Sacurise 100 Mg Tablet (14 Tab)

SACURISE 100 MG TABLET

Name

Brand Name: SACURISE 100 MG TABLET Common Name: Sacubitril/Valsartan (combination)

Composition

SACURISE 100 MG TABLET is a fixed-dose combination medication containing two active ingredients:

• Sacubitril: 49 mg
• Valsartan: 51 mg

These belong to the class of angiotensin receptor neprilysin inhibitors (ARNI).

Uses

SACURISE 100 MG TABLET is primarily prescribed for the treatment of chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalization for heart failure by improving heart function and decreasing strain on the heart. The medicine works by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body.

Dosage and Administration

This medicine should be taken exactly as prescribed by a physician. It is typically taken twice daily, with or without food. Tablets should be swallowed whole with a glass of water and not chewed, crushed, or broken. Consistent use at the same time each day is recommended for optimal effectiveness. Do not exceed the recommended dose.

Side Effects

Common Side Effects:

• Low blood pressure (hypotension), often causing dizziness or light-headedness
• Increased potassium levels in the blood (hyperkalemia)
• Cough
• Dizziness
• Diarrhea
• Tiredness/weakness
• Headache
• Nausea

Serious Side Effects (Seek immediate medical attention if experienced):

• Severe allergic reactions, including angioedema (swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing).

Precautions

• Allergies: Do not take if allergic to sacubitril, valsartan, or any other components of the medicine.
• Pregnancy & Breastfeeding: Contraindicated during pregnancy as it may cause serious harm to the baby. It is also not recommended for breastfeeding women.
• Drug Interactions:
  • Avoid use with ACE inhibitors (e.g., captopril, enalapril); a washout period of at least 36 hours before or after taking an ACE inhibitor is necessary.
  • Avoid taking with aliskiren (another blood pressure medication) if you have diabetes or impaired kidney function.
  • Caution with potassium supplements or potassium-sparing diuretics due to the risk of hyperkalemia.
  • Inform your doctor about all other medications, herbal preparations, and supplements being taken.
• Medical Conditions:
  • Use with caution in patients with kidney or liver diseases; dose adjustment and monitoring may be required.
  • Patients should stand up slowly to reduce the risk of orthostatic hypotension (sudden lowering of blood pressure upon standing).
  • Inform your doctor if you have diabetes.
• Alcohol: Avoid consuming alcohol, as it may increase the risk of dizziness and low blood pressure.
• Driving: May cause dizziness or tiredness; avoid driving or operating heavy machinery if affected.
• Pediatric Use: Not suitable for children and adolescents under 18 years of age.
• Geriatric Use: Use with caution in elderly patients (65 years of age and above).

Storage

Store in a cool and dry place, away from direct sunlight. Keep out of the sight and reach of children. Store at room temperature, ideally below 30°C or between 10ºC to 25ºC. Store in the original package to protect from moisture and light.

SACURISE 100 MG TABLET (14 TAB) by SUN PHARMACEUTICAL IND.LTD. - FAQs

What is Sacurise 100 Tablet used for?

Sacurise 100 Tablet is primarily used to treat chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalization by improving heart function and decreasing the strain on the heart. It may also be used for hypertension management.

How does Sacurise 100 Tablet work?

Sacurise 100 Tablet is a combination of two medicines: sacubitril and valsartan. Sacubitril is a neprilysin inhibitor that works by relaxing and widening blood vessels, promoting the excretion of sodium and increasing urination. Valsartan is an angiotensin II receptor blocker (ARB) that blocks the effects of angiotensin II, a hormone that constricts blood vessels. Together, they make it easier for the heart to pump blood throughout the body, reduce blood pressure, and help the body retain less water.

What is the usual dosage of Sacurise 100 Tablet?

The dosage of Sacurise 100 Tablet is determined by your doctor based on your medical condition and how you respond to the medicine. It is typically taken orally, usually twice daily, with or without food, and swallowed whole with a glass of water. It's important to take it at the same time each day for optimal results and not to alter the prescribed dosage without consulting your doctor.

What are the possible side effects of Sacurise 100 Tablet?

Common side effects may include low blood pressure (hypotension), increased potassium levels in the blood (hyperkalemia), cough, dizziness, nausea, diarrhea, and weakness. Some serious but rare side effects include severe allergic reactions like angioedema (swelling of the face, lips, tongue, or throat). If side effects are severe or persistent, you should consult your doctor.

Is Sacurise 100 Tablet safe during pregnancy or breastfeeding?

No, Sacurise 100 Tablet is not recommended during early pregnancy and must not be used after the first three months of pregnancy, as it can cause serious harm to the unborn baby. It is also not recommended for use in breastfeeding women. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can Sacurise 100 Tablet be taken with other medications?

It is crucial to inform your doctor about all medications you are currently taking, including prescription, over-the-counter medicines, herbal preparations, and supplements, to avoid possible drug interactions. Sacurise 100 Tablet should not be taken with ACE inhibitors (e.g., captopril or enalapril), and there should be a gap of at least 36 hours before or after taking an ACE inhibitor. Concomitant use with aliskiren (especially in patients with diabetes or kidney disease), sildenafil, certain potassium-sparing diuretics (e.g., amiloride, spironolactone), potassium supplements, or NSAIDs (painkillers) can lead to adverse effects like low blood pressure, high blood potassium levels, or worsening kidney function.

What precautions should be taken while on Sacurise 100 Tablet?

Inform your doctor if you have kidney or liver diseases, diabetes, a history of angioedema, or low blood pressure. Patients should get up slowly and carefully to reduce the risk of dizziness caused by sudden lowering of blood pressure (orthostatic hypotension). Regular monitoring of blood pressure and kidney function is advised. Avoid alcohol, as it may increase dizziness and low blood pressure. Avoid consuming potassium-rich foods or supplements, or salt substitutes containing potassium, as this medicine can increase blood potassium levels.

What happens if a dose of Sacurise 100 Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Sacurise 100 Tablet be stored?

Sacurise 100 Tablet should be stored in a cool and dry place, away from direct sunlight, and out of the sight and reach of children. It should be kept in its original package to protect it from moisture. Do not store above 25°C or 30°C, depending on specific instructions.