Numlo Tm 5

NUMLO TM 5 is a combination medication manufactured by EMCURE PHARMACEUTICALS LTD, primarily used for managing hypertension (high blood pressure).

Composition

NUMLO TM 5 contains two active ingredients:

• S-Amlodipine (5 mg): A calcium channel blocker that relaxes and widens blood vessels, improving blood flow.
• Telmisartan (40 mg): An angiotensin II receptor blocker that prevents blood vessels from narrowing.

Uses

NUMLO TM 5 is prescribed for:

• Treatment of hypertension (high blood pressure).
• Reducing the risk of cardiovascular events such as heart attack and stroke.
• Managing coronary artery disease and chest pain (angina).

Dosage and Administration

This medicine should be taken orally as directed by a physician. Swallow the tablet whole with a glass of water, with or without food, preferably at the same time each day to maintain consistent blood levels. Do not stop taking the medicine abruptly, even if you feel well, as this can worsen your condition.

Side Effects

Common side effects may include:

• Headache, dizziness, and sleepiness.
• Ankle swelling (edema), flushing (warmth in face/neck).
• Nausea, abdominal pain, fatigue, and increased potassium levels.

Serious side effects, though rare, can include severe chest pain, irregular heartbeat, allergic reactions (swelling of face or throat), or yellowing of the eyes/skin. Seek immediate medical attention if these occur.

Precautions

• Pregnancy and Breastfeeding: NUMLO TM 5 is unsafe during pregnancy and probably unsafe during breastfeeding. Consult your doctor.
• Alcohol: Avoid alcohol consumption as it may enhance the blood pressure-lowering effect and increase the risk of side effects.
• Driving: May cause dizziness or sleepiness; avoid driving or operating machinery until you know how it affects you.
• Medical Conditions: Use with caution in patients with liver disease, kidney disease, diabetes, very low blood pressure, or severe dehydration.
• Interactions: Inform your doctor about all other medications, especially other blood pressure-lowering drugs, potassium supplements, NSAIDs, and certain antibiotics, as interactions can occur. Avoid grapefruit or grapefruit juice.

Storage

Store NUMLO TM 5 below 25°C or at room temperature, away from light and moisture. Keep out of reach of children.

Here are some frequently asked questions about NUMLO TM 5:

What is NUMLO TM 5 used for?

NUMLO TM 5 is a combination medication primarily used to treat hypertension (high blood pressure) in adults. It helps reduce the risk of serious cardiovascular events such as heart attacks, strokes, and kidney problems associated with uncontrolled high blood pressure. It may also be prescribed to manage chest pain (angina) and other conditions related to coronary artery disease.

How does NUMLO TM 5 work?

NUMLO TM 5 contains two active ingredients: S-Amlodipine and Telmisartan. S-Amlodipine is a calcium channel blocker that works by relaxing and widening blood vessels, allowing blood to flow more smoothly. Telmisartan is an angiotensin II receptor blocker (ARB) that blocks the action of a hormone (angiotensin II) that causes blood vessels to narrow. By working together, these components relax and widen blood vessels, reducing the heart's workload and lowering blood pressure.

What is the usual dosage for NUMLO TM 5?

The typical dosage for NUMLO TM 5 is one tablet taken once daily. Each tablet usually contains S-Amlodipine 5 mg and Telmisartan 40 mg. Your doctor will determine the precise dose and duration of treatment based on your medical condition and response to the medication. It can be taken with or without food, but it is best to take it at the same time each day.

What are the possible side effects of NUMLO TM 5?

Common side effects may include dizziness, headache, nausea, fatigue, abdominal pain, stomach pain, constipation, double vision, muscle cramps, flushing (warmth and redness), and swelling of the ankles or feet (edema). Some serious but less common side effects can include severe chest pain, irregular heartbeat, allergic reactions (e.g., swelling of the face, lips, or throat), or yellowing of the eyes or skin (liver problems). If you experience any severe or persistent side effects, contact your doctor immediately.

Is NUMLO TM 5 safe during pregnancy or breastfeeding?

NUMLO TM 5 is generally not recommended during pregnancy, especially during the second and third trimesters, as Telmisartan (one of its components) can harm the unborn baby. If pregnancy is detected, treatment should be stopped immediately.

For breastfeeding mothers, caution is advised. While S-Amlodipine is considered to transfer minimally into breast milk with no reported adverse effects in infants, the safety of Telmisartan during breastfeeding is less clear, and the combination drug may not be safe. It is crucial to consult your doctor before taking this medicine if you are breastfeeding.

Can NUMLO TM 5 be taken with other medications?

NUMLO TM 5 can interact with several other medications. Inform your doctor about all prescription, over-the-counter, herbal, and supplement products you are taking. Significant interactions include:

• Other blood pressure-lowering medications: Can lead to excessively low blood pressure.
• Potassium supplements or salt substitutes: May increase potassium levels in the blood due to the Telmisartan component.
• Non-steroidal anti-inflammatory drugs (NSAIDs): Can reduce the blood pressure-lowering effect and potentially worsen kidney function.
• Lithium: Can increase lithium levels in the body, leading to toxicity.
• Simvastatin (a cholesterol-lowering medication): May increase the risk of muscle pain and weakness.
• Certain antibiotics (e.g., clarithromycin, erythromycin) and antifungals (e.g., ketoconazole, itraconazole): May increase S-Amlodipine levels, enhancing side effects.
• Grapefruit juice: Can increase S-Amlodipine levels in the body and should be avoided.

What precautions should be taken while using NUMLO TM 5?

Inform your doctor if you have liver or kidney problems, heart conditions (such as severe aortic stenosis or recent heart attack), diabetes, low blood pressure, or are dehydrated. Your doctor may need to monitor your blood pressure, kidney function, and electrolyte levels regularly. Alcohol consumption should be limited as it can increase the risk of dizziness and low blood pressure. Do not stop taking the medication abruptly without consulting your doctor, as this can worsen your condition.

What happens if a dose of NUMLO TM 5 is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose (typically more than 12 hours have passed since the missed dose), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should NUMLO TM 5 be stored?

NUMLO TM 5 should be stored at room temperature, typically between 20°C and 25°C (68°F and 77°F). Keep it in a dry place, protected from light and moisture, and in its original tightly closed container. Keep this medication out of the reach of children. Do not keep outdated medicine.