Proluton Depot 250 Mg/1 Ml Injection

PROLUTON DEPOT 250 MG/1 ML INJECTION

Proluton Depot is a pharmaceutical injection primarily prescribed for women during pregnancy to help prevent preterm birth.

• Name:
  • Brand Name: Proluton Depot 250 MG/1 ML INJECTION
  • Common Name: Hydroxyprogesterone Caproate
• Composition:
  • Active Ingredient: Hydroxyprogesterone Caproate 250 mg/1 ml
  • Other Ingredients: Oily solution, typically containing castor oil and benzyl benzoate
• Uses:
  • Reducing the risk of recurrent preterm birth in women with a history of singleton spontaneous preterm delivery.
  • Supporting the maintenance of pregnancy by promoting uterine quiescence and a healthy uterine lining.
  • Management of habitual and threatened abortion.
• Dosage and Administration:
  • Administered via deep intramuscular injection by a healthcare professional.
  • For preterm birth prevention, typically 250 mg is given once weekly, starting between 16 to 20 weeks of gestation and continuing until 37 weeks or delivery.
  • Dosage for abortion prevention may vary, sometimes 250-500 mg weekly, or 500 mg 2-3 times weekly for acute cases.
  • Should not be self-administered.
• Side Effects:
  • Common: Injection site reactions (pain, swelling, itching, lump), nausea, diarrhea, headache, dizziness, fatigue, fever, skin rash.
  • Serious: Signs of blood clots (e.g., leg swelling, pain), severe allergic reactions (e.g., angioedema), decreased glucose tolerance, fluid retention, depression, jaundice, or high blood pressure.
• Precautions:
  • Contraindicated in patients with liver disease or tumors, active thrombosis, hormone-sensitive cancers, uncontrolled hypertension, or unexplained vaginal bleeding.
  • Use with caution in patients with a history of asthma, kidney or heart problems, diabetes, epilepsy, or migraine.
  • Monitor blood sugar levels, especially in diabetic or pre-diabetic patients.
  • May cause dizziness; exercise caution when driving or operating machinery.
  • Not recommended for use in the first trimester of pregnancy or in women with multiple gestations.
• Storage:
  • Store in a cool and dry place, away from direct sunlight.
  • Maintain a controlled room temperature, typically between 10ºC to 25ºC or below 30ºC.
  • Keep out of the reach of children.

PROLUTON DEPOT 250 MG/1 ML INJECTION by GERMAN REMEDIES is a medication primarily used in pregnant women to help prevent premature labor and reduce the risk of preterm birth. It contains hydroxyprogesterone caproate, a synthetic progestin (female hormone). The injection is administered intramuscularly by a healthcare professional.

What is PROLUTON DEPOT 250 MG/1 ML INJECTION used for?

PROLUTON DEPOT 250 MG/1 ML INJECTION is primarily used to reduce the risk of preterm birth in women who have a history of singleton spontaneous preterm delivery. It also helps in maintaining a state of rest in the uterus during pregnancy and supports the healthy maintenance of the uterine lining. In some cases, it may also be used to help prevent miscarriage.

How does PROLUTON DEPOT 250 MG/1 ML INJECTION work?

This injection contains hydroxyprogesterone caproate, a man-made form of the female hormone progesterone. It works by promoting uterine quiescence, which means it helps to suppress uterine contractions that could lead to preterm birth. It also assists in maintaining the uterine lining, which is crucial for the healthy growth and development of the fetus, and can modulate the immune response to prevent embryo rejection.

What is the usual dosage for PROLUTON DEPOT 250 MG/1 ML INJECTION?

For reducing the risk of preterm birth in women with a history of singleton spontaneous preterm delivery, the usual dosage is 250 mg administered once weekly (every 7 days) via a slow intramuscular injection. Treatment typically starts between 16 weeks, 0 days and 20 weeks, 6 days of gestation and continues until week 37 of gestation or delivery, whichever comes first. This injection must always be administered by a trained healthcare professional and should not be self-administered.

What are the possible side effects of PROLUTON DEPOT 250 MG/1 ML INJECTION?

Common side effects can include reactions at the injection site such as pain, swelling, itching, a lump, or bruising. Other common side effects may include nausea, diarrhea, headache, dizziness, fatigue, fever, and skin rash. More serious, though less common, side effects that require immediate medical attention include signs of blood clots (e.g., leg swelling, redness, warmth, pain), allergic reactions (e.g., swelling of the face, lips, tongue, or throat), decreased glucose tolerance, fluid retention, depression, jaundice, or high blood pressure.

Is PROLUTON DEPOT 250 MG/1 ML INJECTION safe during pregnancy or breastfeeding?

PROLUTON DEPOT is used during pregnancy specifically to reduce the risk of preterm birth and is generally considered safe when prescribed for this purpose. However, it is not recommended for women with multiple pregnancies (e.g., twins, triplets) or those with certain conditions like cholestatic jaundice of pregnancy. Regarding breastfeeding, small amounts of the medicine may pass into breast milk, so it's best to consult your doctor before using this medication while breastfeeding.

Can PROLUTON DEPOT 250 MG/1 ML INJECTION be taken with other medications?

PROLUTON DEPOT can interact with certain medications. For instance, some antibiotics like rifampin may decrease its effectiveness. Medications affecting glucose tolerance, such as corticosteroids, might also impact its efficacy. It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take to avoid potential interactions. Other potential interactions can include certain antidepressants, antidiabetics, and drugs for epilepsy.

What precautions should be taken while using PROLUTON DEPOT 250 MG/1 ML INJECTION?

You should not use PROLUTON DEPOT if you have a history of or current liver problems (including liver tumors or active liver disease), breast cancer or other hormone-sensitive cancers, thrombosis or thromboembolic disorders (blood clots), uncontrolled high blood pressure, or undiagnosed abnormal vaginal bleeding unrelated to pregnancy. Caution is advised for patients with asthma, kidney or heart problems, diabetes, epilepsy, migraine, or a history of depression. Since it can cause dizziness, avoid driving or operating heavy machinery if you experience this side effect. Regular monitoring of blood sugar levels is important, especially for individuals with diabetes.

What happens if a dose of PROLUTON DEPOT 250 MG/1 ML INJECTION is missed?

If you miss a dose of PROLUTON DEPOT, you should consult your doctor immediately for advice. Generally, you should take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. In that case, it is usually best to skip the missed dose and continue with your regular dosing schedule, without doubling up on doses. Do not try to catch up on missed doses without consulting your doctor.

How should PROLUTON DEPOT 250 MG/1 ML INJECTION be stored?

PROLUTON DEPOT 250 MG/1 ML INJECTION should be stored in a cool and dry place, away from direct sunlight. It should be kept out of sight and reach of children. The recommended storage temperature is below 25°C or between 10°C to 25°C, or below 30°C. It should not be frozen.