Daparyl M 5 / 500 Mg Tablet ( 10 Tab )

Here is a detailed product description for DAPARYL M 5 / 500 MG TABLET (10 TAB):

DAPARYL M 5 / 500 MG TABLET

DAPARYL M 5 / 500 MG TABLET is an anti-diabetic medication manufactured by INTAS PHARMACEUTICALS LTD.

Composition Each tablet contains two active ingredients:

• Dapagliflozin: 5 mg
• Metformin Hydrochloride: 500 mg

Uses DAPARYL M 5 / 500 MG TABLET is primarily used for the management of type 2 diabetes mellitus in adults. It helps to control high blood glucose levels, particularly when diet and exercise alone or other medications are insufficient. This medication works by improving insulin sensitivity, decreasing glucose production in the liver, and promoting the excretion of excess glucose through urine. It also helps reduce the risk of heart failure in patients with type 2 diabetes and established cardiovascular disease.

Dosage and Administration

• DAPARYL M 5 / 500 MG TABLET is typically taken orally, usually once daily in the morning, with or without food. Taking it with food may help reduce gastrointestinal side effects.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• The dosage and duration of treatment are determined by your doctor based on your medical condition and response to treatment.
• Do not stop taking this medicine abruptly without consulting your doctor, as it may lead to an increase in blood sugar levels and an increased risk of complications.

Side Effects

• Common Side Effects: Nausea, vomiting, diarrhea, headache, dizziness, frequent urination, mild skin rash, itchy skin, stomach ache or discomfort, loss of appetite, sore throat, nasal congestion (nasopharyngitis), urinary tract infections, and genital fungal infections. Most of these side effects are temporary and usually resolve over time.
• Serious Side Effects: Seek immediate medical attention if you experience symptoms of lactic acidosis (e.g., extreme weakness, severe stomach pain, muscle cramps, difficulty breathing, or low body temperature), severe urinary tract infections, or electrolyte imbalances. Hypoglycemia (low blood sugar) can occur, especially when used with other antidiabetic medicines, alcohol, or if meals are delayed or missed.

Precautions

• Contraindications: Do not take this medicine if you are allergic to dapagliflozin, metformin, or any other component of the tablet. It is also contraindicated in patients with type 1 diabetes mellitus, severe kidney or liver disease, diabetic ketoacidosis, acute or chronic metabolic acidosis, dehydration, severe infection, recent heart attack, heart failure, hypoxemia, or uncontrolled diabetes.
• Alcohol: Avoid consuming alcohol as it may increase the risk of lactic acidosis and low blood sugar levels.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding. Consult your doctor to discuss potential risks and benefits.
• Other Warnings:
  • Caution is advised in elderly patients (aged 65 years or above) due to potential age-related changes in kidney function; regular monitoring is recommended.
  • Not recommended for individuals aged 85 years or older or children and adolescents under 18 years of age.
  • Inform your doctor about any history of heart, kidney, or liver disease; breathing problems; blood disorders; dehydration; low blood pressure; or yeast infection of the genitals.
  • Inform your doctor about all other medicines, supplements, or herbal products you are taking, especially diuretics, carbonic anhydrase inhibitors (e.g., acetazolamide), medicines that reduce metformin clearance (e.g., ranolazine, cimetidine), insulin, or sulfonylureas, as these may interact with Daparyl M.
  • Monitor blood sugar levels regularly as advised by your doctor.
  • Stay well-hydrated by drinking plenty of fluids to help prevent dehydration and urinary tract infections. Practice good genital hygiene to prevent fungal infections.
  • Your ability to drive or operate machinery may be affected if your blood sugar levels are too high or too low.

Storage Store DAPARYL M 5 / 500 MG TABLET in a cool and dry place, away from direct sunlight. The recommended storage temperature is typically between 10ºC to 25ºC or below 30ºC. Keep out of sight and reach of children.

Here are frequently asked questions about DAPARYL M 5/500 MG TABLET:

What is DAPARYL M 5/500 MG TABLET used for?

DAPARYL M 5/500 MG TABLET is primarily used to treat type 2 diabetes mellitus in adults. It helps to control high blood glucose levels, improve glycemic control, and can also reduce the risk of hospitalization for heart failure and the risk of worsening kidney disease in patients with type 2 diabetes who have existing heart or chronic kidney disease.

How does DAPARYL M 5/500 MG TABLET work?

This medicine combines two active ingredients: Dapagliflozin and Metformin. Dapagliflozin works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2), which leads to the removal of excess sugar from the body through urine. Metformin works by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Together, they help to lower blood sugar levels effectively.

What is the usual dosage of DAPARYL M 5/500 MG TABLET?

The usual dose for adults with type 2 diabetes is typically one tablet once a day. It is often recommended to take it with food to help reduce stomach upset, and it should be swallowed whole with water, not crushed or chewed. Your doctor will determine the exact dosage and duration based on your medical condition.

What are the possible side effects of DAPARYL M 5/500 MG TABLET?

Common side effects can include nausea, vomiting, diarrhea, headache, dizziness, increased urination, urinary tract infections, and genital fungal infections. More serious but less common side effects can include lactic acidosis (symptoms like severe tiredness, muscle pain, difficulty breathing, stomach pain), and dehydration. If you experience severe or persistent side effects, contact your doctor.

Is DAPARYL M 5/500 MG TABLET safe during pregnancy or breastfeeding?

DAPARYL M 5/500 MG TABLET is generally not recommended during pregnancy, especially in the second and third trimesters, unless clearly necessary, as there is limited information on its safety. It is also not recommended for use during breastfeeding, as it may pass into breast milk. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can DAPARYL M 5/500 MG TABLET be taken with other medications?

It is important to inform your doctor about all medicines, supplements, or herbal products you are currently taking, as DAPARYL M 5/500 MG TABLET can interact with certain drugs. Interactions may occur with diuretics (water pills), insulin, sulfonylureas (other diabetes medications, which can increase the risk of low blood sugar), and iodinated contrast agents used for X-rays.

What precautions should be taken while taking DAPARYL M 5/500 MG TABLET?

Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of lactic acidosis. Inform your doctor if you have kidney or liver disease, a history of heart problems, frequent urinary tract infections, or conditions that might lead to dehydration. This medicine is not for patients with type 1 diabetes mellitus. Regular monitoring of blood sugar levels is important.

What happens if a dose of DAPARYL M 5/500 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should DAPARYL M 5/500 MG TABLET be stored?

Store DAPARYL M 5/500 MG TABLET in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. The recommended storage temperature is typically below 30°C.