Esoz-l Capsules

ESOZ-L CAPSULES by INTEGRACE ORTHO

ESOZ-L CAPSULES are a prescription medication manufactured by Integrace Ortho (also referred to as Integrace Private Limited or Integrace Health), designed to manage various acid-related gastrointestinal disorders.

Composition

Each capsule typically contains:

• Esomeprazole: 40 mg (a proton pump inhibitor)
• Levosulpiride: 75 mg (a prokinetic agent)

Uses

ESOZ-L CAPSULES are primarily used for the treatment and management of:

• Gastroesophageal Reflux Disease (GERD): Including acid reflux, heartburn, and irritation of the esophagus.
• Acidity and Indigestion: To reduce excessive stomach acid production and related discomfort.
• Peptic Ulcers: Healing ulcers in the stomach and upper intestine.
• Dyspepsia and Gastritis: Management of functional dyspepsia and stomach inflammation.
• Zollinger-Ellison Syndrome.
• Erosive Esophagitis.
• Prevention of gastric ulcers induced by NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).

Dosage and Administration

The typical dosage is one capsule taken orally, once daily. It should be swallowed whole with a glass of water, preferably one hour before a meal, usually in the morning. Do not chew, crush, or break the capsule. The duration of treatment depends on the medical condition and response, as advised by a healthcare professional.

Side Effects

Common side effects may include:

• Headache
• Diarrhea or Constipation
• Nausea and Vomiting
• Abdominal pain and Flatulence
• Dizziness and Sleepiness
• Dry mouth

Less common or serious side effects can include fundic gland polyps, allergic reactions, chest pain, severe diarrhea, and changes in liver enzymes. Long-term use may increase the risk of bone fractures and vitamin B12 deficiency.

Precautions

• Allergies: Do not take if allergic to esomeprazole, levosulpiride, or any other ingredients.
• Medical Conditions: Use with caution in patients with severe liver or kidney impairment, heart disease, blood vessel disease, or a history of Neuroleptic Malignant Syndrome. It is contraindicated in cases of breast cancer, pheochromocytoma, mood disorders, or fits.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding, as it may pass into breast milk. Consult a doctor.
• Alcohol: Avoid alcohol consumption as it can intensify side effects and increase stomach acid production.
• Driving/Operating Machinery: May cause dizziness or drowsiness, so caution is advised when driving or operating heavy machinery.
• Drug Interactions: Inform your doctor about all other medications, supplements, or herbal preparations, especially anti-fungal medicines, anti-HIV medicines (like Nelfinavir), cardiac glycosides (e.g., digoxin), immunosuppressants (e.g., tacrolimus), antiplatelet agents (e.g., clopidogrel), and cancer medications (e.g., methotrexate).
• Long-term Use: Prolonged use should be under medical supervision due to risks like bone fractures, vitamin deficiencies, and changes in gut bacteria.
• Children: Safety and efficacy have not been established in children.

Storage

Store ESOZ-L CAPSULES in a cool, dry place, ideally below 30°C (86°F), away from direct sunlight and moisture. Keep the medicine out of the sight and reach of children.

ESOZ-L CAPSULES by INTEGRACE ORTHO is a combination medication used to treat various gastrointestinal issues. It contains two active ingredients: Esomeprazole (40 mg) and Levosulpiride (75 mg).

Here are some frequently asked questions about Esoz L Capsule:

What is Esoz L Capsule used for?

Esoz L Capsule is primarily used to treat gastroesophageal reflux disease (GERD), which includes symptoms like heartburn, acid reflux, and stomach irritation. It also helps in treating conditions such as dyspepsia, peptic ulcers, gastric ulcers, duodenal ulcers, and erosive esophagitis. It helps reduce stomach acid and alleviate associated symptoms like sour taste in the mouth and difficulty swallowing.

How does Esoz L Capsule work?

The capsule contains two active ingredients:

• Esomeprazole (40 mg): This is a proton pump inhibitor (PPI) that works by irreversibly blocking an enzyme system in the stomach's parietal cells called the proton pump, which is responsible for producing stomach acid. By inhibiting this enzyme, esomeprazole effectively suppresses both basal and stimulated gastric acid secretion.
• Levosulpiride (75 mg): This is a selective dopamine D2 receptor antagonist with prokinetic properties. It increases acetylcholine release, which stimulates stomach and intestinal movement and increases pressure on the inferior esophageal sphincter, preventing the backflow of food and acid into the food pipe.

What is the usual dosage of Esoz L Capsule?

The recommended dose should be taken as directed by your doctor. The dosage may vary depending on your health status and response to the medicine. Generally, it is advised to take one capsule daily, preferably in the morning, at least one hour before a meal, on an empty stomach. The capsule should be swallowed whole with a glass of water without chewing or crushing it.

What are the possible side effects of Esoz L Capsule?

Common side effects may include headache, diarrhea, nausea, abdominal pain, constipation, dry mouth, dizziness, and flatulence (excessive gas). Most side effects are temporary and usually resolve on their own. If any side effects persist or worsen, it's important to consult your doctor.

Is Esoz L Capsule safe during pregnancy or breastfeeding?

Caution is advised regarding the use of Esoz L Capsule during pregnancy. It is generally not recommended unless absolutely necessary and only after a careful evaluation of benefits and risks by a doctor, as animal studies have indicated possible harm to the developing baby. Similarly, caution is advised during breastfeeding as the medicine may pass into breast milk and could adversely affect the baby. It is recommended to consult your doctor before using this medication while breastfeeding.

Can Esoz L Capsule be taken with other medications?

Esoz L Capsule can interact with certain other medications. It may increase the levels of digoxin (a cardiac glycoside), tacrolimus (an immunosuppressant), and methotrexate (a cancer medication). Its effectiveness may be reduced if taken with clopidogrel (an antiplatelet agent). It's crucial to inform your doctor about all other medicines, supplements, or herbal preparations you are taking to avoid potential drug interactions. Antacids should be taken with at least a 2-hour gap.

What precautions should be taken while using Esoz L Capsule?

• Liver and Kidney Conditions: Use with caution if you have severe liver or kidney impairment, and dosage adjustments may be necessary.
• Allergies: Avoid if you are allergic to esomeprazole, levosulpiride, or any other ingredients in the capsule.
• Specific Conditions: It is contraindicated in patients with pheochromocytoma (a type of adrenal gland tumor) and should be used with caution in patients with Parkinson's disease, as it may worsen symptoms. It is also not recommended for those with fits, mood disorders, breast cancer, or certain gastrointestinal issues like hemorrhage or obstruction.
• Alcohol: Avoid alcohol consumption as it can intensify some side effects like dizziness and increase stomach acid production.
• Driving/Operating Machinery: This medicine may cause dizziness, numbness, or involuntary movements, so avoid driving or operating heavy machinery if you experience these effects.
• Long-term use: Prolonged use may increase the risk of bone fractures.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Esoz L Capsule be stored?

Store Esoz L Capsule in a cool, dry place with temperatures not exceeding 30°C. Keep it away from direct sunlight, moisture, and out of the reach of children and pets.