Trivedon Mr Tablet

TRIVEDON MR TABLET

TRIVEDON MR Tablet, manufactured by Cipla Health Ltd, is an anti-anginal medication primarily used for the management of stable angina pectoris. It is a modified-release formulation designed to provide sustained action.

• Name:

  • Brand Name: TRIVEDON MR TABLET
  • Common Name: Trimetazidine (modified release)

• Composition:

  • Each tablet contains Trimetazidine 35 mg.

• Uses: TRIVEDON MR is indicated in adults as an add-on therapy for the symptomatic treatment of patients with stable angina pectoris (chest pain caused by reduced blood flow to the heart) who are inadequately controlled by or intolerant to first-line anti-anginal therapies. It works by optimizing the heart's energy metabolism, shifting it from fatty acid oxidation to glucose oxidation, which requires less oxygen consumption. This helps to protect heart cells during periods of reduced oxygen supply, thereby reducing the frequency and severity of angina attacks and improving exercise tolerance. Some sources also mention its use for vertigo, tinnitus, and visual disturbances, although angina pectoris is its primary indication.

• Dosage and Administration: The typical dose is one TRIVEDON MR tablet twice daily, taken once in the morning and once in the evening, during meals. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. The benefit of the treatment should be assessed after three months, and trimetazidine should be discontinued if there is no treatment response. For patients with moderate renal impairment (creatinine clearance 30-60 ml/min), the recommended dose is one TRIVEDON MR tablet in the morning during breakfast.

• Side Effects: Common side effects may include:

  • Dizziness
  • Headache
  • Abdominal pain
  • Diarrhea
  • Nausea and vomiting
  • Indigestion/Dyspepsia
  • Rash, pruritus (itching), urticaria (hives)
  • Asthenia (feeling of weakness/fatigue) Serious, though rare, side effects can include Parkinsonian symptoms (tremor, akinesia, hypertonia, gait instability), restless leg syndrome, and other related movement disorders, which are usually reversible upon treatment discontinuation.

• Precautions:

  • TRIVEDON MR is not recommended for use in patients with Parkinson's disease, Parkinsonian symptoms, restless leg syndrome, or severe kidney problems.
  • It is not meant for treating sudden chest pain (acute angina attacks) or unstable angina or a heart attack.
  • Use with caution in elderly patients (above 75 years) due to increased trimetazidine exposure and risk of side effects.
  • Pregnant and breastfeeding women should consult their doctor, as its use is generally not recommended or requires careful monitoring.
  • Avoid driving or operating machinery if you experience dizziness, drowsiness, or blurred vision after taking this medicine.
  • Caution is advised in patients with liver disease.
  • Alcohol consumption may increase dizziness.
  • Safety and efficacy in children below 18 years have not been established.

• Storage: Store TRIVEDON MR Tablet in a cool and dry place, ideally below 30°C. Keep it away from direct sunlight, heat, moisture, and out of the sight and reach of children and pets to maintain its efficacy.

TRIVEDON MR TABLET by CIPLA HEALTH LTD contains Trimetazidine Dihydrochloride as its active ingredient. This is a modified-release (MR) tablet.

What is TRIVEDON MR TABLET used for?

TRIVEDON MR TABLET is primarily used in adults as an add-on therapy for the symptomatic treatment of stable angina pectoris, which is chest pain caused by reduced blood flow and oxygen supply to the heart. It is prescribed for patients who are not adequately controlled by or are intolerant to first-line antianginal therapies. It helps to reduce the frequency and severity of angina attacks, improving the patient's quality of life.

How does TRIVEDON MR TABLET work?

TRIVEDON MR TABLET contains Trimetazidine, which acts as a metabolic agent. It works by inhibiting the β-oxidation of fatty acids, which in turn enhances glucose oxidation. In ischemic conditions (reduced oxygen supply), glucose oxidation requires less oxygen to produce the same amount of energy (ATP) compared to fatty acid oxidation. This metabolic shift optimizes cellular energy processes, helps maintain intracellular ATP levels, and protects heart muscle cells from the effects of reduced oxygen supply, without significantly affecting heart rate or blood pressure.

What is the usual dosage of TRIVEDON MR TABLET?

The usual recommended dose for TRIVEDON MR (modified-release 35 mg tablet) is one tablet taken twice daily, typically once in the morning and once in the evening, with meals. For patients with moderate renal impairment (creatinine clearance 30-60 ml/min), the recommended dose is one 35 mg tablet in the morning during breakfast. It's important to swallow the tablet whole and not to chew or crush it, as this can affect its modified-release properties.

What are the possible side effects of TRIVEDON MR TABLET?

Common side effects include dizziness, headache, abdominal pain, diarrhea, indigestion, nausea, vomiting, rash, itching, hives, and a feeling of weakness. Rare but serious side effects can include new-onset or worsening of parkinsonian symptoms (such as tremors, unsteady gait, muscle stiffness, or uncontrollable body movements), palpitations, extrasystoles, tachycardia, arterial hypotension, orthostatic hypotension (a fall in blood pressure upon standing), and flushing. If you experience any severe or persistent side effects, you should consult your doctor.

Is TRIVEDON MR TABLET safe during pregnancy or breastfeeding?

TRIVEDON MR TABLET is generally not recommended during pregnancy. It is preferable to avoid its use as there is a lack of sufficient clinical data on its use in pregnant women, and animal studies have not shown teratogenicity. During breastfeeding, it is also not recommended as it is unknown whether trimetazidine is excreted in human milk, and a risk to newborns/infants cannot be excluded. Always consult your doctor if you are pregnant or breastfeeding before taking this medication.

Can TRIVEDON MR TABLET be taken with other medications?

No specific drug interactions have been widely reported with Trimetazidine, particularly with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic agents, or digitalis preparations. However, caution is advised when taking it with sedatives, hypnotics (like buspirone), strong painkillers, certain allergy medications (like chlorphenamine), some antidepressants (e.g., fluoxetine, lithium), blood pressure-lowering medications (e.g., methyldopa), drugs for Parkinson's disease (e.g., levodopa, pramipexole, ropinirole), and epilepsy medications (e.g., phenobarbital, carbamazepine, phenytoin). It's crucial to inform your doctor about all medications, supplements, and herbal remedies you are currently taking to avoid potential interactions.

What precautions should be taken?

Do not take TRIVEDON MR TABLET if you are allergic to trimetazidine or any of its components, or if you have Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome, other related movement disorders, or severe renal impairment (creatinine clearance less than 30 ml/min). TRIVEDON MR TABLET is not for the curative treatment of angina attacks, nor for initial treatment of unstable angina pectoris or myocardial infarction. It may cause dizziness or drowsiness, so exercise caution when driving or operating machinery if affected. Regular monitoring of renal function is recommended.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should it be stored?

TRIVEDON MR TABLET should be stored in a cool and dry place, away from direct sunlight, and kept out of the sight and reach of children. Do not use the medicine after the expiry date.