Empagreat M 1000mg Tab

EMPAGREAT M 1000MG TABLET

EMPAGREAT M 1000MG TABLET is a prescription medicine manufactured by Mankind Pharma Ltd.

• Name

  • Brand Name: EMPAGREAT M 1000MG TAB
  • Common Name: Empagliflozin and Metformin Hydrochloride

• Composition EMPAGREAT M 1000MG TABLET contains a combination of two active ingredients:

  • Empagliflozin (typically 12.5 mg for the 1000mg metformin variant)
  • Metformin Hydrochloride (1000 mg)

• Uses EMPAGREAT M 1000MG TABLET is used in adults, alongside diet and exercise, to manage high blood sugar levels in individuals with Type 2 Diabetes Mellitus. It is also indicated to:

  • Reduce the risk of cardiovascular death in adults with Type 2 Diabetes and established cardiovascular disease.
  • Lower the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure.
  • Reduce the risk of worsening kidney disease, end-stage kidney disease, cardiovascular death, and hospitalization in adults with chronic kidney disease. This medication does not treat Type 1 Diabetes.

• Dosage and Administration The dosage should be individualized based on the patient's current treatment regimen, tolerability, and response. It is typically taken twice daily with meals to minimize gastrointestinal side effects associated with metformin. Tablets should be swallowed whole and not chewed. The maximum recommended daily dose usually does not exceed 25 mg of empagliflozin and 2000 mg of metformin.

• Side Effects

  • Common Side Effects: Low blood sugar (hypoglycemia), urinary tract infections, increased urination, genital yeast infections (in both men and women), headache, diarrhea, nausea, vomiting, gas, abdominal discomfort, indigestion, weakness, and joint pain.
  • Serious Side Effects (Seek immediate medical attention): Lactic acidosis (symptoms include confusion, fast breathing, severe stomach pain, muscle pain, unusual sleepiness), diabetic ketoacidosis (high ketones and acid in the blood, can be life-threatening), severe allergic reactions (rash, swelling of face/throat, difficulty breathing), sudden kidney problems, low blood pressure, and serious genital infection (Fournier's gangrene). A rare risk of lower leg, foot, or toe amputation has also been noted.

• Precautions EMPAGREAT M 1000MG TABLET is contraindicated in individuals with allergies to its components, metabolic acidosis (lactic acidosis, diabetic ketoacidosis), diabetic pre-coma, severe kidney or liver impairment (eGFR <30 mL/min/1.73 m²), conditions affecting the kidneys (like severe infection or dehydration), or during intravascular administration of iodinated contrast agents.

  • The risk of lactic acidosis increases with kidney or liver problems, excessive alcohol intake, dehydration, and certain medical procedures.
  • It may cause dehydration, particularly in elderly patients or those taking diuretics.
  • Close monitoring for hypoglycemia is necessary if taken with insulin or sulfonylureas.
  • It should be temporarily discontinued before major surgery or procedures requiring fasting.
  • Avoid excessive alcohol consumption while on this medication.
  • Interactions can occur with diuretics, insulin/sulfonylureas, and NSAIDs.

• Storage Store at a controlled room temperature, typically around 25°C (77°F), with excursions permitted between 15-30°C (59-86°F). Keep the medication in a dry place, away from light and moisture, and out of reach of children and pets.

Here are the most frequently asked questions about EMPAGREAT M 1000MG TAB, along with their answers:

What is EMPAGREAT M 1000MG TAB used for?

EMPAGREAT M 1000MG TAB is primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus, alongside diet and exercise. It also helps in improving glycemic control, reducing the risk of cardiovascular death and hospitalisation for heart failure in diabetic patients, and can offer benefits in weight management and renal protection.

How does EMPAGREAT M 1000MG TAB work?

This medicine contains two active ingredients: Empagliflozin and Metformin. Empagliflozin works by blocking a protein in the kidneys called SGLT2, which leads to the removal of excess sugar from the body through urine. Metformin reduces the production of glucose in the liver, enhances the body's sensitivity to insulin, and decreases the absorption of glucose from the intestines. Together, they work to lower blood glucose more effectively.

What is the usual dosage for EMPAGREAT M 1000MG TAB?

The dosage of EMPAGREAT M 1000MG TAB is determined by your doctor, based on your kidney function and how your body responds to the medication. It should be taken orally, typically with food, at the same time each day for best results. It's crucial not to exceed the prescribed dose, which is generally not more than 25 mg of empagliflozin and 2000 mg of metformin per day.

What are the possible side effects of EMPAGREAT M 1000MG TAB?

Common side effects can include nausea, diarrhoea, abdominal discomfort, increased urination frequency, and vaginal or genital yeast infections. Less common but more serious side effects may include dehydration, low blood sugar (hypoglycemia), and rarely, lactic acidosis or diabetic ketoacidosis.

Is EMPAGREAT M 1000MG TAB safe during pregnancy or breastfeeding?

EMPAGREAT M 1000MG TAB is generally not recommended during pregnancy, especially in the second and third trimesters, due to limited information and potential harmful effects. It may also be unsafe during breastfeeding as it can pass into breast milk. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can EMPAGREAT M 1000MG TAB be taken with other medications?

Yes, but caution is advised as it can interact with certain medications. Inform your doctor about all medicines, supplements, or herbal products you are taking. For example, diuretics may increase the risk of dehydration, while insulin and sulfonylureas could increase the risk of low blood sugar. NSAIDs and ACE inhibitors can also affect kidney function when taken with this medicine.

What precautions should be taken while using EMPAGREAT M 1000MG TAB?

Avoid alcohol while taking this medicine as it can increase the risk of a serious side effect called lactic acidosis. Inform your doctor if you have kidney or liver problems, heart conditions, severe infections, or are prone to dehydration. It is not recommended for individuals with type 1 diabetes. Regular monitoring of blood sugar levels is important.

What happens if a dose of EMPAGREAT M 1000MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to compensate for a missed one.

How should EMPAGREAT M 1000MG TAB be stored?

EMPAGREAT M 1000MG TAB should be stored in a cool and dry place, away from direct sunlight.