Linaxa E 25mg Tab

LINAXA E 25MG TAB

Name

Brand Name: LINAXA E 25MG TAB Common Names: Empagliflozin and Linagliptin (Fixed-dose combination)

Composition

LINAXA E 25MG TAB contains a combination of two active ingredients: Empagliflozin 25 mg and Linagliptin 5 mg.

Uses

LINAXA E 25MG TAB is prescribed for adults with Type 2 Diabetes Mellitus. It is used as an adjunct to diet and exercise to improve blood sugar control. This medication also helps in the management of cardiovascular disease and may reduce the risk of heart attack or stroke. Additionally, it is used to reduce kidney disease and protect kidneys from losing function in adults with reduced kidney function. By managing blood sugar levels, it aids in preventing diabetic complications such as eyesight problems (retinopathy), kidney problems (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

Dosage and Administration

LINAXA E 25MG TAB is typically taken orally once daily, usually in the morning, with or without food. The tablet should be swallowed whole with water and not crushed, chewed, or broken. It is important to take the medicine at the same time each day for consistent results. The specific dosage is determined by a doctor based on the patient's condition and response to treatment. Do not stop taking this medication abruptly without consulting your doctor, as this can lead to an increase in blood sugar levels and potential complications.

Side Effects

Common Side Effects:

• Urinary tract infections (UTIs)
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Frequent urination
• Dizziness or lightheadedness
• Cough
• Rash or itching
• Low blood sugar levels (hypoglycemia), especially when used with insulin or sulfonylureas
• Stomach discomfort, nausea, or constipation
• Genital fungal infections

Serious Side Effects:

• Ketoacidosis
• Pancreatitis
• Volume depletion, which may manifest as symptomatic hypotension
• Urosepsis and Pyelonephritis (serious urinary tract infections)
• Necrotizing Fasciitis of the Perineum (Fournier's gangrene)
• Severe and disabling arthralgia
• Bullous Pemphigoid
• Heart failure (observed with other DPP-4 inhibitors)

Precautions

• LINAXA E 25MG TAB is not recommended for individuals with Type 1 diabetes mellitus or severe kidney or liver disease.
• Assess renal function before initiating this tablet.
• Inform your doctor if you have kidney or liver problems, a urinary tract infection, or are taking diuretics (water pills).
• Pregnant or breastfeeding women should consult their doctor before taking this medicine, as it is generally not advised during pregnancy (especially the second and third trimesters) or while breastfeeding.
• Avoid or limit alcohol consumption while on this medication, as it can cause fluctuations in blood sugar levels and may increase the risk of certain side effects like low blood sugar or dehydration.
• Close monitoring of blood sugar levels is essential during treatment.
• Concomitant use with insulin or insulin secretagogues (e.g., sulfonylureas) may increase the risk of hypoglycemia.
• LINAXA E 25MG TAB is not recommended for use in children and adolescents below 18 years of age.

Storage

Store LINAXA E 25MG TAB at room temperature, typically between 20°C to 25°C or below 30°C. Keep it in a cool, dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children.

What is LINAXA E 25MG Tablet used for?

LINAXA E 25MG Tablet is a combination medication used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is typically prescribed alongside a proper diet and exercise program. This medicine also helps prevent serious complications associated with diabetes, such as kidney damage, eyesight loss (retinopathy), nerve damage (neuropathy), diabetic foot ulcers, and delayed wound healing. It can also be used to treat chronic kidney disease in adults with reduced kidney function and may offer cardiovascular benefits.

How does LINAXA E 25MG Tablet work?

LINAXA E 25MG Tablet contains two active ingredients: Empagliflozin (25mg) and Linagliptin (5mg).

• Empagliflozin works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2). This prevents the kidneys from reabsorbing glucose (sugar) back into the bloodstream, causing more sugar to be removed from the body through urine, thereby lowering blood sugar levels.
• Linagliptin acts by blocking an enzyme called dipeptidyl-peptidase 4 (DPP-4). This leads to increased levels of natural substances called incretins, which help the pancreas produce more insulin when blood sugar levels are high (like after a meal) and also reduce the amount of sugar the liver makes. Together, these mechanisms help to effectively manage blood sugar levels.

What is the usual dosage for LINAXA E 25MG Tablet?

LINAXA E 25MG Tablet should be taken orally once daily, with or without food, exactly as directed by your doctor. It is recommended to take it at the same time each day for best results. Do not exceed the prescribed dose.

What are the possible side effects of LINAXA E 25MG Tablet?

Common side effects of LINAXA E 25MG Tablet can include urinary tract infections, nasopharyngitis (inflammation of the throat and nasal passages), upper respiratory tract infections, frequent urination, cough, rash, itching, low blood sugar levels (hypoglycemia), dizziness, lightheadedness, nausea, gas, and stomach pain. Less common but serious side effects can include severe or ongoing diarrhea, severe stomach pain, and in rare cases, conditions like metabolic acidosis or necrotizing fasciitis of the perineum (Fournier's gangrene). If you experience severe or persistent side effects, or symptoms like bloody/tarry stools, severe dizziness, leg cramps, or confusion, seek immediate medical attention.

Is LINAXA E 25MG Tablet safe during pregnancy or breastfeeding?

LINAXA E 25MG Tablet is generally not advised during pregnancy or while breastfeeding due to limited information on its effects and potential risks to the baby. If you are pregnant, planning a pregnancy, or breastfeeding, you should discuss alternative diabetes treatments with your doctor.

Can LINAXA E 25MG Tablet be taken with other medications?

LINAXA E 25MG Tablet can be used with other diabetes medications if prescribed by your doctor. However, close monitoring of blood sugar levels is crucial, as combining multiple medications, especially insulin or sulfonylureas, can increase the risk of low blood sugar (hypoglycemia). It's important to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid possible interactions. There are no known significant drug-food interactions.

What precautions should be taken with LINAXA E 25MG Tablet?

Before taking this medication, inform your doctor if you have kidney or liver problems, a urinary tract infection, or are taking diuretics (water pills). Avoid excessive alcohol intake, as it can lead to fluctuations in blood sugar levels or increase the risk of low blood sugar and dehydration. Stay well-hydrated, especially during physical activity or in hot weather. Regular monitoring of blood sugar levels is important throughout treatment. Do not stop taking the medication abruptly without consulting your doctor, as this can cause blood sugar levels to spike and lead to serious complications.

What happens if a dose of LINAXA E 25MG Tablet is missed?

If you miss a dose of LINAXA E 25MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Missing blood sugar medication can lead to high blood sugar.

How should LINAXA E 25MG Tablet be stored?

LINAXA E 25MG Tablet should be stored at room temperature, typically between 20°C to 25°C, or below 30°C. Keep it away from light and moisture, and out of the sight and reach of children.