Ivanode Od 10 Tab

IVANODE OD 10 Tablet

Name

Common Name: Ivabradine (as 10mg tablets) Brand Name: Ivanode OD 10 Tablet (manufactured by Torrent Pharmaceuticals Ltd.)

Composition

Active Ingredient: Each tablet contains Ivabradine 10 mg. Ivanode OD 10 Tablet is classified as a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.

Uses

Ivanode OD 10 Tablet is primarily used for the treatment of:

• Stable Angina Pectoris: Heart-related chest pain. It helps reduce the frequency and severity of angina attacks by lowering the heart rate and reducing the heart's oxygen demand.
• Chronic Heart Failure: It manages symptoms, improves heart function, and reduces the risk of hospitalization in adults with chronic heart failure, especially when the resting heart rate is elevated (typically above 70-75 beats per minute) and beta-blockers cannot be used or require additional support.

Dosage and Administration

This medication should be taken orally with food, typically at the same time each day, as prescribed by a healthcare professional. Do not break, crush, or chew the tablet. The treatment for angina or heart failure is often lifelong, and patients should not discontinue use without consulting their doctor. Do not exceed the prescribed dose.

Side Effects

Common Side Effects:

• Luminous phenomena (temporary brightness or visual disturbances)
• Slow heart rate (bradycardia)
• High blood pressure (hypertension)
• Atrial fibrillation (irregular heartbeat)
• Dizziness
• Blurred vision
• Headache
• Tiredness
• Nausea, abdominal pain, diarrhea
• ECG changes

Serious Side Effects: Fainting and significant changes in heartbeat patterns require immediate medical attention.

Precautions

• Contraindications: Do not use if allergic to Ivabradine or any components, if experiencing very low blood pressure, a resting heart rate below 70 beats per minute, certain heart conditions (sick sinus syndrome, sino-atrial block, 3rd-degree AV block, cardiogenic shock, heavy heart attack), or severe liver problems.
• Pregnancy and Breastfeeding: Not recommended during pregnancy or for women planning pregnancy, as it may harm the unborn baby. Effective birth control measures should be used. Not recommended for breastfeeding mothers.
• Children: Not recommended for individuals under 18 years of age.
• Driving and Operating Machinery: May cause dizziness or visual disturbances; exercise caution.
• Interactions: Inform your doctor about all medications, including herbal supplements and vitamins. Avoid strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) and grapefruit juice. Use with caution with certain antiarrhythmics, antidepressants, and other heart medications.
• Alcohol: Avoid consuming alcohol during treatment.

Storage

Store Ivanode OD 10 Tablet at room temperature, protected from moisture and heat, ideally below 30°C. Keep away from direct light and ensure it is out of reach and sight of children and pets.

IVANODE OD 10 TAB contains the active ingredient Ivabradine, a medication primarily used for certain heart conditions. It works by specifically slowing the heart rate.

Here are some frequently asked questions about IVANODE OD 10 TAB:

What is IVANODE OD 10 TAB used for?

IVANODE OD 10 TAB is primarily used to treat chronic heart failure and symptomatic stable angina pectoris (chest pain related to the heart) in adults. It helps to reduce the risk of hospitalization for worsening heart failure and can also be used in pediatric patients (6 months and older) with symptomatic heart failure due to dilated cardiomyopathy.

How does IVANODE OD 10 TAB work?

This medicine works by selectively inhibiting the "funny" channel pacemaker current (If) in the heart's sinoatrial (SA) node. This action reduces the heart rate and allows more time for blood to flow to the heart muscle. By slowing the heart rate, it reduces the heart's workload and improves its efficiency without directly affecting the heart's pumping strength (contractility).

What is the usual dosage for IVANODE OD 10 TAB?

For adults, the typical starting dose is 5 mg twice daily, taken with food. Your doctor may adjust the dose after two weeks to achieve a resting heart rate between 50 and 60 beats per minute (bpm). The maximum recommended dose is usually 7.5 mg twice daily. For children, the dosage depends on their weight and age, starting from 0.05 mg/kg or 2.5 mg twice daily, adjusted as needed by a doctor.

What are the possible side effects of IVANODE OD 10 TAB?

Common side effects can include a slow heartbeat (bradycardia), temporary bright spots in vision (phosphenes or luminous phenomena), increased blood pressure, atrial fibrillation (an irregular heart rhythm), dizziness, headache, blurred vision, and tiredness. More serious side effects, though less common, can include severe bradycardia, worsening shortness of breath, chest pain, and fainting. If you experience serious side effects, contact your doctor immediately.

Is IVANODE OD 10 TAB safe during pregnancy or breastfeeding?

No, IVANODE OD 10 TAB is not safe during pregnancy and is generally contraindicated. It may cause harm to an unborn baby, so women who could become pregnant should use effective contraception while taking this medication. If you become pregnant, stop taking it immediately and contact your doctor. Breastfeeding is also not recommended, and it should be discontinued if you are taking IVANODE OD 10 TAB.

Can IVANODE OD 10 TAB be taken with other medications?

IVANODE OD 10 TAB should not be taken with certain medications, including strong CYP3A4 inhibitors like some antifungals (e.g., ketoconazole, itraconazole), certain antibiotics (e.g., clarithromycin), HIV/AIDS medications, some antidepressants (e.g., nefazodone), and certain calcium channel blockers (e.g., diltiazem, verapamil). Concomitant use with other heart rate-lowering drugs like digoxin, amiodarone, or beta-blockers should be done with caution, as it may increase the risk of an excessively slow heart rate. You should also avoid grapefruit juice and St. John's wort while on this medication.

What precautions should be taken while using IVANODE OD 10 TAB?

Before starting IVANODE OD 10 TAB, inform your doctor if you have a very slow resting heart rate (below 70 bpm), very low blood pressure, severe liver problems, certain heart rhythm disorders (unless you have a pacemaker controlling your heart rate), unstable angina, or recently worsening heart failure. Regular monitoring of your heart rate is important. If you experience visual disturbances, such as temporary brightness, be cautious when driving or operating machinery, especially at night or in changing light conditions.

What happens if a dose of IVANODE OD 10 TAB is missed?

If you miss a dose, simply skip it and take your next dose at the regularly scheduled time. Do not take a double dose to compensate for a missed one.

How should IVANODE OD 10 TAB be stored?

IVANODE OD 10 TAB should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F), and protected from moisture and heat. Keep it in its original packaging and out of the reach of children and pets. Do not use the medicine after its expiry date.