Daparyl Vm 500 Tablet

DAPARYL VM 500 TABLET

DAPARYL VM 500 TABLET is a medication manufactured by Intas Pharmaceuticals Ltd, prescribed for the management of Type 2 Diabetes Mellitus.

• Composition: Each tablet contains a combination of three active antidiabetic agents:

  • Dapagliflozin (10 mg)
  • Vildagliptin (100 mg)
  • Metformin (500 mg) These ingredients work synergistically to lower blood sugar levels. Dapagliflozin helps remove excess sugar from the body via urine by inhibiting SGLT2 in the kidneys. Vildagliptin enhances glucose-mediated insulin secretion and reduces glucose production by the liver. Metformin decreases glucose production in the liver, reduces intestinal glucose absorption, and improves the body's sensitivity to insulin.

• Uses: DAPARYL VM 500 TABLET is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It helps control high blood sugar levels, reduces HbA1c, and can support weight loss. Managing blood glucose levels is crucial to reduce the risk of long-term complications associated with diabetes, such as kidney damage, eye damage, nerve problems, and cardiovascular disease.

• Dosage and Administration: This medicine should be taken orally exactly as prescribed by your doctor. It is typically recommended to take the tablet with food to minimize gastrointestinal side effects like nausea, vomiting, or diarrhea. Swallow the tablet whole; do not crush, break, or chew it. Consistency is important, so try to take it at the same time each day. Do not alter the dosage or discontinue the medication without consulting your healthcare provider.

• Side Effects:

  • Common Side Effects: Vomiting, nausea, abdominal pain, headache, frequent urination, painful urination, allergic reactions, vaginal yeast infection, nasopharyngitis, urinary tract infection, diarrhea, dizziness, increased thirst, and inflammation of the penis (in men).
  • Serious Side Effects: Lactic acidosis can occur due to metformin accumulation, with increased risk in patients with hepatic or renal insufficiency. Severe allergic reactions (anaphylaxis), liver problems (e.g., jaundice), kidney problems, blood disorders, seizures, confusion, and hallucinations are rare but possible. If side effects persist, worsen, or severe symptoms occur (e.g., fever, chills, burning urination, swelling of face/tongue/throat, difficulty swallowing, hives, breathing problems), seek immediate medical attention.

• Precautions:

  • Allergies: Avoid if allergic to Dapagliflozin, Vildagliptin, Metformin, or any components.
  • Pregnancy and Breastfeeding: Not recommended for pregnant or breastfeeding women.
  • Alcohol: Avoid alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
  • Kidney/Liver Disease: Use with caution in patients with kidney problems, and it is probably unsafe in patients with liver disease. Regular monitoring of kidney function may be necessary.
  • Other Conditions: Not recommended for Type 1 diabetes, diabetic ketoacidosis, acute or chronic metabolic acidosis, history of lactic acidosis, or severe dehydration. Inform your doctor about heart problems, hypertension, or vitamin B12/folic acid deficiency.
  • Drug Interactions: Inform your doctor about all medications, including other diabetic medications (e.g., insulin), diuretics, birth control pills, thyroid medicines, corticosteroids, anti-epileptics, anti-lipemics, anti-tuberculars, cardiovascular agents, and antimalarials.
  • Children and Elderly: Not recommended for use in children below 18 years. Elderly patients may require dosage adjustments due to increased sensitivity to side effects.
  • Driving: May cause dizziness; exercise caution and avoid driving or operating machinery if affected.

• Storage: Store in a cool and dry place, away from direct sunlight and moisture. Keep out of the sight and reach of children. Store below 30°C.

DAPARYL VM 500 TABLET is a combination medication used to manage type 2 diabetes mellitus. It contains Dapagliflozin, Vildagliptin, and Metformin, which work together to help control blood sugar levels.

What is DAPARYL VM 500 TABLET used for?

DAPARYL VM 500 TABLET is used in adults with type 2 diabetes mellitus to control high blood sugar levels. It is prescribed as an adjunct to diet and exercise to improve glycemic control and reduce the risk of diabetes-related complications such as kidney damage, eye damage, and nerve problems.

How does DAPARYL VM 500 TABLET work?

This medication combines three active ingredients that work through different mechanisms:

• Dapagliflozin (a sodium-glucose cotransporter-2 inhibitor or SGLT2 inhibitor) helps the kidneys remove excess sugar from the body through urine.
• Vildagliptin (a dipeptidyl peptidase-4 inhibitor) increases the release of insulin and signals the liver to stop producing sugar when blood sugar levels are high.
• Metformin (a biguanide) reduces glucose production in the liver, decreases sugar absorption from the intestines, and improves the body's sensitivity to insulin, allowing cells to use glucose more effectively.

What is the usual dosage for DAPARYL VM 500 TABLET?

The dosage of DAPARYL VM 500 TABLET is determined by your doctor based on your age, body weight, and medical condition. It is typically taken orally with meals to minimize gastrointestinal side effects. You should always follow your healthcare provider's instructions and not alter the dosage or frequency without consultation.

What are the possible side effects of DAPARYL VM 500 TABLET?

Common side effects can include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, abdominal pain, headache, frequent urination, and genital mycotic (yeast) infections. Less common side effects may include dizziness, increased thirst, skin rash, and painful urination. If you experience severe or persistent side effects, or symptoms like fever, chills, back pain, or difficulty breathing, seek immediate medical attention.

Is DAPARYL VM 500 TABLET safe during pregnancy or breastfeeding?

DAPARYL VM 500 TABLET is generally not recommended during pregnancy as it may not be suitable and limited studies have shown potential harmful effects on the developing baby in animal studies. It is also advisable to consult your doctor before using this medication while breastfeeding, as some components may pass into breast milk and could potentially harm the baby.

Can DAPARYL VM 500 TABLET be taken with other medications?

DAPARYL VM 500 TABLET can interact with several other medications, including other diabetic medications (like insulin), water pills (diuretics), birth control pills, thyroid medicines, corticosteroids, anti-epileptics, and certain cardiovascular agents. It's crucial to inform your doctor about all prescription and over-the-counter medicines, supplements, and herbal products you are taking to avoid potential drug interactions.

What precautions should be taken with DAPARYL VM 500 TABLET?

Inform your doctor if you have kidney or liver problems, heart conditions, a history of urinary tract infections, or a vitamin B12 deficiency. Avoid or limit alcohol consumption while taking this medicine as it can affect blood sugar control and increase the risk of side effects like lactic acidosis. Regular monitoring of blood sugar levels is essential. If you experience dizziness or drowsiness, avoid driving or operating machinery.

What happens if a dose of DAPARYL VM 500 TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should DAPARYL VM 500 TABLET be stored?

DAPARYL VM 500 TABLET should be stored in a cool, dry place away from direct sunlight and moisture. Keep it out of the sight and reach of children, and do not use the medication beyond its expiration date.