Hynidase Inj

HYNIDASE INJ

HYNIDASE INJ is a medical product manufactured by SHREYA LIFE SCIENCES PVT. LTD..

• Name

  • Brand Name: Hynidase Inj
  • Common Name: Hyaluronidase Injection

• Composition

  • Active Ingredient: Hyaluronidase (1500 IU)

• Uses HYNIDASE INJ is an enzyme primarily used to enhance the absorption and dispersion of other injected medications and fluids. It works by temporarily breaking down hyaluronic acid, a natural barrier in body tissues, to increase tissue permeability. Specific uses include:

  • Facilitating the spread and absorption of fluids and injections given subcutaneously or intramuscularly.
  • Treating dehydration when combined with injected fluids.
  • Improving the reabsorption of excess fluids and blood in tissues.
  • Enhancing the visibility of contrast dyes in certain X-rays or scans.
  • Managing extravasation of fluids or blood.

• Dosage and Administration HYNIDASE INJ is administered by a doctor or nurse either into a muscle (intramuscular) or under the skin (subcutaneous). The correct dose and duration are determined by the doctor based on the patient's age, body weight, and medical condition. It should not be self-administered or injected into a vein (intravenous) as the enzyme is rapidly inactivated.

• Side Effects Common side effects may include:

  • Injection site reactions (redness, swelling, pain, irritation, bruising).
  • Oedema (fluid buildup causing swelling). Rare but serious side effects can include:
  • Allergic reactions (rash, itching, swelling around the eyes, face, lips, tongue, difficulty breathing).
  • Angioedema (swelling of deeper layers of skin).
  • Anaphylaxis-like reactions (if used near the eye or mistakenly in the vein).

• Precautions

  • Allergies: Do not receive HYNIDASE INJ if allergic to Hyaluronidase or any of its ingredients. A skin test may be done to check for allergies.
  • Contraindications: Not recommended for use in swelling of bites or stings, at sites of infection or malignancy, directly onto the front of the eye, or in premature labor. It should not be injected into or around an infected or inflamed area due to the risk of spreading the infection.
  • Specific Populations: Use with caution in pregnant and breastfeeding women, children, and elderly patients.
  • Drug Interactions: Inform your doctor if you are taking dopamine, local anesthetics (e.g., lidocaine), salicylates (e.g., aspirin), cortisone, cinnarizine, estrogens, furosemide, benzodiazepines (e.g., diazepam), or phenytoin, as HYNIDASE INJ may affect their absorption and effectiveness or increase side effects.

• Storage HYNIDASE INJ should be stored at temperatures not exceeding 25°C or below 30°C. Keep ampoules in their packaging to protect them from light and contamination. Any unused or expired medication, or discolored powder or solution, must be discarded responsibly.

What is Hynidase Injection used for?

Hynidase Injection is primarily used as an enzyme to enhance the absorption and dispersion of other injected fluids or medications into the body. This includes aiding in hydration by facilitating subcutaneous fluid administration, improving the spread and effectiveness of injected drugs, and enhancing the absorption of contrast agents used in certain imaging tests like subcutaneous urography. It is also used to help reabsorb excess fluids and blood in tissues and can be used to treat extravasation (when medication leaks from a vein into surrounding tissues).

How does Hynidase Injection work?

Hynidase Injection contains Hyaluronidase, an enzyme that works by temporarily breaking down hyaluronic acid. Hyaluronic acid is a natural substance in the body that acts like a gel or barrier in the connective tissue, binding cells together and retaining water. By hydrolyzing (breaking down) hyaluronic acid, Hynidase increases the permeability of the tissue, allowing fluids, medications, or contrast agents to spread and be absorbed more easily and quickly.

What is the usual dosage for Hynidase Injection?

Hynidase Injection is administered by a healthcare professional, such as a doctor or nurse, either into a muscle (intramuscular) or under the skin (subcutaneous). The specific dosage and duration depend on the condition being treated, the patient's age, body weight, and medical history. For enhancing absorption of injected solutions, a common dose can be 50-300 units (typically 150 units) added to the solution. For hypodermoclysis (subcutaneous fluid administration for hydration), 1500 units dissolved in 1 mL of water for injection or saline may be injected.

What are the possible side effects of Hynidase Injection?

Common side effects of Hynidase Injection can include injection site reactions such as pain, redness, swelling, or irritation. Other reported side effects include headache, nausea, vomiting, dizziness, edema (swelling due to fluid buildup), hormone imbalance, and angioedema (swelling of deeper layers of skin). Serious, though rare, side effects can include severe allergic reactions (rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, wheezing, chest tightness) and anaphylaxis-like reactions. There is also a risk of spreading infection if injected into an infected or acutely inflamed area.

Is Hynidase Injection safe during pregnancy or breastfeeding?

Hynidase Injection may be unsafe to use during pregnancy. Animal studies have shown harmful effects on the developing baby, and there are limited human studies. It is classified as pregnancy category C. Similarly, information regarding its safety during breastfeeding is limited, and its use is generally not established. Therefore, Hynidase Injection should only be used in pregnant or breastfeeding women if the potential benefits outweigh the potential risks, and only under the strict guidance of a doctor.

Can Hynidase Injection be taken with other medications?

Hynidase Injection can interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. It is incompatible with or may have reduced efficacy when taken with furosemide, phenytoin, sedatives (benzodiazepines), salicylates (including aspirin), heparin, epinephrine, dopamine, alpha agonists, cortisone, ACTH, estrogens, and certain antihistamines. If used with local anesthetics, Hynidase may accelerate the onset of anesthesia but could also shorten its duration of action and increase the chance of anesthetic side effects. Always inform your doctor about all medications you are currently taking, including over-the-counter drugs, vitamins, and herbal products.

What precautions should be taken with Hynidase Injection?

Before receiving Hynidase Injection, inform your doctor if you have any known allergies to hyaluronidase or any of its components; a skin test may be performed to check for allergies. It should not be injected into or around an infected or acutely inflamed area due to the risk of spreading the infection. Hynidase should not be used to reduce swelling from bites or stings. It should not be injected directly into a vein (intravenously) as the enzyme is rapidly inactivated. Use with caution in children and elderly patients, particularly those with kidney problems, to avoid over-hydration. Patients with cardiovascular disease, thyroid disease, diabetes, bleeding disorders, or those taking anticoagulant medications should also inform their doctor.

What happens if a dose of Hynidase Injection is missed?

Since Hynidase Injection is administered by a healthcare professional, a missed dose is unlikely. However, if a dose is forgotten or if you have concerns, you should consult your doctor immediately for guidance. Do not attempt to self-administer or double the dose to make up for a missed one.

How should Hynidase Injection be stored?

Hynidase Injection should be stored in a cool, dry place, typically below 30°C or 25°C. Some formulations (solution for injection) may require storage between 2-8°C and should not be frozen. It should be kept out of the sight and reach of children. Once prepared (if it comes as a powder for reconstitution), the injection should be administered immediately, and any remaining solution must be discarded.