Perinorm 60ml

PERINORM 60ML Syrup

• Name: Perinorm Syrup. The common name for the active ingredient is Metoclopramide.
• Composition: Each 60ml bottle of Perinorm Syrup contains Metoclopramide (5mg per ml).
• Uses: Perinorm Syrup is a prokinetic and anti-emetic medicine primarily used to relieve symptoms such as nausea, vomiting, indigestion, and heartburn. It is also prescribed for Gastroesophageal Reflux Disease (GERD), gastroparesis (including diabetic gastroparesis), and to manage delayed nausea and vomiting associated with chemotherapy and radiotherapy in adults and children (aged 1-18 years). Additionally, it can alleviate nausea and vomiting that may occur with migraines.
• Dosage and Administration: The typical adult dosage is 10-20 ml, taken three times a day before meals. It is recommended to take the syrup on an empty stomach, preferably at bedtime, as advised by a healthcare provider. Use a measuring cup or spoon for accurate dosing. Shake the bottle well before each use.
• Side Effects:
  • Common: Restlessness, fatigue, weakness, drowsiness, headache, and diarrhea.
  • Serious/Rare: Uncontrollable movements (e.g., shaking, tics, muscle stiffness or rigidity, tardive dyskinesia), breast enlargement in men, confusion, hallucinations, and heart problems (particularly with overdose).
• Precautions:
  • Avoid consuming alcohol as it can enhance drowsiness.
  • Do not drive or operate machinery if experiencing dizziness, drowsiness, or uncontrolled movements.
  • Inform your doctor about any existing liver or kidney problems.
  • Not recommended for patients with epilepsy, Parkinson's disease, gastrointestinal bleeding/obstruction/perforation, or adrenal gland tumors (pheochromocytoma).
  • Pregnancy and Breastfeeding: Consult a doctor. Generally considered safe during pregnancy if prescribed, but not recommended during breastfeeding as it may pass into breast milk.
  • Children: Not recommended for infants under 1 year of age due to increased risk of uncontrollable movements. Use with caution in children and adolescents (1-18 years) for specific indications.
• Storage: Store Perinorm Syrup in a cool, dry place below 25°C or 30°C, away from direct sunlight. Keep out of the sight and reach of children.

Perinorm 60ml by IPCA Laboratories Ltd. is a medication containing Metoclopramide, primarily used to treat various gastrointestinal issues. Below are frequently asked questions about this medicine.

What is Perinorm Syrup used for?

Perinorm Syrup is primarily used to relieve symptoms such as nausea, vomiting, indigestion, and heartburn. It can also manage conditions like Gastroesophageal Reflux Disease (GERD) and gastroparesis (delayed stomach emptying), including diabetic gastroparesis. Additionally, it helps prevent delayed nausea and vomiting after chemotherapy or radiotherapy, and manages nausea and vomiting associated with migraines. It can also be used post-surgery to relieve nausea and vomiting.

How does Perinorm Syrup work?

Perinorm Syrup contains Metoclopramide, which acts as a prokinetic and anti-emetic agent. It works by increasing the movement (motility) of the stomach and intestines, helping food move more quickly through the digestive system. It also blocks dopamine D2 and serotonin 5-HT3 receptors in the brain's chemoreceptor trigger zone (CTZ) and the vomiting center, thereby reducing the sensation of nausea and preventing vomiting.

What is the usual dosage of Perinorm Syrup?

The dosage of Perinorm Syrup varies depending on the patient's condition, age, body weight, and response to treatment. For adults, a common recommendation is 10-20 ml three times a day before meals. It is typically taken orally 30 minutes before meals and at bedtime. It is crucial to follow the dosage and duration prescribed by your doctor and use the provided measuring cup or spoon for accuracy.

What are the possible side effects of Perinorm Syrup?

Common side effects of Perinorm Syrup may include drowsiness, restlessness, fatigue, headache, dizziness, and diarrhea. More serious, though less common, side effects can include uncontrollable body movements, muscle stiffness or rigidity, and tardive dyskinesia, which are abnormal muscle movements that may not go away even after stopping the medicine.

Is Perinorm Syrup safe during pregnancy or breastfeeding?

Perinorm Syrup should be used with caution during pregnancy and only if clearly advised by a doctor. Animal studies have shown low or no adverse effects, but human studies are limited. It is generally not recommended for use during breastfeeding as Metoclopramide can pass into breast milk and may affect the baby. Consulting a doctor is essential to weigh the potential risks and benefits.

Can Perinorm Syrup be taken with other medications?

Perinorm Syrup can interact with various medications. Inform your doctor about all other medicines you are taking.

• Antidepressants: Such as fluoxetine and paroxetine, can increase the risk of side effects.
• Antipsychotics: Like haloperidol and risperidone, may lead to increased sedation and movement disorders.
• Opioids: Such as codeine and tramadol, can have enhanced sedative effects.
• Sedatives: Like diazepam and lorazepam, may cause increased drowsiness.
• Parkinson's disease medications: Such as levodopa, carbidopa, entacapone, and tolcapone, can interact.
• Other interactions: Include anticholinergics, digoxin, ciclosporin, mivacurium, and suxamethonium.

What precautions should be taken while using Perinorm Syrup?

• Alcohol: Avoid consuming alcohol as it can increase drowsiness and dizziness.
• Driving & Operating Machinery: Do not drive or operate heavy machinery if you experience drowsiness, dizziness, or uncontrollable movements.
• Underlying Conditions: Inform your doctor if you have liver or kidney problems, Parkinson's disease, epilepsy, heart problems, or a history of depression, gastrointestinal bleeding, obstruction, or tear.
• Duration of Use: Long-term use (more than 12 weeks) should generally be avoided due to the increased risk of tardive dyskinesia.

What happens if a dose of Perinorm Syrup is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Perinorm Syrup be stored?

Store Perinorm Syrup at room temperature, below 30°C, and away from heat and moisture. Keep it out of the sight and reach of children. Do not use the medicine beyond its expiry date.