Glucreta Gm 1/10/500 Tab

GLUCRETA GM 1/10/500 TAB

GLUCRETA GM 1/10/500 Tablet by Torrent Pharmaceuticals Ltd. is a combination medication used to manage Type 2 Diabetes Mellitus in adults.

Composition Each tablet contains:

• Dapagliflozin: 10 mg
• Glimepiride: 1 mg
• Metformin: 500 mg

Uses GLUCRETA GM is prescribed for the following:

• Controlling high blood sugar levels in adults with Type 2 Diabetes Mellitus.
• Used as an adjunct therapy alongside diet and exercise to improve glycemic control.
• It works by improving the body's response to insulin, stimulating insulin release from the pancreas, reducing glucose production in the liver, and increasing the removal of excess sugar through urine.

Dosage and Administration Take this medicine as prescribed by your doctor, usually once daily. It can be taken with or without food, though taking it with meals may help reduce stomach upset. For optimal effectiveness, take it at the same time each day and adhere to your doctor's recommended diet and exercise plan. Do not discontinue use without consulting your doctor.

Side Effects Common Side Effects:

• Hypoglycemia (low blood glucose level)
• Dizziness, weakness, headache
• Nausea, vomiting, abdominal pain, diarrhea
• Weight gain
• Urinary tract infections, female genital infections
• Nasopharyngitis (common cold symptoms)

Serious Side Effects (seek immediate medical attention):

• Lactic acidosis (a rare but severe buildup of lactic acid in the blood)
• Severe urinary tract infections
• Allergic reactions such as swelling, skin rashes, wheezing, chest tightness, or seizures.

Precautions

• Allergies: Avoid if allergic to any components or if you have a sulfa allergy.
• Kidney/Liver Issues: Use with caution in patients with kidney or liver problems. It is contraindicated in severe kidney disease (eGFR below 30 ml/min/1.73 m²) or very bad liver disease due to increased risk of lactic acidosis.
• Pregnancy & Breastfeeding: Generally not recommended during pregnancy or breastfeeding; consult your doctor.
• Alcohol: Limit or avoid alcohol consumption as it may increase the risk of lactic acidosis and hypoglycemia.
• Other: Inform your doctor about all current medications, including herbal supplements. Regular monitoring of blood sugar, kidney, and liver function is necessary. Caution is advised for elderly patients and the medicine is not recommended for children under 18 years.

Storage Store GLUCRETA GM tablets at room temperature (20-25°C) or below 30°C, away from moisture, heat, and direct sunlight. Keep the medicine in its original packaging and out of the sight and reach of children.

What is GLUCRETA GM 1/10/500 TAB used for?

GLUCRETA GM 1/10/500 TAB is an antidiabetic medicine primarily used to treat Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels, especially when lifestyle changes and other treatments are insufficient. This medication aims to improve glycemic control, reduce HbA1c levels, and prevent diabetes-related complications such as kidney damage, nerve issues, and heart disease.

How does GLUCRETA GM 1/10/500 TAB work?

GLUCRETA GM 1/10/500 TAB is a combination of three active ingredients: Dapagliflozin (10 mg), Glimepiride (1 mg), and Metformin (500 mg).

• Dapagliflozin (a sodium-glucose cotransporter-2 inhibitor or SGLT2 inhibitor) works by blocking special proteins in the kidneys, which leads to increased removal of excess sugar from the body through urine.
• Glimepiride (a sulfonylurea) stimulates the beta cells in the pancreas to produce and release more insulin, a natural substance needed to break down sugar in the body.
• Metformin (a biguanide) helps control blood sugar by decreasing the amount of glucose absorbed from food and the amount produced by the liver, while also improving the body's response to insulin.

Together, these ingredients work to enhance insulin secretion, improve how the body responds to insulin, and increase the elimination of excess glucose.

What is the usual dosage for GLUCRETA GM 1/10/500 TAB?

The dosage of GLUCRETA GM 1/10/500 TAB should be taken as prescribed by your doctor. It is typically taken once daily, usually with the first meal of the day. Do not adjust the dose or stop taking the medication without consulting your doctor.

What are the possible side effects of GLUCRETA GM 1/10/500 TAB?

Common side effects of GLUCRETA GM 1/10/500 TAB can include vomiting, nausea, abdominal pain, headache, and allergic reactions. Other potential side effects include hypoglycemia (low blood sugar), dizziness, increased urination, genital fungal infections, and weight gain. Serious side effects may include lactic acidosis (a rare but life-threatening buildup of lactic acid in the blood) and severe urinary tract infections.

Is GLUCRETA GM 1/10/500 TAB safe during pregnancy or breastfeeding?

GLUCRETA GM 1/10/500 TAB may not be safe to use during pregnancy and is generally not recommended for breastfeeding mothers. It is important to inform your doctor if you are pregnant, planning to conceive, or breastfeeding before taking this medicine.

Can GLUCRETA GM 1/10/500 TAB be taken with other medications?

GLUCRETA GM 1/10/500 TAB can interact with certain other medications. It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

• Diuretics (water pills) may increase the risk of dehydration and low blood pressure.
• Insulin and insulin secretagogues (like glibenclamide or gliclazide) may increase the risk of extremely low blood sugar levels (hypoglycemia).
• Carbonic anhydrase inhibitors (e.g., acetazolamide, topiramate) may increase the risk of lactic acidosis when taken with metformin.
• Corticosteroids may decrease the blood sugar-lowering effect of GLUCRETA GM.
• It should also be avoided if undergoing X-rays with iodinated contrast agents.

What precautions should be taken when using GLUCRETA GM 1/10/500 TAB?

• Allergies: Avoid taking this medicine if you are allergic to dapagliflozin, glimepiride, metformin, or any other ingredients in the tablet, or if you have a sulfa allergy.
• Kidney and Liver Issues: Inform your doctor if you have any liver or kidney disease, as the medicine should be used with caution in such cases, and it is contraindicated in severe kidney disease.
• Alcohol Consumption: Avoid or limit alcohol intake, as it can increase the risk of hypoglycemia and lactic acidosis.
• Children: This medicine is not recommended for use in children below 18 years of age.
• Other Conditions: Inform your doctor if you have heart problems, hypertension, diabetic ketoacidosis, severe infection, or are dehydrated.
• Monitoring: Regular monitoring of blood sugar levels, kidney function, and liver function may be necessary.
• Dehydration: Stay hydrated as this medicine may increase urination.

What happens if a dose of GLUCRETA GM 1/10/500 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should GLUCRETA GM 1/10/500 TAB be stored?

Store GLUCRETA GM 1/10/500 TAB in a cool and dry place, away from direct sunlight. It should be kept at room temperature (20-25°C or below 30°C) and out of the sight and reach of children. Keep it in its original packaging and protect it from moisture and light.