Penidure La 12 Inj

PENIDURE LA 12 INJ by WYETH

Name:

• Brand Name: Penidure LA 12 Injection
• Common Name: Benzathine Penicillin Injection I.P.

Composition: Each vial of Penidure LA 12 contains 1,200,000 units of Benzathine Penicillin I.P. as the active ingredient. It also includes Methyl Paraben I.P. and Propyl Paraben I.P. as preservatives, along with Sodium Citrate U.S.P. Anhydrous, Sodium Carboxymethyl Cellulose I.P., and Polyvinylpyrrolidone I.P. as buffering and suspending agents.

Uses: Penidure LA 12 Injection is an antibiotic used to treat and prevent a wide range of bacterial infections. It is effective against upper respiratory tract infections (like pharyngitis), skin infections (such as erysipelas), and sexually transmitted diseases including syphilis. This medication is also administered to prevent recurrent bacterial infections, notably rheumatic fever and bacterial endocarditis in individuals with pre-existing heart conditions.

Dosage and Administration: This medicine is administered by a qualified healthcare professional as a deep intramuscular injection, typically in the upper, outer quadrant of the buttock or the midlateral aspect of the thigh in neonates, infants, and small children. For streptococcal upper respiratory infections in adults, a single injection of 1,200,000 units is common. For primary, secondary, and latent syphilis, a single dose of 2,400,000 units is used. The full course of treatment must be completed even if symptoms improve, to prevent infection recurrence and antibiotic resistance.

Side Effects: Common side effects may include nausea, diarrhea, rash, allergic reactions, or pain, swelling, and redness at the injection site. Serious, though rare, hypersensitivity reactions, including anaphylactic shock, can occur.

Precautions: Inform your doctor about any known allergies, especially to penicillin. Caution is advised in patients with kidney disease, as dose adjustments or close monitoring may be required. Penidure LA 12 Injection should be used with caution during pregnancy and breastfeeding, only if clearly necessary, after consulting a doctor. It may reduce the effectiveness of oral contraceptives and should not be used concurrently with tetracycline. Driving or operating machinery is not recommended if side effects like blurred vision, confusion, or dizziness occur.

Storage: Penidure LA 12 Injection should be stored in a cool and dry place, away from sunlight, and out of reach of children and pets. The reconstituted suspension should not be used if discolored or if it contains particles.

PENIDURE LA 12 INJ by WYETH is a long-acting penicillin antibiotic used to treat and prevent various bacterial infections. It contains Benzathine Penicillin G, which works by targeting the bacterial cell wall.

What is PENIDURE LA 12 INJ used for?

PENIDURE LA 12 INJ is primarily used to treat a wide range of bacterial infections, including streptococcal upper respiratory infections (like pharyngitis), syphilis (primary, secondary, and latent), and tropical infectious skin diseases such as yaws or pinta. It is also commonly administered to prevent recurrent conditions like rheumatic fever and post-streptococcal glomerulonephritis.

How does PENIDURE LA 12 INJ work?

This medicine contains Benzathine Penicillin G, an antibiotic that functions by interfering with the formation of the bacterial cell wall. The bacterial cell wall is a crucial protective covering necessary for their survival. By damaging this wall, PENIDURE LA 12 INJ causes the bacteria to die, effectively clearing the infection. As a long-acting formulation, it is slowly released from the intramuscular injection site, providing prolonged antibacterial effects.

What is the usual dosage for PENIDURE LA 12 INJ?

PENIDURE LA 12 INJ is administered as a deep intramuscular injection by a healthcare professional. The specific dosage depends on the type and severity of the infection, as well as the patient's age and response to the medication. For instance, a single injection of 1,200,000 units is typically used for adult streptococcal upper respiratory infections, while prophylaxis for rheumatic fever often involves a monthly injection of 1,200,000 units. For syphilis (primary, secondary, and latent), a single dose of 2,400,000 units is common. It is crucial to follow your doctor's prescribed dosage and complete the entire course of treatment.

What are the possible side effects of PENIDURE LA 12 INJ?

Common side effects include fungal infections (candidiasis), diarrhea, nausea, and localized reactions at the injection site such as pain, swelling, and redness. More serious, but rare, side effects can include severe allergic reactions like rash, hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. If you experience any severe or persistent side effects, contact your doctor immediately.

Is PENIDURE LA 12 INJ safe during pregnancy or breastfeeding?

During pregnancy, PENIDURE LA 12 INJ is generally considered safe for use if clearly needed and prescribed by a doctor. For breastfeeding mothers, it is also considered safe, as human studies suggest the drug does not pass into breast milk in significant amounts that would be harmful to the baby. However, caution should be exercised, and consultation with a doctor is advised. Some sources suggest that breastfeeding can be resumed 24 hours after treatment completion.

Can PENIDURE LA 12 INJ be taken with other medications?

Concurrent use of PENIDURE LA 12 INJ with certain other medications may lead to interactions. For example, bacteriostatic antibiotics like tetracyclines may reduce the effectiveness of penicillin and should generally be avoided. Probenecid can increase and prolong the levels of penicillin in the blood. It may also reduce the effectiveness of oral contraceptives and increase the risk of bleeding when taken with anticoagulants (blood thinners). Always inform your doctor about all medications and supplements you are currently taking to prevent potential interactions.

What precautions should be taken when using PENIDURE LA 12 INJ?

It is crucial to inform your doctor about any allergies, especially to penicillin or other antibiotics, as PENIDURE LA 12 INJ can cause severe allergic reactions. The injection must be given deep intramuscularly only and should never be injected intravenously, intra-arterially, or near nerves or blood vessels, as this can cause damage. Patients with kidney or liver problems, or a history of asthma, should use this medicine with caution, and dose adjustments may be necessary for kidney impairment. It is vital to complete the full course of treatment as prescribed, even if symptoms improve, to ensure the infection is fully eradicated and to prevent the development of antibiotic-resistant bacteria. Driving or operating machinery should be avoided if you experience side effects that affect your concentration or coordination. If the solution appears discolored or contains particles, it should not be used.

What happens if a dose of PENIDURE LA 12 INJ is missed?

As PENIDURE LA 12 INJ is administered by a qualified healthcare professional, the likelihood of missing a dose is very low. If a scheduled dose is missed, it is important to inform your doctor or nurse immediately for further instructions. Do not attempt to self-administer or double your dose without medical guidance.

How should PENIDURE LA 12 INJ be stored?

PENIDURE LA 12 INJ should be stored in a cool and dry place, away from direct sunlight and moisture, typically below 25°C or 30°C. It must be kept out of the sight and reach of children.