Coligyl Dry Syr

COLIGYL DRY SYR by MANKIND PHARMA LTD: Detailed Product Description

COLIGYL DRY SYR is an antibiotic medication manufactured by Mankind Pharma Ltd, primarily used to manage bacterial infections in infants and children.

• Name: Coligyl Dry Syrup (Brand name)

• Composition: The active ingredient is Colistin (12.5 mg) or Colistin Sulphate (12.5mg). Colistin belongs to the group of polypeptide antibiotics.

• Uses: COLIGYL DRY SYR is prescribed for:

  • Bacterial infections of the gut (stomach and intestines) in infants and children.
  • Severe bacterial infections, particularly those unresponsive to other antibiotics.
  • Infections caused by gram-negative bacteria, including multidrug-resistant (MDR) infections.
  • Infectious diarrhea.
  • Bowel sterilization before surgery.
  • Controlling lung infections in children with cystic fibrosis (may also be used for this purpose).

• Dosage and Administration:

  • COLIGYL DRY SYRUP should be administered as advised by a physician.
  • Reconstitute the dry powder by mixing it with sterile water (provided with the package) or boiled, cooled water.
  • Close the bottle tightly and shake vigorously for at least 10-15 minutes until a uniform mixture is formed.
  • Measure the medicine using the provided measuring cup or spoon.
  • Shake the medicine well before each use.
  • The dose, quantity, and duration of therapy will be determined by the doctor based on the child's age, body weight, and severity of the infection.
  • It can be taken with or without food, but it is recommended to take it at the same time every day to maintain consistency.
  • Complete the full prescribed course, even if symptoms improve, to ensure all bacteria are killed and to prevent resistance or recurrence of the infection. Do not give a double dose to compensate for missed ones.

• Side Effects: Common side effects include:

  • Stomach upset, discomfort, or cramps.
  • Nausea or vomiting.
  • Diarrhea (may occur during or after treatment).
  • Fatigue or weakness.
  • Decreased appetite.
  • Skin rash or irritation.
  • Dizziness.

  Serious side effects (less common but require medical attention):

  • Kidney damage (can occur with severe cases).
  • Burning or tingling sensation of hands and feet.
  • Visual disturbances.
  • Severe difficulty in breathing.
  • Confusion.
  • Blood in urine and stools.

• Precautions:

  • Kidney Problems: Use with caution in children with kidney problems. The doctor may prescribe a low dose and monitor kidney functions closely.
  • Allergies: Do not administer if the child is allergic to colistin or other polymyxin antibiotics.
  • Blood/Muscle Disorders: Inform the doctor if the child has inherited blood or muscle disorders (e.g., myasthenia gravis) as it might increase muscle weakness.
  • Liver Disease: Use with caution in children with liver health issues.
  • Other Antibiotics: Avoid giving other antibiotics concomitantly without consulting a doctor, as it may potentiate effects and lead to unwanted side effects.
  • Diabetes: This medicine is sugar-based; caution is needed for diabetic patients.
  • Driving/Machines: May cause dizziness; restrict children from playing outdoors. (Note: Generally for children, not directly applicable but indicates potential central nervous system effects).
  • It is intended for use only in infants and children and is not suitable for use in pregnant or breastfeeding women.

• Storage:

  • Store at room temperature, not exceeding 30°C.
  • Keep in its original container, tightly closed.
  • Avoid direct sunlight, moisture, or high heat.
  • Keep out of the sight and reach of children.
  • Use the reconstituted medicine within 7 days of mixing.

COLIGYL DRY SYR is an antibiotic primarily used to treat bacterial infections in children. It contains Colistin Sulphate as its active ingredient.

Here are some frequently asked questions about COLIGYL DRY SYR:

What is COLIGYL DRY SYR used for?

COLIGYL DRY SYR is used to treat bacterial infections, particularly in the stomach, bowel, and intestines of children. It is effective against certain gram-negative bacteria, including those that are multidrug-resistant (MDR) and have not responded to other antibiotics. It may also be used for bowel sterilization before surgical procedures and to treat infectious diarrhea caused by specific bacteria like E. coli and Shigella.

How does COLIGYL DRY SYR work?

COLIGYL DRY SYR contains Colistin Sulphate, which is an antibiotic. It works by damaging the cell membranes of susceptible bacteria, which are vital for their survival. This disruption causes the bacterial cell contents to leak out, leading to the death of the bacteria and inhibiting their growth. It may also help to inactivate toxins produced by the bacteria.

What is the usual dosage of COLIGYL DRY SYR?

The dosage of COLIGYL DRY SYR is determined by a doctor based on the type and severity of the infection, as well as the child's condition. It is taken orally, and can be given with or without food. The dry powder needs to be reconstituted with sterile water (often provided) or boiled, cooled water before administration. It should be taken regularly at evenly spaced intervals as prescribed by your doctor.

What are the possible side effects of COLIGYL DRY SYR?

Common side effects can include nausea, vomiting, loss of appetite, stomach upset, diarrhea, skin rash, fatigue, and abdominal pain. More serious, but less common, side effects might involve kidney damage (nephrotoxicity) or neurotoxicity, which can manifest as numbness, tingling, confusion, dizziness, visual disturbances, or difficulty speaking. Most common side effects are temporary and usually resolve as the body adjusts to the medication. Consult your doctor if any side effects persist or worsen.

Is COLIGYL DRY SYR safe during pregnancy or breastfeeding?

COLIGYL DRY SYR is primarily intended for use in infants and children. For pregnant women, it should generally not be used unless absolutely necessary and after consulting a doctor to discuss potential benefits and risks. For breastfeeding women, caution is advised, and a doctor should be consulted before use.

Can COLIGYL DRY SYR be taken with other medications?

Yes, COLIGYL DRY SYR can interact with other medications. It's crucial to inform your doctor about all medicines your child is currently taking. Potential interactions include other antibiotics (like aminoglycosides, cephalosporins), antifungal medicines (e.g., Amphotericin B, which can increase the risk of kidney damage), neuromuscular blocking agents, cyclosporine, tacrolimus, vancomycin, streptomycin, and ethanol estradiol (oral contraceptives, which may become less effective). It should also not be taken within 14 days of a live cholera vaccine.

What precautions should be taken when using COLIGYL DRY SYR?

It is important to complete the full course of COLIGYL DRY SYR as prescribed by your doctor, even if symptoms improve, to ensure all bacteria are eliminated and to prevent the development of drug resistance. Inform your doctor if your child has known allergies to Colistin Sulphate or other antibiotics, or if they have kidney or liver problems, heart conditions, myasthenia gravis, or a history of colitis. For children with diabetes, consult your doctor as the syrup is sugar-based.

What happens if a dose of COLIGYL DRY SYR is missed?

If a dose of COLIGYL DRY SYR is missed, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to compensate for the missed one, as this can increase the risk of side effects.

How should COLIGYL DRY SYR be stored?

COLIGYL DRY SYR should be stored in a cool and dry place, away from direct sunlight, moisture, and high heat, ideally below 30°C. Keep it out of the sight and reach of children. Once the dry powder is reconstituted into a liquid suspension, it should be stored below 15°C and used within 7 days.

Is COLIGYL DRY SYR safe to use?

COLIGYL DRY SYR is generally considered safe when used exactly as prescribed by a doctor, following the recommended dosage and duration. It is crucial to adhere to your doctor's instructions and report any bothersome side effects immediately.