inhibitors (ARNI). Sacubitril works by inhibiting an enzyme called neprilysin, which increases the levels of certain beneficial peptides that relax and widen blood vessels. Valsartan is an angiotensin receptor blocker (ARB) that blocks the action of angiotensin-II, a substance that causes blood vessels to narrow. Together, they help relax blood vessels, reduce the workload on the heart, improve blood flow, and aid in the removal of excess fluid from the body.

What is the usual dosage for ARNOZA 50 MG TABLET?

Your doctor will determine the correct dose and duration of ARNOZA 50 MG TABLET based on your age, body weight, and medical condition. It can be taken with or without food, but it is recommended to take it at the same time each day for maximum benefit. Swallow the tablet whole with a glass of water; do not crush or chew it.

What are the possible side effects of ARNOZA 50 MG TABLET?

Common side effects may include dizziness, low blood pressure (hypotension), cough, headache, tiredness, nausea, diarrhea, increased potassium levels in the blood (hyperkalemia), and kidney dysfunction. In rare cases, severe allergic reactions like angioedema (swelling of the face, lips, tongue, or throat, potentially causing difficulty breathing) can occur. Consult your doctor if any side effects worsen or persist.

Is ARNOZA 50 MG TABLET safe during pregnancy or breastfeeding?

No, ARNOZA 50 MG TABLET is not recommended and is contraindicated during pregnancy, especially after the first three months, as it can cause serious harm to the unborn baby. It is also not recommended for use by breastfeeding women. Always inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can ARNOZA 50 MG TABLET be taken with other medications?

ARNOZA 50 MG TABLET can interact with certain other medications. It should not be taken with ACE inhibitors (e.g., enalapril, lisinopril, ramipril); a gap of at least 36 hours is required before or after taking an ACE inhibitor to avoid increased risk of side effects like angioedema. It may also interact with other angiotensin receptor blockers (ARBs), aliskiren (especially in patients with diabetes or kidney impairment), potassium supplements, potassium-sparing diuretics (e.g., spironolactone), NSAIDs (e.g., ibuprofen, naproxen), and lithium. Inform your doctor about all medications you are currently taking.

What precautions should be taken while using ARNOZA 50 MG TABLET?

Inform your doctor about any pre-existing medical conditions, especially liver, kidney, or heart problems, diabetes, or a history of angioedema. This medicine may cause dizziness or tiredness, so exercise caution when driving or operating machinery. Your doctor may recommend regular monitoring of your blood pressure and kidney function. It is also advisable to maintain a low-sodium diet and discuss an appropriate exercise regimen with your doctor.

What happens if a dose of ARNOZA 50 MG TABLET is missed?

If you miss a dose of ARNOZA 50 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten tablet.

How should ARNOZA 50 MG TABLET be stored?

Store ARNOZA 50 MG TABLET in its original packaging at room temperature, typically below 30°C. Keep it in a cool, dry place, away from direct sunlight and moisture. Ensure it is kept out of the reach and sight of children.