Prebris Mnt Tab

PREBRIS MNT TAB by MANKIND PHARMA LTD.

PREBRIS MNT TAB is a combination medication manufactured by Mankind Pharma Ltd., primarily used to manage neuropathic pain.

• Composition: PREBRIS MNT TAB contains three active ingredients:

  • Pregabalin (75mg)
  • Nortriptyline (10mg)
  • Methylcobalamin (1500mcg)

• Uses: This medicine is prescribed for the treatment of long-lasting (chronic) neuropathic pain, which is nerve pain caused by nerve damage. This includes conditions such as:

  • Diabetic peripheral neuropathy
  • Post-herpetic neuralgia (shingles)
  • Spinal cord injury
  • Fibromyalgia It works by calming damaged or overactive nerves, interfering with pain signals, and aiding in the regeneration of damaged nerve cells. It also helps in reducing associated symptoms like mood changes, sleep problems, and tiredness.

• Dosage and Administration: PREBRIS MNT TAB should be taken exactly as prescribed by your doctor. Swallow the tablet whole with water; do not chew or crush it. It can be taken with or without food, but it is recommended to take it at a fixed time each day to maintain consistent medicine levels. Do not stop taking the medicine suddenly without consulting your doctor, as this may lead to withdrawal symptoms or worsening of symptoms.

• Side Effects:

  • Common Side Effects: Dizziness, sleepiness/drowsiness, blurred vision, dry mouth, weight gain, constipation, swelling of hands or feet (peripheral edema), tiredness, difficulty in urination, uncoordinated body movements, increased heart rate, nausea, and headache.
  • Serious Side Effects (rare): Seek immediate medical attention if you experience hypersensitivity reactions (skin redness, blisters, hives, rash, difficulty breathing, wheezing), thoughts of self-harm, irregular heartbeats, significant changes in body temperature, or hallucinations.

• Precautions:

  • Alcohol: Avoid consuming alcohol with PREBRIS MNT TAB, as it can increase dizziness and sleepiness.
  • Pregnancy & Breastfeeding: Generally not recommended during pregnancy or breastfeeding unless advised by a doctor due to potential risks to the baby.
  • Driving & Machinery: Do not drive or operate heavy machinery if you experience dizziness, drowsiness, or blurred vision.
  • Kidney & Liver Disease: Use with caution in patients with kidney or liver impairment; dose adjustments may be necessary.
  • Allergies: Do not take if you are allergic to any of its ingredients.
  • Children: Safety and effectiveness in children have not been established.
  • Inform your doctor about any existing medical conditions, such as diabetes or a history of seizures, and all other medications you are taking to prevent potential interactions.

• Storage: Store PREBRIS MNT TAB in a cool, dry place, protected from direct sunlight, at a temperature below 30°C. Keep it out of the sight and reach of children.

Here are frequently asked questions about PREBRIS MNT Tablet by MANKIND PHARMA LTD.:

What is PREBRIS MNT Tablet used for?

PREBRIS MNT Tablet is a combination medicine primarily used to manage neuropathic pain, especially diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency. Neuropathic pain is a type of pain caused by damage or injury to nerves. It can also be used for conditions like postherpetic neuralgia (shingles), sciatica, spinal cord injuries, fibromyalgia, and chronic pain syndromes such as lower back pain and migraine prevention.

How does PREBRIS MNT Tablet work?

PREBRIS MNT Tablet combines three active ingredients: Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin, a form of vitamin B, helps in the production of myelin (a protective substance for nerve fibers) and regenerates damaged nerve cells. Nortriptyline is a tricyclic antidepressant that increases the levels of chemical messengers like serotonin and noradrenaline in the brain, which helps to stop the movement of pain signals. Pregabalin is an anticonvulsant that reduces pain by altering the calcium channel activity of nerve cells and interfering with pain messages traveling through the brain and spinal cord.

What is the usual dosage of PREBRIS MNT Tablet?

The dosage and duration of PREBRIS MNT Tablet will be determined by your doctor based on your age, body weight, and medical condition. It should be taken as prescribed, either with or without food, and swallowed whole without crushing or chewing. It is important to take it at the same time each day to maintain consistent medicine levels.

What are the possible side effects of PREBRIS MNT Tablet?

Common side effects include dry mouth, dizziness, sleepiness, blurred vision, weight gain, trouble concentrating, swelling of hands or feet (peripheral edema), constipation, nausea, vomiting, and fatigue. Some serious but rare side effects can include hypersensitivity reactions, thoughts of self-harm, changes in mood or behavior, increased heart rate, or difficulty with urination. If any side effects worsen or you experience severe symptoms, contact your physician immediately.

Is PREBRIS MNT Tablet safe during pregnancy or breastfeeding?

PREBRIS MNT Tablet is generally not recommended for use in pregnant women unless considered clearly necessary by a doctor, as there are limited human studies, and animal studies have shown harmful effects on the developing baby. It is also generally not recommended for use during breastfeeding as it may pass into breast milk and could harm the baby. Consult your doctor if you are pregnant or breastfeeding.

Can PREBRIS MNT Tablet be taken with other medications?

Before taking PREBRIS MNT Tablet, inform your physician about all other medicines, supplements, or herbal products you are currently taking to avoid possible interactions. It can interact with opioid analgesics (e.g., oxycodone, tramadol), medicines for depression and anxiety (e.g., lorazepam, diazepam, MAO inhibitors), medicines for gastroesophageal reflux (e.g., cimetidine, ranitidine), oral contraceptives, cancer chemotherapy medicines, and certain antibiotics. Taking it with alcohol is contraindicated as it may increase dizziness and sleepiness.

What precautions should be taken while using PREBRIS MNT Tablet?

Inform your doctor if you have liver or kidney problems, diabetes, heart problems, thyroid problems, or a history of seizures or angioedema. This medicine may cause dizziness, sleepiness, and blurred vision, so avoid driving or operating heavy machinery until you know how it affects you. Alcohol consumption should be avoided. Do not stop taking the medicine suddenly without consulting your doctor, as this can lead to withdrawal symptoms.

What happens if a dose of PREBRIS MNT Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects.

How should PREBRIS MNT Tablet be stored?

PREBRIS MNT Tablet should be stored in its original packaging at room temperature in a clean and dry place, away from direct sunlight. It should be kept out of the sight and reach of children.