Oxra S 10/50 Mg (15 Tab)

OXRA S 10/50 MG (15 TAB) by SUN PHARMA LABORATORIES LTD.

This detailed product description provides information on OXRA S 10/50 MG, a medication manufactured by Sun Pharma Laboratories Ltd., commonly prescribed for managing type 2 diabetes mellitus.

Name

• Brand Name: OXRA S 10/50

Composition

• Active Ingredients: Each tablet contains Dapagliflozin 10 mg and Sitagliptin Phosphate 50 mg.
  • Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that helps the kidneys remove excess sugar through urine.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases insulin levels after a meal and decreases glucose production by the liver.

Uses OXRA S 10/50 is prescribed for:

• Management of type 2 diabetes mellitus in adults to control blood sugar levels and improve glycemic control, often used in conjunction with diet and exercise.
• Reducing the risk of cardiovascular events, including heart attack and heart failure, and slowing the progression of kidney disease in patients with type 2 diabetes.

Dosage and Administration

• Take OXRA S 10/50 orally as directed by a healthcare provider.
• It is typically taken once daily, with or without food, preferably at the same time each day for optimal benefits.
• Do not crush, cut, or chew the tablet.
• Do not stop taking the medicine abruptly without consulting a doctor, as this may lead to increased blood sugar levels and potential complications.

Side Effects Common side effects may include:

• Hypoglycemia (low blood sugar levels)
• Urinary tract infections (UTIs)
• Genital yeast infections
• Increased urination
• Thirst
• Nasal congestion, sore throat, and upper respiratory tract infections
• Headache
• Diarrhea, nausea, and vomiting
• Flatulence and constipation

Serious side effects, though rare, can include pancreatitis (severe and persistent stomach pain) and serious allergic reactions (rash, hives, swelling of the face, tongue, or throat).

Precautions

• Pregnancy and Breastfeeding: Not recommended during pregnancy and breastfeeding. Consult a doctor for alternative treatments.
• Alcohol: Avoid excessive alcohol consumption, as it may increase the risk of hypoglycemia.
• Kidney and Liver Conditions: Use with caution in patients with kidney disorders or liver disease. Regular monitoring may be essential. Not recommended for patients with severe kidney problems or those on dialysis.
• Other Conditions: Exercise caution if you have a history of pancreatitis, gallstones, heart problems, dehydration, or very high triglyceride levels.
• Drug Interactions: Inform your doctor about all medications you are taking, including insulin, other antidiabetic drugs, diuretics (e.g., furosemide, hydrochlorothiazide), and certain antifungals (e.g., ketoconazole), antibacterials (e.g., clarithromycin), or HIV/AIDS medications (e.g., ritonavir), and heart failure medications (e.g., digoxin).
• Food Interactions: Grapefruit and grapefruit juice may interact with OXRA S 10/50.
• Elderly Patients: Can be used in the elderly, but dosage adjustments may be necessary.
• Children: Not indicated for use in children; safety and efficacy have not been established.

Storage

• Store OXRA S 10/50 in a cool, dry place, away from direct sunlight.
• Keep it out of reach of children.
• Store below 30°C, ideally between 20°C and 25°C.
• Do not use this medication past its expiration date.

What is OXRA S 10/50 MG used for?

OXRA S 10/50 MG is a combination medicine used in adults with type 2 diabetes mellitus to help control blood sugar levels. It is typically prescribed when blood sugar is not adequately controlled by metformin alone, or in conjunction with diet and exercise. It may also help reduce the risk of hospitalization for heart failure and the risk of worsening kidney disease in certain patients.

How does OXRA S 10/50 MG work?

This medicine contains two active ingredients: Dapagliflozin and Sitagliptin. Dapagliflozin works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2), which is responsible for reabsorbing sugar back into the blood. This causes the kidneys to remove more sugar from the body through urine, thereby lowering blood sugar levels. Sitagliptin works by increasing the levels of certain natural substances in the body (incretin hormones) that help the pancreas release more insulin after a meal and decrease the amount of sugar the liver produces.

What is the usual dosage for OXRA S 10/50 MG?

The typical dosage for adults with type 2 diabetes is one tablet (10 mg dapagliflozin and 50 mg sitagliptin) taken orally once daily in the morning, with or without food. It is important to swallow the tablet whole and not to split or cut it. Your doctor will determine the appropriate dosage for your specific condition.

What are the possible side effects of OXRA S 10/50 MG?

Common side effects include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, headache, diarrhea, and genital fungal infections. Increased urination and thirst are also common. More serious but less common side effects can include severe joint pain, pancreatitis (severe stomach pain), diabetic ketoacidosis (high ketones in blood), severe allergic reactions (like angioedema or skin blisters), and a rare but serious bacterial infection called Fournier's gangrene in the genital area.

Is OXRA S 10/50 MG safe during pregnancy or breastfeeding?

OXRA S 10/50 MG is generally not recommended for use during pregnancy or breastfeeding. There is limited information on its effects in pregnant women, and it is unknown if the medicine passes into human breast milk. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this medication.

Can OXRA S 10/50 MG be taken with other medications?

OXRA S 10/50 MG can interact with certain medications. It is important to inform your doctor about all other medicines, herbal products, and supplements you are currently taking. Using it with diuretics (water pills) may increase the risk of dehydration and low blood pressure. If taken with insulin or insulin secretagogues (like sulfonylureas), the risk of dangerously low blood sugar (hypoglycemia) can increase, and dosage adjustments may be necessary. Caution is also advised with certain antibiotics like rifampin or anti-coagulants like digoxin.

What precautions should be taken while taking OXRA S 10/50 MG?

This medicine is not for individuals with type 1 diabetes or diabetic ketoacidosis. Your doctor will monitor your kidney function before and during treatment, as it is not recommended for severe kidney impairment or patients on dialysis. Stay well-hydrated to prevent dehydration. Report any symptoms of pancreatitis (severe abdominal pain), urinary tract infections (burning urination), or genital infections (itching, discharge) to your doctor immediately. Avoid excessive alcohol consumption. If you are scheduled for surgery or any procedure requiring fasting, you may need to stop this medicine temporarily.

What happens if a dose of OXRA S 10/50 MG is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose (typically less than 12 hours until the next dose), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should OXRA S 10/50 MG be stored?

Store OXRA S 10/50 MG in a cool, dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children. Do not use the medication past its expiration date.