Arnisac 100

ARNISAC 100

ARNISAC 100 is a medication manufactured by MANKIND PHARMA LTD.

• Composition: Each tablet contains Sacubitril 49 mg and Valsartan 51 mg. This combination belongs to a class of medicines called Angiotensin Receptor Neprilysin Inhibitors (ARNIs).

• Uses: ARNISAC 100 is primarily indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction. It works by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body.

• Dosage and Administration: Take ARNISAC 100 as advised by your physician. It should be swallowed whole with a glass of water, with or without food, preferably at a fixed time each day. Do not crush or chew the tablet. The correct dose and duration depend on your age, body weight, and disease condition.

• Side Effects:

  • Common: Dizziness, light-headedness (due to low blood pressure), cough, headache, tiredness, nausea, diarrhea, weakness, signs of high levels of potassium in the blood (e.g., irregular heartbeat, muscle weakness), and decreased renal function.
  • Serious: Swelling of the face, lips, or throat (angioedema), severe dizziness or fainting, elevated potassium levels, and kidney problems.

• Precautions:

  • ARNISAC 100 is contraindicated in pregnant women (especially after 3 months) and is not recommended for use in breastfeeding women due to potential harm to the baby.
  • It should not be taken if you have a severe liver disease or an allergy to sacubitril, valsartan, or any other ingredients.
  • A 36-hour washout period is required if transitioning from an ACE inhibitor to ARNISAC 100 to avoid the risk of angioedema.
  • Caution is advised in elderly patients and those with kidney or liver problems; dose adjustments may be necessary.
  • Avoid driving or operating machinery if you experience dizziness or tiredness. Limit alcohol consumption as it may intensify side effects.

• Storage: Store ARNISAC 100 in a closed container at room temperature, ideally below 30°C, away from direct sunlight and moisture. Keep it out of the sight and reach of children. Always check the expiry date.

What is ARNISAC 100 used for?

ARNISAC 100 Tablet is primarily used to treat chronic heart failure in adults, particularly in patients with reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalizations related to heart failure. This condition occurs when the heart is weak and cannot pump enough blood to the lungs and the rest of the body, leading to symptoms like breathlessness, fatigue, and swelling in the ankles. It can also be used to manage hypertension (high blood pressure) and prevent heart failure-related hospitalizations and cardiovascular events like stroke and heart attack.

How does ARNISAC 100 work?

ARNISAC 100 Tablet is a combination medicine containing Sacubitril (49mg) and Valsartan (51mg), belonging to a class of drugs called angiotensin receptor neprilysin inhibitors (ARNIs).

• Sacubitril works by inhibiting an enzyme called neprilysin. By doing so, it increases the levels of natriuretic peptides, which help relax blood vessels, increase the excretion of sodium and water through urine, and reduce the strain on the heart.
• Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. By blocking this, valsartan helps relax blood vessels, lower blood pressure, and reduce the workload on the heart, making it easier for the heart to pump blood throughout the body.

Together, these actions improve heart function, lower blood pressure, and help the body retain less water.

What is the usual dosage of ARNISAC 100?

The dose and frequency of ARNISAC 100 Tablet are determined by your doctor based on your medical condition and response to the medication. It's important to take the tablet whole with a glass of water, with or without food, at the same time each day for maximum benefits. Do not crush, chew, or break the tablet. It is crucial not to exceed the prescribed dose and to continue taking the medication regularly as advised by your doctor, even if you feel better.

What are the possible side effects of ARNISAC 100?

Common side effects of ARNISAC 100 Tablet include dizziness, light-headedness, low blood pressure (hypotension), increased potassium levels in the blood (hyperkalemia), cough, tiredness or weakness, stomach pain, and loose stools (diarrhea). These side effects are usually mild and may resolve over time. If they persist or worsen, you should consult your doctor. To minimize dizziness, it's advised to get up slowly from a sitting or lying position.

Is ARNISAC 100 safe during pregnancy or breastfeeding?

No, ARNISAC 100 Tablet is generally not recommended during pregnancy, especially after the first three months, as it can harm the unborn baby or even endanger its life. Women of childbearing age should use effective contraception while taking this medicine. If you become pregnant while taking ARNISAC 100, stop using it immediately and contact your doctor. It is also not recommended for lactating mothers or during breastfeeding due to potential risks to the baby, as the drug may pass into breastmilk.

Can ARNISAC 100 be taken with other medications?

ARNISAC 100 Tablet can interact with several other medications. It should not be taken with Angiotensin-Converting Enzyme (ACE) inhibitors (e.g., enalapril, lisinopril, ramipril); a waiting period of at least 36 hours is required between taking an ACE inhibitor and ARNISAC 100. Concomitant use with:

• Aliskiren (a blood pressure-lowering medicine), especially in patients with diabetes or kidney disease, is contraindicated.
• Other angiotensin receptor blockers (ARBs) like telmisartan or losartan.
• Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene), potassium supplements, or potassium-containing salt substitutes, as this can increase blood potassium levels.
• Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, particularly in elderly patients or those with dehydration or kidney disease, as this can worsen kidney function.
• Sildenafil can cause a further decrease in blood pressure.
• Heparin or warfarin can interact.

Always inform your doctor about all medicines, herbal preparations, and supplements you are currently taking to avoid potential drug interactions.

What precautions should be taken?

Inform your doctor about any pre-existing medical conditions, especially liver disease (it is contraindicated in severe liver disease), kidney disease (caution is advised, and dose adjustment may be needed), or a history of angioedema (swelling of the face, lips, tongue, or throat). ARNISAC 100 can cause dizziness or tiredness, so be cautious when driving or operating machinery. Alcohol consumption should be limited or avoided as it can intensify side effects like dizziness. Your doctor may advise regular monitoring of blood pressure and kidney function while you are on this medication.

What happens if a dose is missed?

If you miss a dose of ARNISAC 100 Tablet, take it as soon as you remember. However, if it's nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Never increase your dosage without consulting your doctor.

How should it be stored?

ARNISAC 100 Tablet should be stored at room temperature, away from light and moisture, in its original packaging. Keep it out of reach of children and pets.