Dapalex 10 Mg Tablet (15 Tab)

DAPALEX 10 MG Tablet

DAPALEX 10 MG Tablet is a prescription medication manufactured by AJANTA PHARMA LIMITED.

Composition

The active ingredient in DAPALEX 10 MG Tablet is Dapagliflozin 10 mg. It belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors.

Uses

DAPALEX 10 MG Tablet is primarily used in the management of:

• Type 2 Diabetes Mellitus: It is prescribed as an adjunct to diet and exercise to improve blood sugar (glucose) control in adults and children aged 10 years or older.
• Heart Failure: It is used to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults with heart failure with reduced ejection fraction. It can also reduce the risk of hospitalization for heart failure in adults with type 2 diabetes who have known cardiovascular disease or multiple cardiovascular risk factors.
• Chronic Kidney Disease (CKD): It is indicated to reduce the risk of worsening kidney disease, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease. It may also contribute to moderate weight loss and help lower blood pressure in some patients with type 2 diabetes.

Dosage and Administration

The usual recommended dose for adults and children aged 10 years and older is 10 mg once daily. It can be taken orally with or without food, preferably at the same time each day. For some indications or patient populations, a starting dose of 5 mg once daily may be considered. It's crucial to swallow the tablet whole with a glass of water and not to crush, chew, or break it. Patients should stay well-hydrated while taking this medicine.

Side Effects

Common side effects include:

• Urinary tract infections (UTIs)
• Genital fungal infections (vaginal yeast infections in women, yeast infections of the penis in men)
• Increased urination (frequent, urgent, or at night)
• Nausea, vomiting, or abdominal pain
• Stuffy or runny nose and sore throat (nasopharyngitis)
• Dizziness or lightheadedness, potentially due to dehydration or low blood pressure
• Back pain
• Mild skin rash

Serious side effects, though rare, can include:

• Diabetic ketoacidosis (increased ketones in blood or urine), especially in people with type 1 diabetes or during stress/illness
• Serious urinary tract infections that may lead to hospitalization
• Necrotizing fasciitis (a rare but serious bacterial infection in the genital or perineal area)
• Hypoglycemia (low blood sugar) when taken with other diabetes medications like insulin or sulfonylureas.

Precautions

• Allergies: Do not take if allergic to dapagliflozin or any other ingredients.
• Kidney/Liver Issues: Use with caution in patients with kidney or liver problems. Close monitoring is advised, and dosage adjustments may be necessary, particularly in elderly patients or those with reduced kidney function. It is generally not recommended for severe kidney disease or patients on dialysis.
• Dehydration: DAPALEX 10 MG Tablet can cause dehydration. Patients should drink plenty of fluids, especially during exercise or in hot weather, and report severe vomiting or diarrhea to their doctor.
• Pregnancy and Breastfeeding: Not recommended during the second and third trimesters of pregnancy due to potential risks to the fetus. It is also not recommended during breastfeeding.
• Alcohol: Avoid alcohol consumption as it may increase the risk of low blood sugar or dehydration.
• Surgery: Inform your doctor before any surgery, as they may advise temporarily stopping the medication due to the risk of diabetic ketoacidosis.
• Interactions: Inform your doctor about all medications, supplements, or herbal products being taken to avoid potential interactions, especially with diuretics, insulin, or sulfonylureas.

Storage

Store DAPALEX 10 MG Tablet in a cool, dry place at 15°C – 30°C or below 30°C. Keep it in its original packaging (blister pack/bottle) and protect from moisture, sunlight, and air exposure. Keep out of sight and reach of children and pets.

Here are some frequently asked questions about DAPALEX 10 MG TABLET (Dapagliflozin 10 mg):

What is DAPALEX 10 MG TABLET used for?

DAPALEX 10 MG TABLET, containing Dapagliflozin 10 mg, is a prescription medication primarily used to manage type 2 diabetes mellitus in adults and children aged 10 years or older when diet and exercise alone are not sufficient to control blood glucose levels. It is also prescribed for the management of heart failure and chronic kidney disease (reduced kidney function) in adults. Additionally, it may contribute to moderate weight loss in patients with type 2 diabetes.

How does DAPALEX 10 MG TABLET work?

DAPALEX 10 MG TABLET is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose in the kidneys, which leads to increased excretion of excess sugar (glucose), sodium, and water from the body through the urine. This process effectively lowers blood sugar levels and also helps reduce the workload on the heart and protect kidney function.

What is the usual dosage for DAPALEX 10 MG TABLET?

For adults and elderly patients, the standard dose is typically 10 mg once daily. It can be taken with or without food, usually at the same time each day. It is important to swallow the tablet whole with a glass of water and not to crush, chew, or break it. The exact dosage and duration will be determined by your doctor based on your condition and response to treatment.

What are the possible side effects of DAPALEX 10 MG TABLET?

Common side effects include genital fungal infections (like thrush), urinary tract infections (UTIs), increased urination frequency, back pain, dizziness, skin rash, dehydration, thirst, constipation, and dry mouth. Some individuals may also experience nausea or a stuffy/runny nose. If any side effects worsen or persist, it is advisable to contact your physician.

Is DAPALEX 10 MG TABLET safe during pregnancy or breastfeeding?

DAPALEX 10 MG TABLET is generally not recommended during pregnancy, especially during the second and third trimesters, as its safety has not been fully established and there's a potential risk to the fetus. Similarly, its use during breastfeeding is not advised as it is unknown if the medicine and/or its metabolites are excreted in human milk. Always consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Can DAPALEX 10 MG TABLET be taken with other medications?

DAPALEX 10 MG TABLET can be taken with other antidiabetic medications like metformin or insulin, but dosage adjustments may be necessary to avoid low blood sugar (hypoglycemia). Caution is advised when taken with diuretics (water pills) as it may increase the risk of low blood pressure. Inform your doctor about all medications you are taking, including herbal supplements like St. John's wort, to avoid potential interactions. Avoid consuming grapefruit juice within 24 hours of taking Dapalex, as it may affect the levels of dapagliflozin in your body.

What precautions should be taken while on DAPALEX 10 MG TABLET?

Before taking DAPALEX 10 MG TABLET, inform your doctor if you have any liver or kidney problems, severe low blood pressure, or are severely dehydrated due to excessive vomiting or diarrhea. It is not recommended for individuals with type 1 diabetes or diabetic ketoacidosis. Regular monitoring of blood sugar levels, kidney function, and hydration status is advised. Avoid excessive alcohol intake as it can affect blood sugar levels and increase the risk of dehydration.

What happens if a dose of DAPALEX 10 MG TABLET is missed?

If you miss a dose of DAPALEX 10 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may lead to low blood sugar or dehydration.

How should DAPALEX 10 MG TABLET be stored?

DAPALEX 10 MG TABLET should be stored at room temperature, ideally between 15°C and 30°C (or below 30°C), in a cool, dry place. Keep it in its original packaging (blister pack/bottle) and protect it from moisture, direct sunlight, and air exposure. Ensure it is kept out of sight and reach of children and pets. Properly dispose of expired or unused tablets.