Dapaglyn S 10/100 Mg Tablet (10 Tab)

DAPAGLYN S 10/100 MG TABLET is a prescription medicine manufactured by ZYDUS HEALTHCARE LIMITED, used for the management of type 2 diabetes mellitus.

Name

Brand Name: Dapaglyn S 10/100 MG Tablet Common Name: Dapagliflozin and Sitagliptin Tablets

Composition

Each tablet contains:

• Dapagliflozin: 10 mg
• Sitagliptin: 100 mg

Uses

Dapaglyn S 10/100 MG Tablet is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by diet and exercise alone, or in conjunction with other diabetes medications such as metformin, sulphonylureas, or insulin. This medication works to lower elevated blood glucose levels and helps prevent serious complications of diabetes like eyesight loss (retinopathy), kidney damage (nephropathy), nerve damage (neuropathy), and diabetic foot ulcer. Additionally, it may be used to treat chronic kidney disease in adults with reduced kidney function and can reduce the risk of cardiovascular events, heart attack, and heart failure in certain diabetic patients.

Dosage and Administration

The dosage of Dapaglyn S 10/100 MG Tablet should be taken exactly as guided by your doctor. It can be taken with or without food, but it is recommended to take it at the same time each day for optimal benefits and consistency. The tablet should be swallowed whole with a glass of water and not crushed or chewed. Do not stop taking this medicine without consulting your doctor, as abrupt discontinuation can lead to increased blood sugar levels and potential complications.

Side Effects

Common side effects of Dapaglyn S 10/100 MG Tablet may include:

• Common cold, nasal congestion, sore throat (nasopharyngitis)
• Headaches
• Back pain, joint pain
• Diarrhoea, nausea
• Urinary tract infections (UTIs)
• Genital fungal infections (in both males and females)
• Frequent urination, dizziness, or light-headedness
• Hypoglycemia (low blood sugar), especially when used with other anti-diabetic medicines

Serious side effects, though less common, can include:

• Diabetic ketoacidosis (symptoms like nausea, vomiting, abdominal pain, excessive thirst, rapid breathing)
• Allergic reactions (rash, hives, swelling of face, lips, tongue, or throat)
• Pancreatitis (severe and persistent stomach pain)
• Necrotizing fasciitis of the perineum (Fournier's gangrene)

Precautions

• Allergies: Do not take Dapaglyn S 10/100 MG Tablet if you are allergic to dapagliflozin, sitagliptin, or any other ingredients of the tablet.
• Pregnancy and Breastfeeding: Dapagliflozin is contraindicated during the second and third trimesters of pregnancy. The use of this medicine is not advised while breastfeeding as it may pass into breast milk. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Kidney and Liver Disease: Use with caution in patients with kidney or liver impairment. It is contraindicated in individuals with severe kidney impairment, end-stage renal disease, or those on dialysis.
• Alcohol: Alcohol can interfere with the effectiveness of this medicine and affect blood sugar levels.
• Dehydration: The medication can increase urination and may lead to dehydration. Drink plenty of fluids to stay hydrated.
• Drug Interactions: Inform your doctor about all other medications you are taking, including over-the-counter drugs, supplements, and herbal remedies. Interactions can occur with diuretics (e.g., furosemide), insulin, or insulin secretagogues (e.g., sulfonylureas), potentially increasing the risk of low blood sugar or dehydration.
• Other Conditions: Caution is advised for patients with a history of pancreatitis, gallstones, heart failure, type 1 diabetes, or diabetic ketoacidosis.
• Children: Dapaglyn S 10/100 MG Tablet is not recommended for use in children under 18 years of age.

Storage

Store Dapaglyn S 10/100 MG Tablet at room temperature, ideally below 30°C. Keep the product in its original packaging to protect it from light and moisture. Keep out of reach of children and pets.

1. What is Dapaglyn S 10/100 MG Tablet used for?

Dapaglyn S 10/100 MG Tablet is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by diet and exercise alone, or by metformin alone. This medicine helps improve blood sugar control and can also reduce the risk of serious complications like kidney damage and blindness. It may also offer cardiovascular and renal benefits, including reducing the risk of heart attack, heart failure, or other cardiovascular events.

2. How does Dapaglyn S 10/100 MG Tablet work?

Dapaglyn S 10/100 MG Tablet contains two active ingredients: Dapagliflozin (10 mg) and Sitagliptin (100 mg).

• Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor. It works by blocking a protein in the kidneys responsible for reabsorbing glucose (sugar) back into the blood from the urine. This leads to the removal of excess sugar from the body through urine, thereby lowering blood sugar levels.
• Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It indirectly increases the activity of natural substances called incretins, which stimulate the pancreas to produce more insulin when blood glucose levels are high. It also decreases the production of glucagon (a hormone that raises blood sugar) by the liver.

Together, these two components work through different mechanisms to effectively lower and control blood glucose levels.

3. What is the usual dosage for Dapaglyn S 10/100 MG Tablet?

The dosage of Dapaglyn S 10/100 MG Tablet is determined by your doctor, based on your medical condition and response to treatment. It is typically taken orally, usually once daily, and can be taken with or without food. It is recommended to take it at the same time each day for optimal benefits. You should always adhere to the prescribed dosage and never exceed it without consulting your doctor.

4. What are the possible side effects of Dapaglyn S 10/100 MG Tablet?

Common side effects may include:

• Urinary tract infections (UTIs)
• Genital fungal infections (vaginal or penile yeast infections)
• Nasal congestion or sore throat (nasopharyngitis)
• Headache
• Dizziness or lightheadedness
• Increased urination or thirst
• Nausea and vomiting
• Diarrhea
• Back pain, joint pain

Some individuals may experience hypoglycemia (low blood sugar) when this medicine is used with other anti-diabetic medications, alcohol, or if a meal is delayed or missed. Serious but rare side effects can include inflamed pancreas or severe allergic reactions. If you experience persistent or worsening side effects, or any serious symptoms, consult your doctor immediately.

5. Is Dapaglyn S 10/100 MG Tablet safe during pregnancy or breastfeeding?

There is limited information regarding the use of Dapaglyn S 10/100 MG Tablet during pregnancy. One of its active ingredients, dapagliflozin, is contraindicated during the second and third trimesters of pregnancy. Therefore, this medicine should generally not be used during pregnancy, and you should inform your doctor if you are pregnant or planning to become pregnant.

For breastfeeding women, there is no information available on whether Dapaglyn S 10/100 MG Tablet passes into human breast milk. Therefore, it is generally not recommended for use while breastfeeding, and medical advice should be sought.

6. Can Dapaglyn S 10/100 MG Tablet be taken with other medications?

Dapaglyn S 10/100 MG Tablet can interact with other medications. It is crucial to inform your doctor about all other medicines, herbal products, and supplements you are currently taking or plan to take to avoid potential interactions.

Particular care should be taken if you are taking:

• Diuretics (water pills like furosemide or hydrochlorothiazide), as this can increase the risk of dehydration and low blood pressure.
• Insulin or insulin secretagogues (e.g., sulphonylureas), as combining them with Dapaglyn S can increase the risk of extremely low blood sugar levels (hypoglycemia), potentially requiring a lower dose of these medications.
• Medicines for fungal infections (e.g., ketoconazole) or bacterial infections (e.g., clarithromycin).
• Medicines for heart failure (e.g., digoxin).
• Oral contraceptives or certain antibiotics may also affect blood sugar levels.

Your doctor will determine if it is suitable to take Dapaglyn S with your other medications.

7. What precautions should be taken while taking Dapaglyn S 10/100 MG Tablet?

• Kidney and Liver Issues: Inform your doctor if you have any kidney or liver problems, as dosage adjustments may be needed or the medicine might be contraindicated in severe cases.
• Dehydration: This medicine can cause your body to lose too much fluid (dehydration) and increase urination. Drink plenty of water and stay hydrated.
• Infections: Be aware of symptoms of urinary tract infections or genital fungal infections and maintain good hygiene to help prevent them.
• Alcohol Consumption: Avoid excessive alcohol intake, as it can interfere with the medicine's effectiveness and affect blood sugar levels, increasing the risk of side effects.
• Type 1 Diabetes: This medicine is not for people with type 1 diabetes or diabetic ketoacidosis.
• Surgery or Stress: Inform your doctor if you are scheduled for surgery or if you experience severe illness, as temporary discontinuation might be necessary.
• Monitoring: Regular monitoring of blood sugar levels is crucial while taking this medication. Do not stop taking the medication abruptly without consulting your doctor, as this can lead to increased blood sugar levels and serious complications.

8. What happens if a dose of Dapaglyn S 10/100 MG Tablet is missed?

If you miss a dose of Dapaglyn S 10/100 MG Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

9. How should Dapaglyn S 10/100 MG Tablet be stored?

Dapaglyn S 10/100 MG Tablet should be stored in a cool and dry place, ideally below 30°C, away from direct sunlight and moisture. Keep it in its original packaging and out of reach of children and pets.