Depran- H Tablet

DEPRAN- H TABLET by INTAS PHARMACEUTICALS LTD

Name

• Brand Name: Depran-H Tablet
• Manufacturer: Intas Pharmaceuticals Ltd.

Composition

• DEPRAN- H TABLET contains a combination of two active ingredients: Clonazepam (0.25 mg) and Escitalopram (10 mg).
  • Clonazepam is a benzodiazepine that works by decreasing abnormal electrical activity in the brain, producing a calming effect and helping to control panic attacks and seizures.
  • Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain, improving mood, behavior, and cognition.

Uses DEPRAN- H TABLET is primarily prescribed for the treatment of various mental health conditions:

• Anxiety disorders
• Major Depressive Disorder (MDD)
• Panic attacks and panic disorders
• It can also be used to prevent and treat seizures (due to the Clonazepam component).

Dosage and Administration

• The typical dosage is one tablet daily, taken orally, with or without food.
• It is advised to take the medicine at the same time each day to maintain a consistent level in the body.
• Dosage and duration should be strictly as advised by a doctor, as it has habit-forming potential.
• Do not suddenly stop taking this medicine, as it can lead to withdrawal symptoms and recurrence of seizures.

Side Effects Common side effects may include:

• Drowsiness, dizziness, fatigue, sleepiness
• Nausea, vomiting, diarrhea, constipation
• Dry mouth
• Memory impairment, confusion
• Uncoordinated body movements (ataxia)
• Decreased libido (low sexual desire), delayed ejaculation, anorgasmia
• Weight gain or loss
• Irregular menstrual periods, rhinitis, cough, joint pain, muscle pain

Serious side effects to report immediately to a doctor include:

• Depression, suicidal tendencies or thoughts
• Convulsions (seizures)
• Fast heartbeat, decreased urine output

Precautions

• Age Restriction: Not recommended for use in patients below 18 years of age due to unestablished safety and efficacy.
• Medical Conditions: Use with caution in patients with a history of diabetes (risk of altered blood glucose levels), impaired kidney function, seizure disorders (increased risk of recurrent seizures), closed-angle glaucoma (may worsen condition), and respiratory disorders.
• Drug Interactions: Avoid concomitant use with alcohol. Carbamazepine, rifampin, and rifabutin may decrease the therapeutic effect of clonazepam.
• Activities: Avoid driving, operating machinery, or engaging in activities requiring high mental alertness, especially at the beginning of treatment, due to potential drowsiness and dizziness.
• Withdrawal: Do not stop the medication suddenly without consulting a doctor, as it can cause withdrawal symptoms.
• Drug Abuse: Use with caution in patients with a known history of drug abuse due to the high chance of dependency.
• Bleeding: May increase the risk of abnormal bleeding.

Storage

• Store the medicine in a cool and dry place.
• Keep it away from excess heat and moisture (not in the bathroom).
• Store below 30°C.
• Keep out of sight and reach of children.

What is DEPRAN-H TABLET used for?

DEPRAN-H TABLET is a prescription medicine primarily used to treat anxiety disorders and depression. It can also be used for the management of generalized anxiety disorder (GAD), panic disorder, and associated symptoms like excessive worry, restlessness, and sleep disturbances.

How does DEPRAN-H TABLET work?

DEPRAN-H TABLET is a combination of two medicines: Escitalopram and Clonazepam. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that works by increasing serotonin levels in the brain, which helps to improve mood, behavior, and cognition. Clonazepam is a benzodiazepine that increases the effect of gamma-aminobutyric acid (GABA), a chemical messenger that calms the brain by suppressing abnormal nerve cell activity. This combination provides both antidepressant and anxiolytic (anti-anxiety) effects.

What is the usual dosage for DEPRAN-H TABLET?

The dosage and duration of DEPRAN-H TABLET should be precisely as prescribed by your doctor, as it has the potential for habit-forming. It can be taken with or without food, but it is advised to take it at the same time each day to maintain a consistent level of medicine in the body. Do not crush, chew, or break the tablet; swallow it whole with a glass of water.

What are the possible side effects of DEPRAN-H TABLET?

Common side effects can include nausea, headache, dizziness, confusion, drowsiness, fatigue, sleeping problems, breathlessness, poor coordination of movements, stomach upset, decreased libido (low sexual desire), memory problems, delayed ejaculation, vomiting, diarrhea, dry mouth, increased or decreased appetite, and weight changes. If any of these side effects persist or worsen, consult your doctor.

Is DEPRAN-H TABLET safe during pregnancy or breastfeeding?

DEPRAN-H TABLET is not recommended for use during pregnancy as there is definite evidence of risk to the developing baby. It should be used with caution in breastfeeding mothers, and your doctor may advise you to stop breastfeeding while taking this medication as it may pass into breast milk and affect the nursing child.

Can DEPRAN-H TABLET be taken with other medications?

It is crucial to inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements, as many can interact with DEPRAN-H TABLET. For instance, avoid taking it with Monoamine Oxidase Inhibitors (MAOIs) or pimozide. Caution is also advised with certain anti-epileptic medicines, blood thinners, and other anti-anxiety or sedative medications. Avoid consuming grapefruit or grapefruit juice as it may interact with the medication.

What precautions should be taken while on DEPRAN-H TABLET?

Avoid consuming alcohol while taking DEPRAN-H TABLET, as it can increase sedative effects and the risk of other side effects like dizziness and drowsiness. This medicine may cause dizziness and drowsiness, so avoid driving or operating machinery until you know how it affects you. Inform your doctor if you have liver impairment, kidney disease, a history of substance abuse, seizure disorders, respiratory disorders, heart disease, or glaucoma. Patients, particularly young adults, should be monitored for suicidal thoughts, and any unusual changes in mood should be reported to a doctor immediately.

What happens if a dose of DEPRAN-H TABLET is missed?

If you miss a dose of DEPRAN-H TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How should DEPRAN-H TABLET be stored?

Store DEPRAN-H TABLET in a cool, dry place away from direct sunlight and moisture, and out of the sight and reach of children. It should be stored at room temperature, ideally between 10ºC to 25ºC or below 30ºC.