Gluxit Trio 10/100/1000 Mg Tablet (15 Tab)

GLUXIT TRIO 10/100/1000 MG TABLET

GLUXIT TRIO 10/100/1000 MG TABLET, manufactured by Eris Lifesciences Limited, is an antidiabetic medicine prescribed for the management of Type 2 Diabetes Mellitus in adults. This medication is typically used when diet, exercise, and therapy with conventional medicines do not adequately control blood sugar levels.

Composition Each tablet of GLUXIT TRIO 10/100/1000 MG contains three active ingredients:

• Dapagliflozin: 10 mg
• Sitagliptin: 100 mg
• Metformin: 1000 mg

Uses GLUXIT TRIO 10/100/1000 MG TABLET is used to improve blood sugar control in adults with Type 2 Diabetes Mellitus, as an adjunct to diet and exercise. It helps in the proper utilization of insulin and lowers blood sugar levels. The combination of these three drugs offers multi-targeted control, including enhancing insulin secretion, reducing glucose production by the liver, delaying sugar absorption from the intestines, and promoting glucose excretion through the kidneys. It may also help lower the risk of heart failure and diabetic kidney disease.

Dosage and Administration GLUXIT TRIO 10/100/1000 MG TABLET should be taken as advised by your doctor. It is usually taken once daily, preferably with a meal to minimize gastrointestinal side effects associated with metformin. The tablet should be swallowed whole with water and not crushed, broken, or chewed. Consistency is key, and it is recommended to take it at the same time each day. Do not stop taking this medicine without consulting your doctor.

Side Effects Common side effects may include:

• Nausea, vomiting, diarrhea, abdominal pain, stomach upset
• Headache
• Urinary tract infections and female genital mycotic infections
• Increased or more frequent urination
• Hypoglycemia (low blood sugar)
• Nasal congestion, sore throat, and upper respiratory tract infections

Serious side effects, though rare, can include lactic acidosis (especially with metformin accumulation), pancreatitis, and allergic reactions.

Precautions GLUXIT TRIO 10/100/1000 MG TABLET is not recommended for use in patients with severe liver or kidney disease, Type 1 diabetes mellitus, metabolic acidosis, or diabetic ketoacidosis.

• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding, as the use of this medicine is generally not recommended.
• Alcohol: Avoid or limit alcohol consumption while taking this medication as it increases the risk of hypoglycemia and lactic acidosis.
• Drug Interactions: Inform your doctor about all other medications, including herbal supplements, as interactions can occur with sulfonylureas, insulin, diuretics, and certain antifungal or antiviral medicines.
• Dehydration: Drinking plenty of fluids is essential to prevent dehydration.

Storage Store GLUXIT TRIO 10/100/1000 MG TABLET in a cool and dry place, away from direct sunlight, ideally below 30°C. Keep it out of the sight and reach of children.

1. What is GLUXIT TRIO 10/100/1000 MG TABLET used for?

GLUXIT TRIO 10/100/1000 MG TABLET is an anti-diabetic medicine primarily used to manage Type 2 Diabetes Mellitus in adults. It is prescribed when diet, exercise, and therapy with conventional medicines alone do not adequately control blood sugar levels. This medication helps to improve blood sugar control and can aid in preventing diabetes-related complications such as kidney damage, eye problems, and nerve issues. Additionally, it may help lower the risk of heart failure and diabetic kidney disease, and support weight management in some patients.

2. How does GLUXIT TRIO 10/100/1000 MG TABLET work?

This medicine is a combination of three active ingredients: Dapagliflozin (10 mg), Sitagliptin (100 mg), and Metformin (1000 mg).

• Dapagliflozin works by inhibiting a protein in the kidneys called SGLT2, which leads to increased excretion of excess sugar from the body through urine.
• Sitagliptin increases the levels of natural substances called incretins, which help the pancreas release more insulin when blood sugar is high and signal the liver to stop producing sugar.
• Metformin reduces the amount of sugar produced by the liver, delays the absorption of sugar from the intestines, and improves the body's sensitivity to insulin. Together, these three components provide a comprehensive approach to controlling blood sugar levels.

3. What is the usual dosage for GLUXIT TRIO 10/100/1000 MG TABLET?

The dosage of GLUXIT TRIO 10/100/1000 MG TABLET is determined by your doctor based on your individual health condition and response to treatment. It is typically taken once daily, usually with meals, to help minimize potential gastrointestinal side effects associated with Metformin. It is crucial to follow your doctor's instructions precisely and not to alter the prescribed dose or stop the medication without consulting them.

4. What are the possible side effects of GLUXIT TRIO 10/100/1000 MG TABLET?

Common side effects can include nausea, vomiting, diarrhea, abdominal pain, headache, flatulence, urinary tract infections (UTIs), and genital fungal infections. Some individuals may also experience increased or more frequent urination, nasopharyngitis, dizziness, or low blood sugar (hypoglycemia), especially when taken with other antidiabetic medicines or alcohol, or if meals are skipped.

Serious but rare side effects that require immediate medical attention include lactic acidosis (symptoms like weakness, difficulty breathing, or stomach pain), ketoacidosis (nausea, vomiting, confusion, or fruity breath), acute pancreatitis (severe, persistent abdominal pain), or severe allergic reactions (rash, swelling of the face/lips/tongue).

5. Is GLUXIT TRIO 10/100/1000 MG TABLET safe during pregnancy or breastfeeding?

GLUXIT TRIO 10/100/1000 MG TABLET is generally not recommended during pregnancy due to limited information on its effects in pregnant women. If you are pregnant or planning to become pregnant, you should inform your doctor before taking this medicine. Similarly, it is generally not recommended for breastfeeding mothers as it is not known if the active ingredients pass into breast milk. Always consult your doctor if you are breastfeeding.

6. Can GLUXIT TRIO 10/100/1000 MG TABLET be taken with other medications?

It is important to inform your doctor about all other medications, supplements, and herbal remedies you are currently taking, as GLUXIT TRIO 10/100/1000 MG TABLET can interact with certain drugs.

• Taking it with diuretics (water pills) may increase the risk of dehydration, low blood pressure, or lactic acidosis.
• When used with insulin or other insulin secretagogues (like sulfonylureas), it may increase the risk of low blood sugar.
• Interactions can also occur with certain medications for fungal infections, bacterial infections, HIV/AIDS, corticosteroids, and some blood pressure drugs. Your doctor may adjust your dosage or recommend an alternative medication.

7. What precautions should be taken while using GLUXIT TRIO 10/100/1000 MG TABLET?

Several precautions should be observed when taking this medication. It is not recommended for individuals with Type 1 diabetes, diabetic ketoacidosis, severe kidney disease, severe liver disease, respiratory failure, or heart failure. Caution is advised for patients with mild to moderate kidney or liver impairment, and regular monitoring of kidney function is recommended.

Avoid alcohol consumption, as it can increase the risk of hypoglycemia and lactic acidosis. Maintain a healthy diet, engage in regular exercise, and manage your weight as advised by your doctor. Ensure adequate fluid intake to prevent dehydration. Regular monitoring of blood sugar levels is essential. Be cautious if driving or operating machinery, as the medication may cause dizziness or drowsiness.

8. What happens if a dose of GLUXIT TRIO 10/100/1000 MG TABLET is missed?

If you miss a dose of GLUXIT TRIO 10/100/1000 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

9. How should GLUXIT TRIO 10/100/1000 MG TABLET be stored?

GLUXIT TRIO 10/100/1000 MG TABLET should be stored in a cool, dry place, away from direct sunlight. It should be kept out of the sight and reach of children. The ideal storage temperature is typically below 30°C. Ensure the medicine is protected from moisture and humidity to maintain its effectiveness, and do not use it past its expiration date.